Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights

ILC2 frequency and activity are inhibited by glucocorticoid treatment via STAT pathway in patients with asthma

(2018) Q.N Yu et al.   ALLERGY

Uncontrolled asthmatics have increased FceRI+ and TGF-β-positive MCTC mast cells and collagen VI in the alveolar parenchyma

(2018) C. K. Andersson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Overexpression of Notch ligand Delta-like-1 by dendritic cells enhances their immunoregulatory capacity and exerts antiallergic effects on Th2-mediated allergic asthma in mice

(2018) Chen-Chen Lee et al.   CLINICAL IMMUNOLOGY

Basophil Membrane Expression of Epithelial Cytokine Receptors in Patients with Severe Asthma

(2018) Monica Boita et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Leukotriene E 4 induces airflow obstruction and mast cell activation through the cysteinyl leukotriene type 1 receptor

(2018) Nikolaos Lazarinis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor

(2018) Tzu-Hsuan Wong et al.   Scientific Reports

Controlling Mast Cell Activation and Homeostasis: Work Influenced by Bill Paul That Continues Today

(2018) Heather L. Caslin et al.   Frontiers in Immunology

Innate and adaptive type 2 immunity in lung allergic inflammation

(2017) Masato Kubo   IMMUNOLOGICAL REVIEWS

Innate immunity as the orchestrator of allergic airway inflammation and resolution in asthma

(2017) Despoina Thiriou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers

(2017) Mohamed H. Shamji et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab

(2017) Anna M. Davies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R

(2017) Huiyun Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lipopolysaccharide/TLR4 Stimulates IL-13 Production through a MyD88-BLT2–Linked Cascade in Mast Cells, Potentially Contributing to the Allergic Response

(2017) A-Jin Lee et al.   JOURNAL OF IMMUNOLOGY

KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma

(2017) Katherine N. Cahill et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

(2017) Kenneth Verstraete et al.   Nature Communications

Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells

(2017) Aida Paivandy et al.   Frontiers in Immunology

New and Anticipated Therapies for Severe Asthma

(2017) Stephen P. Peters et al.   Journal of Allergy and Clinical Immunology-In Practice

Role of viral coinfections in asthma development

(2017) Maria Luz Garcia-Garcia et al.   PLoS One

Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices

(2016) Cynthia J Koziol-White et al.   BRITISH JOURNAL OF PHARMACOLOGY

New Developments in Mast Cell Biology

(2016) Greer Arthur et al.   CHEST

Mast cells in asthma - state of the art

(2016) P. Bradding et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Role of Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

(2016) Daniel Elieh-Ali-Komi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

New Insights Into the Relationship Between Chitinase-3-Like-1 and Asthma

(2016) Daniel Elieh Ali Komi et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Airway inflammation in asthma

(2016) Alex KleinJan   CURRENT OPINION IN PULMONARY MEDICINE

Revisiting the role of the mast cell in asthma

(2016) Cecilia Andersson et al.   CURRENT OPINION IN PULMONARY MEDICINE

Mast cells are associated with exacerbations and eosinophilia in children with severe asthma

(2016) Guillaume Lezmi et al.   EUROPEAN RESPIRATORY JOURNAL

Postmortem serum levels of IgE and mast cell tryptase in fatal asthma

(2016) Maria Pia Scarpelli et al.   FORENSIC SCIENCE INTERNATIONAL

IL-37 a New IL-1 Family Member Emerges as a Key Suppressor of Asthma Mediated by Mast Cells

(2016) P. Conti et al.   IMMUNOLOGICAL INVESTIGATIONS

Repeated FcεRI triggering reveals modified mast cell function related to chronic allergic responses in tissue

(2016) Jolien Suurmond et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway smooth muscle enlargement is associated with protease-activated receptor 2/ligand overexpression in patients with difficult-to-control severe asthma

(2016) Michel Aubier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered Expression of IFN-λ2 in Allergic Airway Disorders and Identification of Its Cell Origins

(2016) Qiuli Wang et al.   MEDIATORS OF INFLAMMATION

Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18

(2016) Junling Wang et al.   MEDIATORS OF INFLAMMATION

Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life

(2016) K R Patel et al.   Mucosal Immunology

Molecularly targeted therapies for asthma: Current development, challenges and potential clinical translation

(2016) Ibrahim Sulaiman et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

P2X7 receptors induce degranulation in human mast cells

(2016) Kathryn J. Wareham et al.   Purinergic Signalling

Mast cells and their activation in lung disease

(2016) Harvinder Virk et al.   Translational Research

Emerging concepts: mast cell involvement in allergic diseases

(2016) Brian D. Modena et al.   Translational Research

Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

(2016) Dean D. Metcalfe et al.   World Allergy Organization Journal

Airway Remodelling in Asthma: From Benchside to Clinical Practice

(2016) Céline Bergeron et al.   Canadian Respiratory Journal

The diagnostic criteria for allergic bronchopulmonary aspergillosis in children with poorly controlled asthma need to be re-evaluated

(2015) Meenu Singh et al.   ACTA PAEDIATRICA

Single-cell analysis of mast cell degranulation induced by airway smooth muscle-secreted chemokines

(2015) Benjamin M. Manning et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Alveolar T-helper type-2 immunity in atopic asthma is associated with poor clinical control

(2015) Anders Bergqvist et al.   CLINICAL SCIENCE

T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production

(2015) Jinfang Zhu   CYTOKINE

Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma

(2015) Gang Wang et al.   EUROPEAN RESPIRATORY JOURNAL

Influence of Omalizumab on Allergen-Specific IgE in Patients with Adult Asthma

(2015) Hiroko Mizuma et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Prostaglandin E2 inhibits mast cell–dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor

(2015) Jesper Säfholm et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle β2Adrenoceptors

(2015) Rebecca J. Lewis et al.   JOURNAL OF IMMUNOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response

(2015) Isabel Ramis et al.   PHARMACOLOGICAL RESEARCH

Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment

(2015) Ian P. Hall et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The role of IL-33 and mast cells in allergy and inflammation

(2015) Rohit Saluja et al.   Clinical and Translational Allergy

Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation

(2014) Yasutaka Motomura et al.   IMMUNITY

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

(2014) Luzheng Xue et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma

(2014) E Suzanne Cohen et al.   mAbs

Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma

(2014) Natasha K. Rogers et al.   PLoS One

Protease Activated Receptor-2 Expression and Function in Asthmatic Bronchial Smooth Muscle

(2014) Benoit Allard et al.   PLoS One

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Spleen Tyrosine Kinase Attenuates Allergen-Mediated Airway Constriction

(2013) Lily Y. Moy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The relationship between eosinophilia and airway remodelling in mild asthma

(2013) S. J. Wilson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2on IgE-dependent secretion from human lung mast cells

(2013) L. J. Kay et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Asthma: The importance of dysregulated barrier immunity

(2013) Bart N. Lambrecht et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of periostin, FENO, IL-13, lebrikzumab, other IL-13 antagonist and dual IL-4/IL-13 antagonist in asthma

(2013) Swati Agrawal et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Role of Interleukin-33 in Innate-Type Immune Cells in Allergy

(2013) Susumu Nakae et al.   ALLERGOLOGY INTERNATIONAL

A phase 1, randomized, placebo-controlled, dose-escalation study of an anti-IL-13 monoclonal antibody in healthy subjects and mild asthmatics

(2012) Peter Hodsman et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IL-13–induced airway mucus production is attenuated by MAPK13 inhibition

(2012) Yael G. Alevy et al.   JOURNAL OF CLINICAL INVESTIGATION

Human lung mast cells modulate the functions of airway smooth muscle cells in asthma

(2011) H. Alkhouri et al.   ALLERGY

The Role of Mast Cells in the Structural Alterations of the Airways as a Potential Mechanism in the Pathogenesis of Severe Asthma

(2011) R. J.F. Carter et al.   CURRENT PHARMACEUTICAL DESIGN

Effect of Imatinib on Airway Smooth Muscle Thickening in a Murine Model of Chronic Asthma

(2011) Chin Kook Rhee et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Mast cell–associated alveolar inflammation in patients with atopic uncontrolled asthma

(2011) Cecilia K. Andersson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast cell adhesion to bronchial smooth muscle in asthma specifically depends on CD51 and CD44 variant 6

(2010) P.-O. Girodet et al.   ALLERGY

Role of Transforming Growth Factor–β in Airway Remodeling in Asthma

(2010) Rabih Halwani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

New Pharmacotherapy for Airway Mucus Hypersecretion in Asthma and COPD: Targeting Intracellular Signaling Pathways

(2010) HonYee Lai et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Mast Cells in Allergic Asthma and Beyond

(2010) Sebastian Reuter et al.   YONSEI MEDICAL JOURNAL

Montelukast in the treatment of asthma and beyond

(2009) Zuzana Diamant et al.   Expert Review of Clinical Immunology

Mast Cell-Dependent Contraction of Human Airway Smooth Muscle Cell-Containing Collagen Gels: Influence of Cytokines, Matrix Metalloproteases, and Serine Proteases

(2009) A. Margulis et al.   JOURNAL OF IMMUNOLOGY

Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

(2009) Patrice Dubreuil et al.   PLoS One