Article
Immunology
Chiel van Geffen, Astrid Deissler, Sandra Beer-Hammer, Bernd Nuernberg, Rupert Handgretinger, Harald Renz, Dominik Hartl, Saeed Kolahian
Summary: The study suggests that MDSCs play a role in lung diseases like asthma through the EP4 pathway, showing that EP4-primed MDSCs can dampen airway inflammation by modulating arginase-1 and nitric oxide synthase-2.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jie Su, Pierre Coleman, Angeliki Ntorla, Rhys Anderson, Michael J. Shattock, Joseph R. Burgoyne
Summary: This study demonstrates that the cytosolic DNA sensor cGAS can activate PKGI directly through the generation of cGAMP, showing a link between inflammation and blood pressure regulation.
Review
Neurosciences
Hiroshi Nango, Komugi Tsuruta, Hiroko Miyagishi, Yuri Aono, Tadashi Saigusa, Yasuhiro Kosuge
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by degeneration of motor neurons and inflammation of the spinal cord. Prostaglandin E-2 (PGE(2)) plays a role in the pathogenesis of ALS and its levels are elevated in ALS patients and model mice. Inhibiting the biosynthesis of PGE(2) has shown therapeutic potential in ALS model mice, but its clinical usefulness is yet to be proven. Understanding the role of PGE(2) in neurodegeneration may lead to the development of novel ALS therapies.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Pharmacology & Pharmacy
Amaia Nazabal, Aitziber Mendiguren, Joseba Pineda
Summary: EP3 receptors modulate the activity of locus coeruleus neurons through a G(i/o) protein and GIRK-mediated mechanism.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feifei Wang, Gang Yu, Qing Yang, Xiao Yi, Linglin Fu, Yanbo Wang
Summary: In this study, a homogeneous polysaccharide was isolated from edible red seaweed and used as a biopolymer matrix to form composite films with small biological molecules. The addition of these molecules improved the barrier properties, wettability, mechanical strength, and antimicrobial activity of the films. The film composed of cAMP and the polysaccharide showed the best characteristics and was applied in fish packaging, extending the shelf life.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Cell Biology
Zhilei Wang, Nian Chen, Zhiyong Li, Guang Xu, Xiaoyan Zhan, Jianyuan Tang, Xiaohe Xiao, Zhaofang Bai
Summary: Inflammation is a protective response regulated by the host, with cGAS-STING pathway playing a crucial role in immune defense, viral infections, fatty liver, and cancer metastasis. The potential impact of this pathway in liver diseases has attracted widespread attention, with pharmacological agonists and antagonists offering new therapeutic possibilities. Understanding the mechanisms of cGAS-STING pathway may lead to the development of effective treatments for liver diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Aritra Bhadra, April K. Scruggs, Silas J. Leavesley, Naga Annamdevula, April H. George, Andrea L. Britain, Christopher M. Francis, Jennifer M. Knighten, Thomas C. Rich, Natalie N. Bauer
Summary: Second messenger signaling is essential for cellular processes. Our study demonstrates that cAMP-enriched EVs can induce second messenger signaling pathways, revealing the significance of EVs as a novel intercellular mechanism for cAMP signaling.
CELLULAR SIGNALLING
(2022)
Article
Microbiology
Ruizhen Li, Wenli Liu, Xiangrui Yin, Fangfang Zheng, Zhenyu Wang, Xingchen Wu, Xiaohua Zhang, Qian Du, Yong Huang, Dewen Tong
Summary: This study found that Brucella outer membrane protein Omp25 could suppress the production of IFN-beta and its downstream IFN-stimulated genes induced by various DNA viruses or IFN-stimulatory DNA. Omp25 promoted the degradation of cyclic GMP-AMP synthase (cGAS) via the ubiquitin-proteasome-dependent pathway, leading to the inhibition of IFN-beta induction in various mammalian monocyte/macrophages.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemical Research Methods
Aiguo Xia, Mingjie Qian, Congcong Wang, Yajia Huang, Zhi Liu, Lei Ni, Fan Jin
Summary: Researchers have developed an engineered Pseudomonas aeruginosa strain with light-dependent intracellular cAMP levels by introducing a photoactivated adenylate cyclase gene. Through blue light illumination, the engineered strain showed increased expression of cAMP responsive promoter and twitching activity, making it suitable for applications in controlling bacterial host infection. Additionally, directional twitching motility of the colonies was achieved through localized light illumination, which will aid in studying contact-dependent interactions between microbial species.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Biochemical Research Methods
Guido Domingo, Milena Marsoni, Luca Chiodaroli, Stefania Fortunato, Marcella Bracale, Maria Concetta De Pinto, Chris Gehring, Candida Vannini
Summary: 3',5'-cyclic adenosine monophosphate (cAMP) is recognized as a crucial signaling molecule in plants, and its role in cellular processes such as hormone response and environmental stimuli has been studied. A phosphoproteomic analysis of tobacco BY-2 cells with modulated cAMP levels revealed the significant impact of cAMP on plant kinome, mRNA processing, and cellular programming. The findings suggest the importance of unperturbed cellular cAMP levels for plant cellular homeostasis and signaling.
Article
Immunology
Marwa Monier Mahmoud Refaie, Manar Fouli Gaber Ibrahim, Michael Atef Fawzy, Elshymaa A. Abdel-Hakeem, Eman Shaaban Mahmoud Abd El Rahman, Nagwa M. Zenhom, Sayed Shehata
Summary: The study found that roflumilast (ROF) may have a cardioprotective effect in an induced myocardial injury model. The results showed that ROF improved and normalized the cardiac damage.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Review
Immunology
Heena Khan, Chanchal Tiwari, Amarjot Kaur Grewal, Thakur Gurjeet Singh, Simran Chauhan, Gaber El-Saber Batiha
Summary: Neurodegenerative diseases are caused by genetic defects and involve the degradation of cyclic nucleotides. PDE7 plays a crucial role in these diseases and may serve as a potential therapeutic target in the future.
INFLAMMOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yu Miao, Li Peng, Zhaolin Chen, Ying Hu, Liangsong Tao, Yan Yao, Yincui Wu, Dashuai Yang, Tao Xu
Summary: This article summarizes the function and mechanism of phosphodiesterase 4B (PDE4B) in cancer and highlights the potential clinical applications of PDE4B inhibitors. Research has shown that PDE4B inhibition can effectively increase cell apoptosis and inhibit cell proliferation, transformation, and migration, thereby effectively inhibiting the development of cancer.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Youchao Qi, Linkai Shi, Guozhen Duan, Yonggui Ma, Peifeng Li
Summary: This study investigated the interaction between TCDCA and TGR5, revealing that TCDCA can bind to the TGR5 receptor and activate it, providing a potential therapeutic target for TCDCA research and theoretical evidence for further studies.
Article
Biology
Ved Mehta, Basavraj Khanppnavar, Dina Schuster, Ilayda Kantarci, Irene Vercellino, Angela Kosturanova, Tarun Iype, Sasa Stefanic, Paola Picotti, Volodymyr M. Korkhov
Summary: Mycobacterium tuberculosis adenylyl cyclase Rv1625c/Cya, an ancestor of mammalian membrane ACs, serves as a model system for studying their structure and function. The transmembrane domain of the enzyme plays a crucial role in regulating the catalytic activity by guiding the assembly of the catalytic domain and responding to extracellular ligands.