Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459

Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation

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Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

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The single nucleotide polymorphismCRTh2rs533116 is associated with allergic asthma and increased expression of CRTh2

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A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

(2012) Kelly Wong McGrath et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma

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Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients

(2012) William W. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis

(2012) Roy Pettipher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Reslizumab for Poorly Controlled, Eosinophilic Asthma

(2011) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma

(2011) N. Barnes et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

(2009) Wendy C. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interaction between prostaglandin D2and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells

(2009) L. Xue et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cluster Analysis and Clinical Asthma Phenotypes

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