Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 135, Issue 1, Pages 245-252Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2014.07.031
Keywords
Aspirin-exacerbated respiratory disease; Samter triad; nasal polyps; asthma; prostaglandin D-2; thromboxane; aspirin desensitization; cysteinyl leukotrienes; urinary eicosanoids; eosinophils
Categories
Funding
- National Institutes of Health [AI007306-27, U19 AI095219-01, 5U19AI070412-06, 153556/153044, K23HL111113-02]
Ask authors/readers for more resources
Background: Aspirin desensitization followed by high-dose aspirin therapy is routinely performed for patients with aspirin-exacerbated respiratory disease (AERD). Little is known about the contributions of mediators other than cysteinyl leukotrienes to aspirin reactions and to the therapeutic benefit of high-dose aspirin therapy. Objective: We investigated differences in urinary eicosanoid metabolite levels and blood eosinophil counts in patients with AERD who tolerate and those who fail aspirin desensitization and also in patients with AERD who were successfully treated with high-dose aspirin therapy. Methods: Twenty-nine patients with AERD were stratified into those who tolerated aspirin desensitization (group I) and those who did not (group II). Urine was analyzed for eicosanoid metabolites at baseline, during aspirin reactions, and during high-dose aspirin therapy. Blood was analyzed for cell differentials at baseline and during aspirin therapy. Results: Basal prostaglandin D-2 metabolite (PGD-M; 13.6 +/- 2.7 vs 7.0 +/- 0.8 pmol/mg creatinine [Cr], P <.05) and thromboxane metabolite (TX-M; 1.4 +/- 0.3 vs 0.9 +/- 0.1 pmol/mg Cr, P <.01) levels were higher in group II than in group I. During aspirin reactions, PGD-M levels remained unchanged, whereas TX-M levels (0.7 +/- 0.1 pmol/mg Cr, P = .07) tended to decrease in group I. In contrast, PGD-M levels increased dramatically in group II (61.3 +/- 19.9 pmol/mg Cr, P <. 05), whereas TX-M levels did not change. The decrease in FEV1 inversely correlated with basal urinary levels of both leukotriene E-4 and PGD-M. Blood eosinophil and basophil levels increased and urinary PGD-M levels (2.2 +/- 0.8 pmol/mg Cr, P <.001) decreased on 2 months of high-dose aspirin therapy in group I. Conclusion: Failure to tolerate aspirin desensitization in a subset of patients with AERD is associated with prostaglandin D2 overproduction. The increase in blood eosinophil and basophil counts during high-dose aspirin therapy might reflect the functional consequences of decreased prostaglandin D2
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available