期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms21051851
关键词
prostaglandins; allergy; asthma; allergic rhinitis; AERD; PGD(2); PGE(2)
资金
- National Research Foundation of Korea - Ministry of Science and Technology
- Ministry of Science, ICT & Future Planning [2017R1A2B2003575]
- Korea Health Technology RD Project [HI17C0387]
- Korea Health Industry Development Institute (KHIDI)
- Ministry of Health Welfare
- Korea University grant
- Korea University Medical Center
- Anam Hospital, Seoul, Republic of Korea [O1905011]
- Korea Health Promotion Institute [HI17C0387000019] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2017R1A2B2003575] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD(2), PGI(2), PGE(2), PGF(2), and thromboxane B-2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease.
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