Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase

Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets

(2012) Xiangli Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Prostanoid Receptors

(2011) Takako Hirata et al.   CHEMICAL REVIEWS

A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations

(2011) Lara Bossini-Castillo et al.   HUMAN MOLECULAR GENETICS

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIK2 Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB

(2011) Tsutomu Sasaki et al.   NEURON

A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models

(2010) Q Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cyclic AMP-mediated immune regulation — Overview of mechanisms of action in T cells

(2010) Randi Mosenden et al.   CELLULAR SIGNALLING

The role of cAMP regulation in controlling inflammation

(2010) A. R. MOORE et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Prostaglandin I2-IP Signaling Promotes Th1 Differentiation in a Mouse Model of Contact Hypersensitivity

(2010) S. Nakajima et al.   JOURNAL OF IMMUNOLOGY

Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/ -Arrestin/cAMP Phosphodiesterase 4 Complex

(2010) E. Bjorgo et al.   MOLECULAR AND CELLULAR BIOLOGY

Downregulation of SIK2 expression promotes the melanogenic program in mice

(2010) Nanao Horike et al.   Pigment Cell & Melanoma Research

Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

(2010) Y. Esaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1α and UCP-1 gene expression in brown adipocytes

(2009) Masaaki Muraoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

The anti-inflammatory target A3 adenosine receptor is over-expressed in rheumatoid arthritis, psoriasis and Crohn’s disease

(2009) A. Ochaion et al.   CELLULAR IMMUNOLOGY

Sequential Polarization and Imprinting of Type 1 T Helper Lymphocytes by Interferon-γ and Interleukin-12

(2009) Edda G. Schulz et al.   IMMUNITY

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

(2008) Dmitry V. Ostanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CD4 T cells: fates, functions, and faults

(2008) J. Zhu et al.   BLOOD

Pharmacological PKA Inhibition: All May Not Be What It Seems

(2008) A. J. Murray   Science Signaling