The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases

Diverse Functions of Autophagy in Liver Physiology and Liver Diseases

(2019) Po-Yuan Ke   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

(2019) Prasun Guha et al.   Cell Reports

Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism

(2019) Xiawei Cheng et al.   MOLECULAR CELL

Noncatalytic functions of IPMK are essential for activation of autophagy and liver regeneration

(2019) Prasun Guha et al.   Autophagy

Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK/mTOR pathway

(2019) Congjian Shi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glycochenodeoxycholate promotes hepatocellular carcinoma invasion and migration by AMPK/mTOR dependent autophagy activation

(2019) Lu Gao et al.   CANCER LETTERS

IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K/AKT/mTOR pathway

(2019) Ting-Juan Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

The suppressive effects of Britannin (Bri) on human liver cancer through inducing apoptosis and autophagy via AMPK activation regulated by ROS

(2018) Yong-Qiang Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The pro-apoptosis effect of sinomenine in renal carcinoma via inducing autophagy through inactivating PI3K/AKT/mTOR pathway

(2018) Fei Deng et al.   BIOMEDICINE & PHARMACOTHERAPY

Comprehensive anti-tumor effect of Brusatol through inhibition of cell viability and promotion of apoptosis caused by autophagy via the PI3K/Akt/mTOR pathway in hepatocellular carcinoma

(2018) Ruifan Ye et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

(2018) Jiali Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

mTOR signaling in stem and progenitor cells

(2018) Delong Meng et al.   DEVELOPMENT

SIRT6 protects against hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy related cell death

(2018) Song Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Micheliolide alleviates hepatic steatosis in db/db mice by inhibiting inflammation and promoting autophagy via PPAR-γ-mediated NF-кB and AMPK/mTOR signaling

(2018) Juan Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of mTOR in Glucose and Lipid Metabolism

(2018) Zhuo Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway

(2018) Furong Liu et al.   ONCOLOGY REPORTS

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

(2018) Andrew M. Kidger et al.   PHARMACOLOGY & THERAPEUTICS

Inhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK–mTOR pathway

(2018) Shaoren Zhang et al.   Drug Design Development and Therapy

Inhibition of glycogen synthase kinase 3β protects liver against ischemia/reperfusion injury by activating 5′ adenosine monophosphate-activated protein kinase-mediated autophagy

(2018) Defu Kong et al.   HEPATOLOGY RESEARCH

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux

(2018) Wei Wan et al.   MOLECULAR CELL

Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling

(2017) Simon J. Cook et al.   FEBS Journal

Irbesartan ameliorates hyperlipidemia and liver steatosis in type 2 diabetic db/db mice via stimulating PPAR-γ, AMPK/Akt/mTOR signaling and autophagy

(2017) Juan Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

(2017) Yang Zhao et al.   Molecular Cancer

mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis

(2017) Wei Wan et al.   MOLECULAR CELL

Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway

(2017) Qi Xiao et al.   Molecular Medicine Reports

Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells

(2017) Lihua Song et al.   MOLECULES

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role of Akt in Chronic Liver Disease and Liver Regeneration

(2017) Ansgar Santel et al.   SEMINARS IN LIVER DISEASE

The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy

(2017) Dongwei Xu et al.   Cell Death & Disease

Treatment of nonalcoholic fatty liver disease: role of AMPK

(2016) Brennan K. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMPK regulates autophagy by phosphorylating BECN1 at threonine 388

(2016) Deyi Zhang et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway

(2016) Qin He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways

(2016) Yu Wang et al.   BMC CANCER

FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in Mice

(2016) Tong-Yan Liu et al.   DIABETES

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma

(2016) Shan-Ying Wu   WORLD JOURNAL OF GASTROENTEROLOGY

Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway

(2015) Li Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells

(2015) Xuejiao Zhao et al.   Autophagy

Tri-iodothyronine preconditioning protects against liver ischemia reperfusion injury through the regulation of autophagy by the MEK/ERK/mTORC1 axis

(2015) Jinghui Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential regulation by AMP and ADP of AMPK complexes containing different   subunit isoforms

(2015) F. A. Ross et al.   BIOCHEMICAL JOURNAL

mTOR signaling in cellular and organismal energetics

(2015) Verena Albert et al.   CURRENT OPINION IN CELL BIOLOGY

The Role of Autophagy in Hepatocellular Carcinoma

(2015) Yoo Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Baicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPKα and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells

(2015) Fang Zheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

Autophagy and Liver Ischemia-Reperfusion Injury

(2015) Raffaele Cursio et al.   Biomed Research International

Ras and autophagy in cancer development and therapy.

(2015) Eran Schmukler et al.   Oncotarget

Ras-Related Tumorigenesis Is Suppressed by BNIP3-Mediated Autophagy through Inhibition of Cell Proliferation

(2015) Shan-Ying Wu et al.   NEOPLASIA

Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies

(2014) Hwan-Woo Park et al.   Autophagy

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

(2014) Simon A. Hawley et al.   BIOCHEMICAL JOURNAL

Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition

(2014) Atsushi Umemura et al.   Cell Metabolism

Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels

(2014) Jin-Hwan Kim et al.   EXPERIMENTAL CELL RESEARCH

A Novel MEK-ERK-AMPK Signaling Axis Controls Chemokine Receptor CCR7-dependent Survival in Human Mature Dendritic Cells

(2014) Pilar López-Cotarelo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic effect of natural compounds on the fatty acid-induced autophagy of activated hepatic stellate cells

(2014) Kuan-Wei Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Metabolic-Stress-Induced Rearrangement of the 14-3-3  Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3  Interaction with Phosphorylated Atg9

(2014) V. K. Weerasekara et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update

(2014) Gülsüm Özlem Elpek   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy in Hepatic Fibrosis

(2014) Yang Song et al.   Biomed Research International

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

(2013) Hai-Xin Yuan et al.   Autophagy

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK–mTOR–SREBP signaling pathway

(2013) Hai Yan Quan et al.   BIOCHEMICAL PHARMACOLOGY

The role of autophagy in liver cancer: Molecular mechanisms and potential therapeutic targets

(2013) Jianzhou Cui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

A Central Role for mTOR in Lipid Homeostasis

(2013) Dudley W. Lamming et al.   Cell Metabolism

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

mTOR in aging, metabolism, and cancer

(2013) Marion Cornu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity

(2013) Xin Li et al.   EMBO REPORTS

Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells

(2013) WEN-WEN HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

(2013) Venus Thomanetz et al.   JOURNAL OF CELL BIOLOGY

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Dynamic association of the ULK1 complex with omegasomes during autophagy induction

(2013) E. Karanasios et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell Proliferation

(2013) Che-Hung Shen et al.   MOLECULAR CELL

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Carbon Monoxide Protects against Hepatic Ischemia/Reperfusion Injury via ROS-Dependent Akt Signaling and Inhibition of Glycogen Synthase Kinase 3β

(2013) Hyo Jeong Kim et al.   Oxidative Medicine and Cellular Longevity

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

mTOR Signaling in Autophagy Regulation in the Kidney

(2013) Ken Inoki   SEMINARS IN NEPHROLOGY

Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1

(2013) Borja Hernández-Breijo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

(2013) Han-Ming Shen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2

(2012) Minsheng Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Porcine Circovirus Type 2 Induces Autophagy via the AMPK/ERK/TSC2/mTOR Signaling Pathway in PK-15 Cells

(2012) B. Zhu et al.   JOURNAL OF VIROLOGY

HBx induces HepG-2 cells autophagy through PI3K/Akt–mTOR pathway

(2012) Peng Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12

(2012) Xiaoqing Gan et al.   NATURE CELL BIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting autophagy for the treatment of liver diseases

(2012) Hong-Min Ni et al.   PHARMACOLOGICAL RESEARCH

Evidence of small fast game exploitation in the Middle Paleolithic of Les Canalettes Aveyron, France

(2012) David Cochard et al.   QUATERNARY INTERNATIONAL

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

(2011) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Targeting cathepsin S induces tumor cell autophagy via the EGFR–ERK signaling pathway

(2011) Kuo-Li Chen et al.   CANCER LETTERS

Role of Autophagy in Cancer Prevention

(2011) Hsin-Yi Chen et al.   Cancer Prevention Research

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Signal control through Raf: in sickness and in health

(2011) Jihan K Osborne et al.   CELL RESEARCH

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Adrenergic Regulation of AMP-activated Protein Kinase in Brown Adipose Tissuein Vivo

(2011) Thomas Pulinilkunnil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways

(2011) James A. McCubrey et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by AMP-activated protein kinase

(2011) Eung-Kyun Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and Akt Determine Apoptotic Cell Death following Perturbations of One-Carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia

(2011) J. N. Kuznetsov et al.   MOLECULAR CANCER THERAPEUTICS

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

(2011) Mohamed Elgendy et al.   MOLECULAR CELL

mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR

(2011) Shanshan Duan et al.   MOLECULAR CELL

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

(2011) Daming Gao et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Tuberous Sclerosis Complex-1 Deficiency Attenuates Diet-Induced Hepatic Lipid Accumulation

(2011) Heidi L. Kenerson et al.   PLoS One

AMP-activated protein kinase: also regulated by ADP?

(2011) D. Grahame Hardie et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells

(2010) Mahvash Zakikhani et al.   BREAST CANCER RESEARCH AND TREATMENT

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

(2010) Audrey Carriere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

AMP-Activated Protein Kinase Inhibits IGF-I Signaling and Protein Synthesis in Vascular Smooth Muscle Cells via Stimulation of Insulin Receptor Substrate 1 S794 and Tuberous Sclerosis 2 S1345 Phosphorylation

(2010) Junyu Ning et al.   MOLECULAR ENDOCRINOLOGY

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC

(2009) M. P. Sajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

(2009) Carol A. Mercer et al.   Autophagy

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

(2009) Nao Hosokawa et al.   Autophagy

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting the RAF–MEK–ERK pathway in cancer therapy

(2009) Clara Montagut et al.   CANCER LETTERS

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation

(2009) Diane S. Lidke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation

(2009) Bin Zheng et al.   MOLECULAR CELL

Liver fibrosis

(2008) Karen Wallace et al.   BIOCHEMICAL JOURNAL

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

(2008) Audrey Carrière et al.   CURRENT BIOLOGY

Follicle-Stimulating Hormone Inhibits Adenosine 5′-Monophosphate-Activated Protein Kinase Activation and Promotes Cell Proliferation of Primary Granulosa Cells in Culture through an Akt-Dependent Pathway

(2008) Pradeep P. Kayampilly et al.   ENDOCRINOLOGY

AMPK: a key regulator of energy balance in the single cell and the whole organism

(2008) D G Hardie   INTERNATIONAL JOURNAL OF OBESITY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

CRAF Autophosphorylation of Serine 621 Is Required to Prevent Its Proteasome-Mediated Degradation

(2008) Catherine Noble et al.   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

The PTEN–PI3K pathway: of feedbacks and cross-talks

(2008) A Carracedo et al.   ONCOGENE

PI3K/PTEN signaling in tumorigenesis and angiogenesis

(2007) Bing-Hua Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS