Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations

G-Quadruplexes as An Alternative Recognition Element in Disease-Related Target Sensing

(2019) Jeunice Ida et al.   MOLECULES

Impact of germline CTC 1 alterations on telomere length in acquired bone marrow failure

(2019) Wenyi Shen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Structural and functional impact of non-synonymous SNPs in the CST complex subunit TEN1: structural genomics approach

(2019) Mohd. Amir et al.   BIOSCIENCE REPORTS

Impact of Gln94Glu mutation on the structure and function of protection of telomere 1, a cause of cutaneous familial melanoma

(2019) Mohd. Amir et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Mutation update: Review of TPP1 gene variants associated with neuronal ceroid lipofuscinosis CLN2 disease

(2019) Emily Gardner et al.   HUMAN MUTATION

Investigating architecture and structure-function relationships in cold shock DNA-binding domain family using structural genomics-based approach

(2019) Mohd. Amir et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

POT1-TPP1 differentially regulates telomerase via POT1 His266 and as a function of single-stranded telomere DNA length

(2019) Mengyuan Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of conformational dynamics of Tyr89Cys mutation in protection of telomeres 1 gene associated with familial melanoma

(2019) Mohd. Amir et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Emerging roles of CST in maintaining genome stability and human disease

(2018) Jason A Stewart   Frontiers in Bioscience-Landmark

The role of telomere binding molecules for normal and abnormal hematopoiesis

(2018) Kentaro Hosokawa et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The C-Terminal Extension Unique to the Long Isoform of the Shelterin Component TIN2 Enhances Its Interaction with TRF2 in a Phosphorylation- and Dyskeratosis Congenita Cluster-Dependent Fashion

(2018) Nya D. Nelson et al.   MOLECULAR AND CELLULAR BIOLOGY

Pathogenic CTC1 mutations cause global genome instabilities under replication stress

(2018) Yuan Wang et al.   NUCLEIC ACIDS RESEARCH

CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells

(2018) Xuyang Feng et al.   Nature Communications

Sequence, structure and evolutionary analysis of cold shock domain proteins, a member of OB fold family

(2018) Mohd. Amir et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Binding of a Telomestatin Derivative Changes the Mechanical Anisotropy of a Human Telomeric G-Quadruplex

(2018) Sagun Jonchhe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The structural biology of the shelterin complex

(2018) Yong Chen   BIOLOGICAL CHEMISTRY

Investigation of deleterious effects of nsSNPs in the POT1 gene: a structural genomics‐based approach to understand the mechanism of cancer development

(2018) Mohd. Amir et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma

(2018) Kim Wong et al.   JAMA Dermatology

Inhibition of telomerase using BIBR1532 enhances doxorubicin-induced apoptosis in pre-B acute lymphoblastic leukemia cells

(2017) Davood Bashash et al.   Hematology

Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer

(2017) Marise R. Heerma van Voss et al.   MEDICAL ONCOLOGY

Targeting telomerase and telomeres to enhance ionizing radiation effects in in vitro and in vivo cancer models

(2017) F. Berardinelli et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Telomeres in cancer: tumour suppression and genome instability

(2017) John Maciejowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Telomeres and telomerase in prostate cancer development and therapy

(2017) Mindy Kim Graham et al.   Nature Reviews Urology

Structural and functional analysis of the human POT1-TPP1 telomeric complex

(2017) Cory Rice et al.   Nature Communications

Telomerase antagonist imetelstat increases radiation sensitivity in esophageal squamous cell carcinoma

(2017) Xuping Wu et al.   Oncotarget

New perspectives on telomerase RNA structure and function

(2017) Cherie Musgrove et al.   Wiley Interdisciplinary Reviews-RNA

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis

(2017) Rosa M. Marión et al.   Stem Cell Reports

Shelterin genes, germ line mutations and chronic lymphocytic leukemia

(2017) Irma Slavutsky   Translational Cancer Research

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

(2016) Paula Martínez et al.   AGING CELL

The differential effects of metronomic gemcitabine and antiangiogenic treatment in patient-derived xenografts of pancreatic cancer: treatment effects on metabolism, vascular function, cell proliferation, and tumor growth

(2016) Donald T. Yapp et al.   ANGIOGENESIS

Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia

(2016) H. E. Speedy et al.   BLOOD

Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin

(2016) Jigar N. Bandaria et al.   CELL

Life and cancer without telomerase: ALT and other strategies for making sure ends (don’t) meet

(2016) Manasi S. Apte et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Grafting of gallic acid onto chitosan nano particles enhances antioxidant activities in vitro and protects against ochratoxin A toxicity in catfish ( Clarias gariepinus )

(2016) Mosaad A. Abdel-Wahhab et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Benzophenone-nucleoside derivatives as telomerase inhibitors: Design, synthesis and anticancer evaluation in vitro and in vivo

(2016) Jing Bo Shi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in targeting the telomeric G-quadruplex DNA sequence with small molecules as a strategy for anticancer therapies

(2016) Mohammad K Islam et al.   Future Medicinal Chemistry

A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus

(2016) Hiroyuki Takai et al.   GENES & DEVELOPMENT

The shelterin complex and hematopoiesis

(2016) Morgan Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations inSTN1cause Coats plus syndrome and are associated with genomic and telomere defects

(2016) Amos J. Simon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A molecular biology and phase II study of imetelstat (GRN163L) in children with recurrent or refractory central nervous system malignancies: a pediatric brain tumor consortium study

(2016) Ralph Salloum et al.   JOURNAL OF NEURO-ONCOLOGY

A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions

(2016) Parastoo Maleki et al.   NUCLEIC ACIDS RESEARCH

AZT exerts its antitumoral effect by telomeric and non-telomeric effects in a mammary adenocarcinoma model

(2016) Romina G. Armando et al.   ONCOLOGY REPORTS

Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells

(2016) Andrea Celeghin et al.   Cell Death & Disease

Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner

(2016) Robin E. Frink et al.   Oncotarget

Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells

(2016) Guangtong Zhou et al.   Oncotarget

TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses

(2016) Xiao-Hui Zheng et al.   Scientific Reports

STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function

(2016) Anukana Bhattacharjee et al.   PLoS Genetics

Structure and function of the telomeric CST complex

(2016) Cory Rice et al.   Computational and Structural Biotechnology Journal

Recent developments in brain tumor predisposing syndromes

(2015) Gunnar Johansson et al.   ACTA ONCOLOGICA

Shelterin Proteins and Cancer

(2015) Trupti NV Patel et al.   Asian Pacific Journal of Cancer Prevention

A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells

(2015) Jean-François Spinella et al.   BMC CANCER

Whole exome sequencing in an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 variation

(2015) Manjunath Netravathi et al.   BMC Medical Genetics

Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder

(2015) Galina Glousker et al.   BRITISH JOURNAL OF HAEMATOLOGY

G-quadruplex ligands exhibit differential G-tetrad selectivity

(2015) D. D. Le et al.   CHEMICAL COMMUNICATIONS

The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells

(2015) F. Berardinelli et al.   DNA REPAIR

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

(2015) M. Garcia-Beccaria et al.   EMBO Molecular Medicine

POT1: a genetic link for familial glioma

(2015) Sanjeet Bagcchi   LANCET ONCOLOGY

Molecular basis of telomere dysfunction in human genetic diseases

(2015) Grzegorz Sarek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomere maintenance and the etiology of adult glioma

(2015) Kyle M. Walsh et al.   NEURO-ONCOLOGY

Cerebro-retinal microangiopathy with calcifications and cysts due to recessive mutations in the CTC1 gene

(2015) A. Bisserbe et al.   REVUE NEUROLOGIQUE

A combination of the telomerase inhibitor, BIBR1532, and paclitaxel synergistically inhibit cell proliferation in breast cancer cell lines

(2015) Yi Shi et al.   Targeted Oncology

A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families

(2015) Oriol Calvete et al.   Nature Communications

Molecular basis of telomere dysfunction in human genetic diseases

(2015) Grzegorz Sarek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres

(2015) Amanda K. Frank et al.   PLoS Genetics

Nutritional Energy Stimulates NAD+ Production to Promote Tankyrase-Mediated PARsylation in Insulinoma Cells

(2015) Linlin Zhong et al.   PLoS One

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma

(2015) Ryan T Pitman et al.   Oncotarget

A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer

(2014) A. A. Chiappori et al.   ANNALS OF ONCOLOGY

Bone marrow failure and the telomeropathies

(2014) D. M. Townsley et al.   BLOOD

Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1

(2014) Y. Guo et al.   BLOOD

Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1

(2014) Hande Kocak et al.   GENES & DEVELOPMENT

A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice

(2014) D. Frescas et al.   GENES & DEVELOPMENT

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

(2014) Alec N. Sexton et al.   GENES & DEVELOPMENT

Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection

(2014) David Frescas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma

(2014) Matthew N. Bainbridge et al.   JNCI-Journal of the National Cancer Institute

Nonsense Mutations in the Shelterin Complex Genes ACD and TERF2IP in Familial Melanoma

(2014) Lauren G. Aoude et al.   JNCI-Journal of the National Cancer Institute

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

(2014) Gary Middleton et al.   LANCET ONCOLOGY

TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1

(2014) D. Frescas et al.   MOLECULAR AND CELLULAR BIOLOGY

POT1 loss-of-function variants predispose to familial melanoma

(2014) Carla Daniela Robles-Espinoza et al.   NATURE GENETICS

Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma

(2014) Jianxin Shi et al.   NATURE GENETICS

RHPS4 G-Quadruplex Ligand Induces Anti-Proliferative Effects in Brain Tumor Cells

(2014) Sunil Lagah et al.   PLoS One

Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus

(2013) Peili Gu et al.   AGING CELL

Molecular basis of telomere syndrome caused by CTC1 mutations

(2013) L.-Y. Chen et al.   GENES & DEVELOPMENT

Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita

(2013) Bari J. Ballew et al.   HUMAN GENETICS

Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative

(2013) Wan Jun Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of New Natural DNA G-Quadruplex Binders Selected by a Structure-Based Virtual Screening Approach

(2013) Anna Artese et al.   MOLECULES

G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets

(2013) Joanna Bidzinska et al.   MOLECULES

POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia

(2013) Andrew J Ramsay et al.   NATURE GENETICS

No end in sight for telomerase-targeted cancer drugs

(2013) Sarah C P Williams   NATURE MEDICINE

p300-mediated acetylation of TRF2 is required for maintaining functional telomeres

(2013) Yoon Ra Her et al.   NUCLEIC ACIDS RESEARCH

Alternative lengthening of telomeres is induced by telomerase inhibitors in Barrett’s esophageal cells

(2013) XIUGUANG QIN et al.   ONCOLOGY REPORTS

Structure of the Human Telomeric Stn1-Ten1 Capping Complex

(2013) Christopher Bryan et al.   PLoS One

Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment

(2013) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of telomerase induces alternative lengthening of telomeres during human esophageal carcinogenesis

(2013) Angela Queisser et al.   Cancer Genetics

Interaction of Berberine derivative with protein POT1 affect telomere function in cancer cells

(2012) Nannan Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

Posttranslational control of telomere maintenance and the telomere damage response

(2012) Marieke H. Peuscher et al.   CELL CYCLE

Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene,c-Myb

(2012) Takeshi Miyazaki et al.   CLINICAL CANCER RESEARCH

A three-state model of telomere control over human proliferative boundaries

(2012) Anthony J Cesare et al.   CURRENT OPINION IN CELL BIOLOGY

Human CST promotes telomere duplex replication and general replication restart after fork stalling

(2012) Jason A Stewart et al.   EMBO JOURNAL

CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion

(2012) Peili Gu et al.   EMBO JOURNAL

Gemcitabine causes telomere attrition by stabilizing TRF2

(2012) Chih-Hao Su et al.   EUROPEAN JOURNAL OF CANCER

Mutations in the telomere capping complex in bone marrow failure and related syndromes

(2012) A. J. Walne et al.   HAEMATOLOGICA

Specificity Requirements for Human Telomere Protein Interaction with Telomerase Holoenzyme

(2012) Alec N. Sexton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance

(2012) John R. Walker et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control

(2012) Liuh-Yow Chen et al.   MOLECULAR CELL

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

The human CST complex is a terminator of telomerase activity

(2012) Liuh-Yow Chen et al.   NATURE

Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

(2012) Beverley H Anderson et al.   NATURE GENETICS

An emerging role for the conserved telomere component 1 (CTC1) in human genetic disease

(2012) Mary Armanios   PEDIATRIC BLOOD & CANCER

CTC1 Mutations in a patient with dyskeratosis congenita

(2012) Rachel B. Keller et al.   PEDIATRIC BLOOD & CANCER

Pleiotropic Roles of Cold Shock Domain Proteins in Plants

(2012) Kentaro Sasaki et al.   Frontiers in Plant Science

AZT as a telomerase inhibitor

(2012) Daniel E. Gomez et al.   Frontiers in Oncology

Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA

(2011) Yan Xu   CHEMICAL SOCIETY REVIEWS

Three novel truncating TINF2 mutations causing severe dyskeratosis congenita in early childhood

(2011) GS Sasa et al.   CLINICAL GENETICS

A role for heterochromatin protein 1  at human telomeres

(2011) S. Canudas et al.   GENES & DEVELOPMENT

Targeted inhibition of telomerase activity combined with chemotherapy demonstrates synergy in eliminating ovarian cancer spheroid-forming cells

(2011) Erhong Meng et al.   GYNECOLOGIC ONCOLOGY

Heterogeneous telomere defects in patients with severe forms of dyskeratosis congenita

(2011) Fabien Touzot et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TIN2 Protein Dyskeratosis Congenita Missense Mutants Are Defective in Association with Telomerase

(2011) Dong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting telomerase-expressing cancer cells

(2011) Michel M. Ouellette et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Multiple POT1–TPP1 Proteins Coat and Compact Long Telomeric Single-Stranded DNA

(2011) Derek J. Taylor et al.   JOURNAL OF MOLECULAR BIOLOGY

Telomere Protection by TPP1/POT1 Requires Tethering to TIN2

(2011) Kaori K. Takai et al.   MOLECULAR CELL

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase

(2011) Q. Wang et al.   NUCLEIC ACIDS RESEARCH

DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe

(2011) Jayakrishnan Nandakumar et al.   NUCLEIC ACIDS RESEARCH

T-Oligos Inhibit Growth and Induce Apoptosis in Human Ovarian Cancer Cells

(2011) Sibaji Sarkar et al.   OLIGONUCLEOTIDES

Role of shelterin in cancer and aging

(2010) Paula Martínez et al.   AGING CELL

Molecular Cloning of the Human Platelet-Derived Growth Factor Receptor β (PDGFR-β) Promoter and Drug Targeting of the G-Quadruplex-Forming Region To Repress PDGFR-β Expression

(2010) Yong Qin et al.   BIOCHEMISTRY

The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

(2010) Rekha Rai et al.   EMBO JOURNAL

POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation

(2010) Chrysa M Latrick et al.   EMBO JOURNAL

Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer

(2010) Hua Hu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Rational Design of Acridine-Based Ligands with Selectivity for Human Telomeric Quadruplexes

(2010) Silvia Sparapani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo

(2010) E. Abreu et al.   MOLECULAR AND CELLULAR BIOLOGY

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells

(2009) Darren E. Casteel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes

(2009) Yulia V. Surovtseva et al.   MOLECULAR CELL

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telomere Diseases

(2009) Rodrigo T. Calado et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-Oligo Induces Apoptosis in Advanced Prostate Cancer Cells

(2009) Munirathinam Gnanasekar et al.   OLIGONUCLEOTIDES

TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita

(2008) Sharon A. Savage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions

(2008) C. M. Raynaud et al.   ANNALS OF ONCOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands

(2008) Francisco Cuenca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita

(2008) F. D. Goldman et al.   BLOOD

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

(2008) A. J. Walne et al.   BLOOD

Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2

(2008) A. Konishi et al.   GENES & DEVELOPMENT

Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: Mechanism and therapeutic potential

(2008) Harold O. Longe et al.   INTERNATIONAL JOURNAL OF CANCER

Tethering Telomeric Double- and Single-stranded DNA-binding Proteins Inhibits Telomere Elongation

(2008) Katherine T. Etheridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of DNA Quadruplex Recognition by an Acridine Drug

(2008) Nancy H. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional Dissection of Human and Mouse POT1 Proteins

(2008) W. Palm et al.   MOLECULAR AND CELLULAR BIOLOGY

Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model

(2008) B. Laquente et al.   MOLECULAR CANCER THERAPEUTICS

A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins

(2008) Y. Chen et al.   SCIENCE