Recent advances in targeting the telomeric G-quadruplex DNA sequence with small molecules as a strategy for anticancer therapies

Interaction of human telomeric G-quadruplex DNA with thymoquinone: A possible mechanism for thymoquinone anticancer effect

(2015) Alaa A. Salem et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Macrocyclic naphthalene diimides as G-quadruplex binders

(2015) Chiara Marchetti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antiproliferative activity of 2,7-diamino l0-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as potent telomeric G-quadruplex DNA ligands

(2015) Chunmei Gao et al.   BIOORGANIC CHEMISTRY

Indolo[3,2-c]quinoline G-Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G-Quadruplex

(2015) João Lavrado et al.   ChemMedChem

Recognition of human telomeric G-quadruplex DNA by berberine analogs: effect of substitution at the 9 and 13 positions of the isoquinoline moiety

(2015) Debipreeta Bhowmik et al.   JOURNAL OF MOLECULAR RECOGNITION

Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes

(2015) Pavel Kopel et al.   MOLECULES

A Selective G-Quadruplex DNA-Stabilizing Ligand Based on a Cyclic Naphthalene Diimide Derivative

(2015) Md. Islam et al.   MOLECULES

Loop flexibility in human telomeric quadruplex small-molecule complexes

(2015) Gavin W. Collie et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

New dimeric carbazole–benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer

(2015) Basudeb Maji et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Toward the Design of a Catalytic Metallodrug: Selective Cleavage of G-Quadruplex Telomeric DNA by an Anticancer Copper-Acridine-ATCUN Complex

(2014) Zhen Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Finding a human telomere DNA–RNA hybrid G-quadruplex formed by human telomeric 6-mer RNA and 16-mer DNA using click chemistry: A protective structure for telomere end

(2014) Yan Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel trisubstituted acridines as human telomeric quadruplex binding ligands

(2014) Jan Ungvarsky et al.   BIOORGANIC CHEMISTRY

Telomere Maintenance Mechanisms in Cancer: Clinical Implications

(2014) Roger Reddel   CURRENT PHARMACEUTICAL DESIGN

Design and Synthesis of New Benzimidazole–Carbazole Conjugates for the Stabilization of Human Telomeric DNA, Telomerase Inhibition, and Their Selective Action on Cancer Cells

(2014) Basudeb Maji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand

(2014) Marco Di Antonio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines

(2013) Věra Králová et al.   ANTI-CANCER DRUGS

Development of Therapeutic Combinations Targeting Major Cancer Signaling Pathways

(2013) Timothy A. Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Synthesis, structure, anticancer, and antioxidant activity of para-xylyl linked bis-benzimidazolium salts and respective dinuclear Ag(I) N-heterocyclic carbene complexes (Part-II)

(2013) Rosenani A. Haque et al.   MEDICINAL CHEMISTRY RESEARCH

Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries

(2012) Khondaker M. Rahman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties

(2012) Khondaker M. Rahman et al.   CHEMICAL COMMUNICATIONS

Tetrasubstituted Phenanthrolines as Highly Potent, Water-Soluble, and Selective G-Quadruplex Ligands

(2012) Anders Foller Larsen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oligonucleotide Models of Telomeric DNA and RNA Form a Hybrid G-quadruplex Structure as a Potential Component of Telomeres

(2012) Yan Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of Gemini Bisbenzimidazole Drugs with Human Telomeric G-Quadruplex Dimers: Effect of the Spacer in the Design of Potent Telomerase Inhibitors

(2012) Ananya Paul et al.   PLoS One

Conformational studies and solvent-accessible surface area analysis of known selective DNA G-Quadruplex binders

(2011) Stefano Alcaro et al.   BIOCHIMIE

Selective G-quadruplex DNA Stabilizing Agents Based on Bisquinolinium and Bispyridinium Derivatives of 1,8-Naphthyridine

(2011) V. Dhamodharan et al.   JOURNAL OF ORGANIC CHEMISTRY

Telomere dysfunction and chromosome instability

(2011) John P. Murnane   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

(2010) Ho-Man Lee et al.   CHEMICAL COMMUNICATIONS

Rational Design of Acridine-Based Ligands with Selectivity for Human Telomeric Quadruplexes

(2010) Silvia Sparapani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Evaluation of a Novel Class of G-Quadruplex-Stabilizing Small Molecules Based on the 1,3-Phenylene-Bis(piperazinyl benzimidazole) System

(2009) Akash K. Jain et al.   BIOCHEMISTRY

Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves

(2009) Qian Li et al.   BIOCHIMIE

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers

(2009) Jamal El Bakali et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands

(2009) Yan Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biaryl polyamides as a new class of DNA quadruplex-binding ligands

(2009) Khondaker M. Rahman et al.   CHEMICAL COMMUNICATIONS

The structures of quadruplex nucleic acids and their drug complexes

(2009) Stephen Neidle   CURRENT OPINION IN STRUCTURAL BIOLOGY

Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands

(2009) Marie Laronze-Cochard et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isaindigotone Derivatives: A New Class of Highly Selective Ligands for Telomeric G-Quadruplex DNA

(2009) Jia-Heng Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Metal-Mediated Conformational Switch Controls G-Quadruplex Binding Affinity

(2008) David Monchaud et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

G-quadruplex recognition by bis-indole carboxamides

(2008) Jyotirmayee Dash et al.   CHEMICAL COMMUNICATIONS

Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition

(2008) Zoë A. E. Waller et al.   CHEMICAL COMMUNICATIONS

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition

(2008) Sebastian Müller et al.   CHEMICAL COMMUNICATIONS

Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes

(2008) Julian Leon Huppert   CHEMICAL SOCIETY REVIEWS

Discovery of a Drug-Like G-Quadruplex Binding Ligand by High-Throughput Docking

(2008) Dik-Lung Ma et al.   ChemMedChem

Rational Design of Substituted Diarylureas: A Scaffold for Binding to G-Quadruplex Motifs

(2008) William C. Drewe et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-NPositive Charge on Quadruplex Binding Affinity and Cell Proliferation

(2008) Yu-Jing Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topology Conservation and Loop Flexibility in Quadruplex–Drug Recognition: Crystal Structures of Inter- and Intramolecular Telomeric DNA Quadruplex–Drug Complexes

(2008) Gary N. Parkinson et al.   JOURNAL OF MOLECULAR BIOLOGY

Energetics of the Human Tel-22 Quadruplex−Telomestatin Interaction: A Molecular Dynamics Study

(2008) Saurabh Agrawal et al.   JOURNAL OF PHYSICAL CHEMISTRY B

G-quadruplexes: the beginning and end of UTRs

(2008) Julian Leon Huppert et al.   NUCLEIC ACIDS RESEARCH

Telomeres and Aging

(2008) Geraldine Aubert et al.   PHYSIOLOGICAL REVIEWS

Telomerase and its potential for therapeutic intervention

(2007) P Phatak et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery of alternative DNA structures: a heroic decade (1979-1989)

(2007) Sergei et al.   Frontiers in Bioscience-Landmark