Life and cancer without telomerase: ALT and other strategies for making sure ends (don’t) meet

Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients

(2016) Yuan Yuan et al.   CANCER CELL

SMARCAL1 Resolves Replication Stress at ALT Telomeres

(2016) Kelli E. Cox et al.   Cell Reports

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells

(2015) Mahesh Ramamoorthy et al.   CANCER CELL

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding

(2015) Grzegorz Sarek et al.   MOLECULAR CELL

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomeric repeat silencing in germ cells is essential for early development inDrosophila

(2015) Valeriya Morgunova et al.   NUCLEIC ACIDS RESEARCH

TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization

(2015) Alessandra Galati et al.   NUCLEIC ACIDS RESEARCH

SMARCAL1 maintains telomere integrity during DNA replication

(2015) Lisa A. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

Telomere functions grounding on TERRA firma

(2015) Claus M. Azzalin et al.   TRENDS IN CELL BIOLOGY

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATRX represses alternative lengthening of telomeres

(2015) Christine E. Napier et al.   Oncotarget

The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres

(2015) Giovanni Cenci et al.   PLoS Genetics

Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells

(2015) Kyu-Tae Kim et al.   GENOME BIOLOGY

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity

(2015) Emilio Cusanelli et al.   Frontiers in Genetics

ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses

(2014) R. Josse et al.   CANCER RESEARCH

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

Telomerase-Dependent and Independent Telomere Maintenance and its Clinical Implications in Medullary Thyroid Carcinoma

(2014) Na Wang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

(2014) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin

(2014) Harikleia Episkopou et al.   NUCLEIC ACIDS RESEARCH

Functional characterization of the TERRA transcriptome at damaged telomeres

(2014) Antonio Porro et al.   Nature Communications

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

(2014) Antonio Porro et al.   Cell Reports

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening

(2013) Verena Pfeiffer et al.   EMBO JOURNAL

A new genome-driven integrated classification of breast cancer and its implications

(2013) Sarah-Jane Dawson et al.   EMBO JOURNAL

Alternative lengthening of telomeres in normal mammalian somatic cells

(2013) A. A. Neumann et al.   GENES & DEVELOPMENT

SA1 binds directly to DNA through its unique AT-hook to promote sister chromatid cohesion at telomeres

(2013) K. K. Bisht et al.   JOURNAL OF CELL SCIENCE

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span

(2013) L. Ashley Watson et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

(2013) Kevin M. Foote et al.   JOURNAL OF MEDICINAL CHEMISTRY

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres

(2013) Emilio Cusanelli et al.   MOLECULAR CELL

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

(2013) Bettina Balk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells

(2013) Hugo Almeida et al.   NUCLEIC ACIDS RESEARCH

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes

(2013) Michael Lee et al.   NUCLEIC ACIDS RESEARCH

Spatial Dynamics of Chromosome Translocations in Living Cells

(2013) V. Roukos et al.   SCIENCE

The chromatin remodeller ATRX: a repeat offender in human disease

(2013) David Clynes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Histone marks: repairing DNA breaks within the context of chromatin

(2012) Kyle M. Miller et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Novel anticancer therapeutics targeting telomerase

(2012) Maria Ruden et al.   CANCER TREATMENT REVIEWS

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

ATRX-mediated chromatin association of histone variant macroH2A1 regulates  -globin expression

(2012) K. Ratnakumar et al.   GENES & DEVELOPMENT

Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End

(2012) R. J. Wellinger et al.   GENETICS

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells

(2012) Dimitri Conomos et al.   JOURNAL OF CELL BIOLOGY

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

DAXX envelops a histone H3.3–H4 dimer for H3.3-specific recognition

(2012) Simon J. Elsässer et al.   NATURE

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery

(2012) Vincent Dion et al.   NATURE CELL BIOLOGY

TRF2 Controls Telomeric Nucleosome Organization in a Cell Cycle Phase-Dependent Manner

(2012) Alessandra Galati et al.   PLoS One

The Chromosomal Proteins JIL-1 and Z4/Putzig Regulate the Telomeric Chromatin in Drosophila melanogaster

(2012) Rute Silva-Sousa et al.   PLoS Genetics

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication

(2011) Raghav Chawla et al.   EMBO JOURNAL

Non-coding telomeric and subtelomeric transcripts are differentially regulated by telomeric and heterochromatin assembly factors in fission yeast

(2011) Jessica Greenwood et al.   NUCLEIC ACIDS RESEARCH

The telomeric transcriptome of Schizosaccharomyces pombe

(2011) Amadou Bah et al.   NUCLEIC ACIDS RESEARCH

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

Terminin: A protein complex that mediates epigenetic maintenance ofDrosophilatelomeres

(2011) Grazia D. Raffa et al.   Nucleus

Pilocytic Astrocytomas Have Telomere-Associated Promyelocytic Leukemia Bodies without Alternatively Lengthened Telomeres

(2010) Tania Slatter et al.   AMERICAN JOURNAL OF PATHOLOGY

Telomeric Strategies: Means to an End

(2010) Devanshi Jain et al.   Annual Review of Genetics

The interface between transcription and mRNP export: From THO to THSC/TREX-2

(2010) Ana G. Rondón et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

ATRX: Put Me on Repeat

(2010) Iestyn Whitehouse et al.   CELL

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

(2010) Martin J. Law et al.   CELL

Role of TRF2 in the assembly of telomeric chromatin

(2010) Roberta Benetti et al.   CELL CYCLE

HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner

(2010) Guanjun Gao et al.   EMBO JOURNAL

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

(2010) Jeremy D. Henson et al.   FEBS LETTERS

Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex

(2010) G. D. Raffa et al.   GENES & DEVELOPMENT

HAATI survivors replace canonical telomeres with blocks of generic heterochromatin

(2010) Devanshi Jain et al.   NATURE

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

The human telomeric protein hTRF1 induces telomere-specific nucleosome mobility

(2010) Sabrina Pisano et al.   NUCLEIC ACIDS RESEARCH

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Functions for the Drosophila piRNA Pathway in Genome Maintenance and Telomere Protection

(2010) Jaspreet S. Khurana et al.   PLoS Genetics

Similar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas suggest a common pathway to tumorigenesis

(2009) Erik F Hensen et al.   BMC Medical Genomics

Purification of Proteins Associated with Specific Genomic Loci

(2009) Jérôme Déjardin et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Regulation of telomere length in Drosophila

(2009) R. Capkova Frydrychova et al.   CYTOGENETIC AND GENOME RESEARCH

Telomere capping and cellular checkpoints: clues from fruit flies

(2009) L. Ciapponi et al.   CYTOGENETIC AND GENOME RESEARCH

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart

(2009) A. Ciccia et al.   GENES & DEVELOPMENT

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks

(2009) C. E. Bansbach et al.   GENES & DEVELOPMENT

Healing of Euchromatic Chromosome Breaks by Efficient de novo Telomere Addition in Drosophila melanogaster

(2009) S. W. A. Titen et al.   GENETICS

Telomerase-associated Protein 1, HSP90, and Topoisomerase IIα Associate Directly with the BLM Helicase in Immortalized Cells Using ALT and Modulate Its Helicase Activity Using Telomeric DNA Substrates

(2009) Saumitri Bhattacharyya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression

(2009) Andrea Proctor Subhawong et al.   MODERN PATHOLOGY

Sumoylation of RecQ Helicase Controls the Fate of Dysfunctional Telomeres

(2009) Ofer Rog et al.   MOLECULAR CELL

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT

(2009) K Lafferty-Whyte et al.   ONCOGENE

The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection

(2009) G. D. Raffa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination

(2008) Louise J. Barber et al.   CELL

Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks

(2008) Yikang S. Rong   CHROMOSOMA

Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma

(2008) R. Villa et al.   CLINICAL CANCER RESEARCH

Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres

(2008) A. Muntoni et al.   HUMAN MOLECULAR GENETICS

Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies

(2008) Jennie N. Jeyapalan et al.   INTERNATIONAL JOURNAL OF CANCER

Chromosome Fusions following Telomere Loss Are Mediated by Single-Strand Annealing

(2008) Xiaorong Wang et al.   MOLECULAR CELL

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

Alternative lengthening of telomeres (ALT) and chromatin: Is there a connection?

(2007) Thalia Nittis et al.   BIOCHIMIE