The structural biology of the shelterin complex

Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction

(2018) Xia Chen et al.   ACS Medicinal Chemistry Letters

Structural Basis for Shelterin Bridge Assembly

(2017) Jin-Kwang Kim et al.   MOLECULAR CELL

Dissecting the telomere–inner nuclear membrane interface formed in meiosis

(2017) Devon F Pendlebury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and functional analysis of the human POT1-TPP1 telomeric complex

(2017) Cory Rice et al.   Nature Communications

Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer

(2017) Cong Chen et al.   Nature Communications

Dissecting the telomere–inner nuclear membrane interface formed in meiosis

(2017) Devon F Pendlebury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The multifunctional transcription factor Rap1 a regulator of yeast physiology

(2016) Raghuvir Singh Tomar   Frontiers in Bioscience-Landmark

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

(2016) Delphine Benarroch-Popivker et al.   MOLECULAR CELL

A higher-order entity formed by the flexible assembly of RAP1 with TRF2

(2016) Guillaume Gaullier et al.   NUCLEIC ACIDS RESEARCH

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions

(2016) Rekha Rai et al.   Nature Communications

Structure and function of the telomeric CST complex

(2016) Cory Rice et al.   Computational and Structural Biotechnology Journal

Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2

(2015) Wei Deng et al.   CELL RESEARCH

Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein–Protein Interaction in the Shelterin Complex

(2015) Xu Ran et al.   JOURNAL OF MEDICINAL CHEMISTRY

Replicating through telomeres: a means to an end

(2015) Paula Martínez et al.   TRENDS IN BIOCHEMICAL SCIENCES

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

(2014) Michal Zimmermann et al.   GENES & DEVELOPMENT

Shading the TRF2 Recruiting Function: A New Horizon in Drug Development

(2014) Salvatore Di Maro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1

(2014) D. Frescas et al.   MOLECULAR AND CELLULAR BIOLOGY

Rif1 and Rif2 Shape Telomere Function and Architecture through Multivalent Rap1 Interactions

(2013) Tianlai Shi et al.   CELL

Finding the end: recruitment of telomerase to telomeres

(2013) Jayakrishnan Nandakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

(2012) Peng Wu et al.   CELL

The human CST complex is a terminator of telomerase activity

(2012) Liuh-Yow Chen et al.   NATURE

Telomerase and Telomere-Associated Proteins: Structural Insights into Mechanism and Evolution

(2012) Karen A. Lewis et al.   STRUCTURE

Nonspecific Recognition Is Achieved in Pot1pC through the Use of Multiple Binding Modes

(2012) Thayne H. Dickey et al.   STRUCTURE

BRCT domains

(2011) Charles Chung Yun Leung et al.   CELL CYCLE

Multiple POT1–TPP1 Proteins Coat and Compact Long Telomeric Single-Stranded DNA

(2011) Derek J. Taylor et al.   JOURNAL OF MOLECULAR BIOLOGY

Telomere Protection by TPP1/POT1 Requires Tethering to TIN2

(2011) Kaori K. Takai et al.   MOLECULAR CELL

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms

(2011) Yong Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solution structure of Rap1 BRCT domain from Saccharomyces cerevisiae reveals a novel fold

(2010) Wen Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Taking apart Rap1

(2010) Shaheen Kabir et al.   CELL CYCLE

Structural Basis of Selective Ubiquitination of TRF1 by SCFFbx4

(2010) Zhixiong Zeng et al.   DEVELOPMENTAL CELL

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

Nonadditivity in the Recognition of Single-Stranded DNA by theSchizosaccharomyces pombeProtection of Telomeres 1 DNA-Binding Domain, Pot1-DBD

(2009) Johnny E. Croy et al.   BIOCHEMISTRY

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres

(2009) J. Sun et al.   GENES & DEVELOPMENT

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

(2009) Yasuyuki Miyake et al.   MOLECULAR CELL

How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA

(2009) J. Nandakumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain

(2009) A. D. Gelinas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller

(2008) K. Tomita et al.   GENES & DEVELOPMENT

A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins

(2008) Y. Chen et al.   SCIENCE

Fission Yeast Pot1-Tpp1 Protects Telomeres and Regulates Telomere Length

(2008) T. Miyoshi et al.   SCIENCE