STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function

Mutations inSTN1cause Coats plus syndrome and are associated with genomic and telomere defects

(2016) Amos J. Simon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress

(2016) Megan Chastain et al.   Cell Reports

RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends

(2015) J. Audry et al.   EMBO JOURNAL

The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex

(2015) Bingbing Wan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA

(2015) Norie Sugitani et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex

(2015) Bingbing Wan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

Human CST abundance determines recovery from diverse forms of DNA damage and replication stress

(2014) Feng Wang et al.   CELL CYCLE

The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening

(2014) Karin R. McDonald et al.   DNA REPAIR

Metabolism of DNA secondary structures at the eukaryotic replication fork

(2014) Ana María León-Ortiz et al.   DNA REPAIR

Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association

(2014) M. Garg et al.   EMBO REPORTS

Diffusion of Human Replication Protein A along Single-Stranded DNA

(2014) Binh Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Elucidation of the DNA End-Replication Problem in Saccharomyces cerevisiae

(2014) Julien Soudet et al.   MOLECULAR CELL

Protein dynamics during presynaptic-complex assembly on individual single-stranded DNA molecules

(2014) Bryan Gibb et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

(2014) Sarah K Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1Tpp1 to modulate shelterin-Stn1 interaction in fission yeast

(2014) K. Miyagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch

(2014) Neal F. Lue et al.   Nature Communications

POT1a and Components of CST Engage Telomerase and Regulate Its Activity in Arabidopsis

(2014) Kyle B. Renfrew et al.   PLoS Genetics

Role of STN1 and DNA Polymerase α in Telomere Stability and Genome-Wide Replication in Arabidopsis

(2014) Elisa Derboven et al.   PLoS Genetics

Molecular basis of telomere syndrome caused by CTC1 mutations

(2013) L.-Y. Chen et al.   GENES & DEVELOPMENT

Human TEN1 Maintains Telomere Integrity and Functions in Genome-wide Replication Restart

(2013) Christopher Kasbek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk1 Regulates the Temporal Recruitment of Telomerase and Cdc13-Stn1-Ten1 Complex for Telomere Replication

(2013) C.-C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

The tenacious recognition of yeast telomere sequence by Cdc13 is fully exerted by a single OB-fold domain

(2013) Karen A. Lewis et al.   NUCLEIC ACIDS RESEARCH

Structure of the Human Telomeric Stn1-Ten1 Capping Complex

(2013) Christopher Bryan et al.   PLoS One

The Telomere Capping Complex CST Has an Unusual Stoichiometry, Makes Multipartite Interaction with G-Tails, and Unfolds Higher-Order G-Tail Structures

(2013) Neal F. Lue et al.   PLoS Genetics

CST for the grand finale of telomere replication

(2013) Liuh-Yow Chen et al.   Nucleus

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in

(2012) Chenhui Huang et al.   CELL RESEARCH

Human CST promotes telomere duplex replication and general replication restart after fork stalling

(2012) Jason A Stewart et al.   EMBO JOURNAL

Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening

(2012) T. T. Chow et al.   GENES & DEVELOPMENT

Structure and conformational change of a replication protein A heterotrimer bound to ssDNA

(2012) J. Fan et al.   GENES & DEVELOPMENT

Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End

(2012) R. J. Wellinger et al.   GENETICS

Mutations in the telomere capping complex in bone marrow failure and related syndromes

(2012) A. J. Walne et al.   HAEMATOLOGICA

The human CST complex is a terminator of telomerase activity

(2012) Liuh-Yow Chen et al.   NATURE

An emerging role for the conserved telomere component 1 (CTC1) in human genetic disease

(2012) Mary Armanios   PEDIATRIC BLOOD & CANCER

Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-In

(2012) Feng Wang et al.   Cell Reports

Xenopus laevisCtc1-Stn1-Ten1 (xCST) Protein Complex Is Involved in Priming DNA Synthesis on Single-stranded DNA Template inXenopusEgg Extract

(2011) Hidenori Nakaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repair-specific Functions of Replication Protein A

(2011) Cathy S. Hass et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maintaining the end: Roles of telomere proteins in end-protection, telomere replication and length regulation

(2011) Jason A. Stewart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Pre-calculated protein structure alignments at the RCSB PDB website: Fig. 1.

(2010) Andreas Prlić et al.   BIOINFORMATICS

Evolution of CST function in telomere maintenance

(2010) Carolyn Price et al.   CELL CYCLE

Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α

(2010) Jia Sun et al.   CELL RESEARCH

Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection

(2010) Xueyu Dai et al.   EMBO JOURNAL

Telomeres: Structures in need of unwinding

(2010) Katrin Paeschke et al.   FEBS LETTERS

CST Meets Shelterin to Keep Telomeres in Check

(2010) Marie-Josèphe Giraud-Panis et al.   MOLECULAR CELL

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Telomere Extension Occurs at Most Chromosome Ends and Is Uncoupled from Fill-In in Human Cancer Cells

(2009) Yong Zhao et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres

(2009) J. Sun et al.   GENES & DEVELOPMENT

A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells

(2009) Darren E. Casteel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OB Fold-containing Protein 1 (OBFC1), a Human Homolog of Yeast Stn1, Associates with TPP1 and Is Implicated in Telomere Length Regulation

(2009) Ma Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

(2009) Yasuyuki Miyake et al.   MOLECULAR CELL

Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes

(2009) Yulia V. Surovtseva et al.   MOLECULAR CELL

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

Yeast telomere capping protein Stn1 overrides DNA replication control through the S phase checkpoint

(2009) H. J. Gasparyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain

(2009) A. D. Gelinas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition

(2008) Andrea Puglisi et al.   EMBO JOURNAL