Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol

(2019) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diagnosis and Management of Statin Intolerance

(2019) Rodrigo Alonso et al.   Journal of Atherosclerosis and Thrombosis

Functional role of gut microbiota and PCSK9 in the pathogenesis of diabetes mellitus and cardiovascular disease

(2019) Marco Bruno Morelli et al.   ATHEROSCLEROSIS

Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink

(2019) Daniel F. Carr et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing

(2019) James S. Floyd et al.   PLoS One

Effects of Statins on Memory, Cognition, and Brain Volume in the Elderly

(2019) Katherine Samaras et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of different types of statins on kidney function decline and proteinuria: a network meta-analysis

(2019) K. Esmeijer et al.   Scientific Reports

Statin-specific inhibition of Rab-GTPase regulates cPKC-mediated IKs internalization

(2019) Elsa Ronzier et al.   Scientific Reports

Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications

(2019) Armita Mahdavi Gorabi et al.   Journal of Clinical Medicine

Characteristics and Outcomes of Patients Treated With Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors (The Mayo Clinic Experience)

(2019) Ohad Oren et al.   AMERICAN JOURNAL OF CARDIOLOGY

Atorvastatin inhibits pyroptosis through the lncRNA NEXN-AS1/NEXN pathway in human vascular endothelial cells

(2019) Li-Mei Wu et al.   ATHEROSCLEROSIS

Statins Reverse Postpartum Cardiovascular Dysfunction in a Rat Model of Preeclampsia

(2019) Kristin Kräker et al.   HYPERTENSION

Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites

(2018) Xue Bai et al.   ACTA PHARMACOLOGICA SINICA

The Role of PCSK9 Inhibitors in the Treatment of Hypercholesterolemia

(2018) Roshni S. Patel et al.   ANNALS OF PHARMACOTHERAPY

Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence

(2018) Liam R Brunham et al.   CARDIOVASCULAR RESEARCH

Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins: Pre-Specified Secondary End Points in ORION 1

(2018) Kausik K. Ray et al.   CIRCULATION

Effect of atorvastatin on the gut microbiota of high fat diet-induced hypercholesterolemic rats

(2018) Tariq Jamal Khan et al.   Scientific Reports

Immune-Mediated Necrotizing Myopathy

(2018) Iago Pinal-Fernandez et al.   Current Rheumatology Reports

Extensive impact of non-antibiotic drugs on human gut bacteria

(2018) Lisa Maier et al.   NATURE

Association between SLCO1B1 T521C polymorphism and risk of statin-induced myopathy: a meta-analysis

(2018) Qian Xiang et al.   PHARMACOGENOMICS JOURNAL

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

(2018) Gregory G. Schwartz et al.   NEW ENGLAND JOURNAL OF MEDICINE

RYR1 and CACNA1S genetic variants identified with statin-associated muscle symptoms

(2018) Paul J Isackson et al.   PHARMACOGENOMICS

A common missense variant of LILRB5 is associated with statin intolerance and myalgia

(2017) Moneeza K Siddiqui et al.   EUROPEAN HEART JOURNAL

The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study

(2017) Magnus Asping et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

SLCO1B1 521T > C polymorphism associated with rosuvastatin-induced myotoxicity in Chinese coronary artery disease patients: a nested case–control study

(2017) Ju-E Liu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome

(2017) Richard M. Turner et al.   Journal of Clinical Lipidology

The effects of statins on exercise and physical activity

(2017) Adam M. Noyes et al.   Journal of Clinical Lipidology

Association of miR-145 With Statin-Induced Skeletal Muscle Toxicity in Human Rhabdomyosarcoma RD Cells

(2017) Shun Saito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase

(2017) Ajay Gupta et al.   LANCET

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

(2017) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge

(2017) Marshall B. Elam et al.   PLoS One

Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease: A Scientific Statement From the American Heart Association

(2016) Barbara S. Wiggins et al.   CIRCULATION

Effect of statins on serum vitamin D concentrations: a systematic review and meta-analysis

(2016) Mohsen Mazidi et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Rare genetic variants in cellular transporters, metabolic enzymes and nuclear receptors can be important determinants of interindividual differences in drug response

(2016) Mikael Kozyra et al.   GENETICS IN MEDICINE

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance

(2016) Steven E. Nissen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Influence of statins on distinct circulating microRNAs during prolonged aerobic exercise

(2016) Pil-Ki Min et al.   JOURNAL OF APPLIED PHYSIOLOGY

Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study

(2016) Leon van Haandel et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Interpretation of the evidence for the efficacy and safety of statin therapy

(2016) Rory Collins et al.   LANCET

Statin-Associated Autoimmune Myopathy

(2016) Andrew L. Mammen   NEW ENGLAND JOURNAL OF MEDICINE

CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing

(2016) Danxin Wang et al.   Pharmacogenetics and Genomics

A randomized trial of coenzyme Q10 in patients with confirmed Statin Myopathy

(2015) Beth A. Taylor et al.   ATHEROSCLEROSIS

The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity

(2015) Annalisa Bonifacio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

(2015) Tom J.J. Schirris et al.   Cell Metabolism

GATM Polymorphism Associated with the Risk for Statin-Induced Myopathy Does Not Replicate in Case-Control Analysis of 715 Dyslipidemic Individuals

(2015) Jasmine A. Luzum et al.   Cell Metabolism

Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

(2015) Erik S. Stroes et al.   EUROPEAN HEART JOURNAL

Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect?

(2015) Bruce K. Birmingham et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

(2015) Maciej Banach et al.   Expert Opinion On Drug Safety

Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 patients

(2015) Marta Michalska-Kasiczak et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial

(2015) Patrick M. Moriarty et al.   Journal of Clinical Lipidology

Effects of Coenzyme Q10 on Statin-Induced Myopathy

(2015) Maciej Banach et al.   MAYO CLINIC PROCEEDINGS

Statin Lactonization by Uridine 5′-Diphospho-glucuronosyltransferases (UGTs)

(2015) Tom J. J. Schirris et al.   MOLECULAR PHARMACEUTICS

Clinical and genetic associations of autoantibodies to 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase in patients with immune-mediated myositis and necrotizing myopathy

(2015) Vidya Limaye et al.   MUSCLE & NERVE

Ensembl 2016

(2015) Andrew Yates et al.   NUCLEIC ACIDS RESEARCH

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid

(2015) Aleksi Tornio et al.   Pharmacogenetics and Genomics

Impact of CYP2D6, CYP3A5, CYP2C19, CYP2A6, SLCO1B1, ABCB1, and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin acid

(2015) Hee Youn Choi et al.   Pharmacogenetics and Genomics

ABCG2gene polymorphisms as risk factors for atorvastatin adverse reactions: a case–control study

(2015) Nikica Mirošević Skvrce et al.   PHARMACOGENOMICS

Mechanisms and assessment of statin-related muscular adverse effects

(2014) Dirk Moßhammer et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Impact of statin adherence on cardiovascular disease and mortality outcomes: a systematic review

(2014) Mary A. De Vera et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Drug-Induced Rhabdomyolysis: From Systems Pharmacology Analysis to Biochemical Flux

(2014) Junguk Hur et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications

(2014) Daniel D. Bikle   CHEMISTRY & BIOLOGY

CKM and LILRB5 Are Associated With Serum Levels of Creatine Kinase

(2014) M.-P. Dube et al.   Circulation-Cardiovascular Genetics

Identification of the Effect of Multiple Polymorphisms on the Pharmacokinetics of Simvastatin and Simvastatin Acid Using a Population-Modeling Approach

(2014) N Tsamandouras et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy: 2014 Update

(2014) L B Ramsey et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Phenotype Standardization for Statin-Induced Myotoxicity

(2014) A Alfirevic et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Association between statin-induced creatine kinase elevation and genetic polymorphisms in SLCO1B1, ABCB1 and ABCG2

(2014) Marco Ferrari et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

An assessment by the Statin Muscle Safety Task Force: 2014 update

(2014) Robert S. Rosenson et al.   Journal of Clinical Lipidology

Anti-PCSK9 Antibody Effectively Lowers Cholesterol in Patients With Statin Intolerance

(2014) Erik Stroes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

GATM gene variants and statin myopathy risk

(2014) D. F. Carr et al.   NATURE

GATM locus does not replicate in rhabdomyolysis study

(2014) James S. Floyd et al.   NATURE

CYP3A4*22 and CYP3A5*3 are associated with increased levels of plasma simvastatin concentrations in the cholesterol and pharmacogenetics study cohort

(2014) Joseph P. Kitzmiller et al.   Pharmacogenetics and Genomics

Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

(2014) Clotilde Wiel et al.   Nature Communications

Adverse effects of statins

(2014) Fiona Godlee   BMJ-British Medical Journal

Statins and Physical Activity in Older Men

(2014) David S. H. Lee et al.   JAMA Internal Medicine

Lack of association between SLCO1B1 polymorphisms and clinical myalgia following rosuvastatin therapy

(2013) Jacqueline S. Danik et al.   AMERICAN HEART JOURNAL

Another Side to Statin-Related Side Effects

(2013) Hans Knoblauch   ANNALS OF INTERNAL MEDICINE

Statin Toxicity From Macrolide Antibiotic Coprescription

(2013) Amit M. Patel et al.   ANNALS OF INTERNAL MEDICINE

Discontinuation of Statins in Routine Care Settings

(2013) Huabing Zhang et al.   ANNALS OF INTERNAL MEDICINE

Intermittent Nondaily Dosing Strategies in Patients with Previous Statin-Induced Myopathy

(2013) Alyssa J Keating et al.   ANNALS OF PHARMACOTHERAPY

Clinical and Pharmacogenetic Predictors of Circulating Atorvastatin and Rosuvastatin Concentrations in Routine Clinical Care

(2013) Marianne K. DeGorter et al.   Circulation-Cardiovascular Genetics

SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink

(2013) D F Carr et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset

(2013) A. S. Gordon et al.   HUMAN MOLECULAR GENETICS

Predictors of statin adherence, switching, and discontinuation in the USAGE survey: Understanding the use of statins in America and gaps in patient education

(2013) Melissa Y. Wei et al.   Journal of Clinical Lipidology

UGT1A1*28 is Associated with Decreased Systemic Exposure of Atorvastatin Lactone

(2013) Camilla Stormo et al.   Molecular Diagnosis & Therapy

A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

(2013) Lara M. Mangravite et al.   NATURE

The Transformer database: biotransformation of xenobiotics

(2013) Michael F. Hoffmann et al.   NUCLEIC ACIDS RESEARCH

The SLCO1B1 c.521T>C polymorphism is associated with dose decrease or switching during statin therapy in the Rotterdam Study

(2013) Catherine E. de Keyser et al.   Pharmacogenetics and Genomics

CYP2C9andABCG2polymorphisms as risk factors for developing adverse drug reactions in renal transplant patients taking fluvastatin: a case–control study

(2013) Nikica Miroševic Skvrce et al.   PHARMACOGENOMICS

Statin-Induced Rhabdomyolysis: A Comprehensive Review of Case Reports

(2013) Polyana Mendes et al.   Physiotherapy Canada

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

(2013) Anne T Nies et al.   Genome Medicine

Adherence to Drugs That Prevent Cardiovascular Disease: Meta-analysis on 376,162 Patients

(2012) Sayed H. Naderi et al.   AMERICAN JOURNAL OF MEDICINE

Effects of Statins on Energy and Fatigue With Exertion: Results From a Randomized Controlled Trial

(2012) Beatrice A. Golomb et al.   ARCHIVES OF INTERNAL MEDICINE

Antibody levels correlate with creatine kinase levels and strength in anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase-associated autoimmune myopathy

(2012) Jessie L. Werner et al.   ARTHRITIS AND RHEUMATISM

Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation

(2012) Ranjit K. Thirumaran et al.   BIOCHEMICAL PHARMACOLOGY

Effect of Statins on Skeletal Muscle Function

(2012) Beth A. Parker et al.   CIRCULATION

Understanding the Critical Disposition Pathways of Statins to Assess Drug–Drug Interaction Risk During Drug Development: It's Not Just About OATP1B1

(2012) R Elsby et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

(2012) Kathrin Klein et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impact of CYP2D6 polymorphisms on the pharmacokinetics of lovastatin in Chinese subjects

(2012) Ophelia Qi Ping Yin et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Effect of Statins on Skeletal Muscle

(2012) Beth A. Parker et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Calmodulin-binding Locations on the Skeletal and Cardiac Ryanodine Receptors

(2012) Xiaojun Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk of hospitalized rhabdomyolysis associated with lipid-lowering drugs in a real-world clinical setting

(2012) Mark J. Cziraky et al.   Journal of Clinical Lipidology

Interplay between vitamin D and the drug metabolizing enzyme CYP3A4

(2012) Zhican Wang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mitochondria of trained skeletal muscle are protected from deleterious effects of statins

(2012) Jamal Bouitbir et al.   MUSCLE & NERVE

The UGT1A3*2 polymorphism affects atorvastatin lactonization and lipid-lowering effect in healthy volunteers

(2012) Sung Kweon Cho et al.   Pharmacogenetics and Genomics

Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives

(2012) Iris Postmus et al.   PHARMACOGENOMICS

CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy

(2012) Laure Elens et al.   PHARMACOGENOMICS

A Small-Molecule Screening Strategy To Identify Suppressors of Statin Myopathy

(2011) Bridget K. Wagner et al.   ACS Chemical Biology

Effect of Statins on Creatine Kinase Levels Before and After a Marathon Run

(2011) Beth A. Parker et al.   AMERICAN JOURNAL OF CARDIOLOGY

Mechanisms of statin-induced myalgia assessed by physiogenomic associations

(2011) Gualberto Ruaño et al.   ATHEROSCLEROSIS

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

(2011) Peter J. Mullen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Primary and secondary CoQ10 deficiencies in humans

(2011) Catarina M. Quinzii et al.   BIOFACTORS

SLCO1B1 haplotypes are not associated with atorvastatin-induced myalgia in Brazilian patients with familial hypercholesterolemia

(2011) Paulo Caleb Junior Lima Santos et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Statin-induced myopathy: a review and update

(2011) Thura T Abd et al.   Expert Opinion On Drug Safety

Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes

(2011) Hyo-Bum Kwak et al.   FREE RADICAL BIOLOGY AND MEDICINE

The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort

(2011) Michel R. Hoenig et al.   Journal of Clinical Lipidology

Genetic risk for malignant hyperthermia in non-anesthesia-induced myopathies

(2011) Georgirene D. Vladutiu et al.   MOLECULAR GENETICS AND METABOLISM

Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: Evidence for additional functions of EYS

(2011) Paul J. Isackson et al.   MUSCLE & NERVE

Cerivastatin, genetic variants, and the risk of rhabdomyolysis

(2011) Kristin D. Marciante et al.   Pharmacogenetics and Genomics

Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin

(2011) L R Brunham et al.   PHARMACOGENOMICS JOURNAL

Effect of Cytochrome P450 3A5 Genotype on Atorvastatin Pharmacokinetics and Its Interaction with Clarithromycin

(2011) Jaekyu Shin et al.   PHARMACOTHERAPY

Impact ofSLCO1B1(OATP1B1) andABCG2(BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins

(2011) Grant T. Generaux et al.   XENOBIOTICA

A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy

(2010) Lisa Christopher-Stine et al.   ARTHRITIS AND RHEUMATISM

Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy

(2010) Andrew L. Mammen et al.   ARTHRITIS AND RHEUMATISM

Genetic involvement in statins induced myopathy. Preliminary data from an observational case–control study

(2010) Luca Puccetti et al.   ATHEROSCLEROSIS

The relationship of vitamin D deficiency to statin myopathy

(2010) Ankur Gupta et al.   ATHEROSCLEROSIS

Pitavastatin – pharmacological profile from early phase studies

(2010) Alberico L. Catapano   ATHEROSCLEROSIS SUPPLEMENTS

Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go-DARTS Study

(2010) L A Donnelly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Statin-associated myopathy and its exacerbation with exercise

(2010) Benjamin M. Meador et al.   MUSCLE & NERVE

Neuromuscular Symptoms and Elevated Creatine Kinase after Statin Withdrawal

(2010) Andoni Echaniz-Laguna et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs

(2010) D Wang et al.   PHARMACOGENOMICS JOURNAL

Statin Adverse Effects

(2009) Beatrice A Golomb et al.   American Journal of Cardiovascular Drugs

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy

(2009) Peter James Mullen et al.   BIOCHEMICAL PHARMACOLOGY

Association between statin-associated myopathy and skeletal muscle damage

(2009) M. G. Mohaupt et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins

(2009) Michael J. Knauer et al.   CIRCULATION RESEARCH

UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo

(2009) S Riedmaier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect

(2009) Peirang Cao et al.   FASEB JOURNAL

Possible Mechanisms Underlying Statin-Induced Skeletal Muscle Toxicity in L6 Fibroblasts and in Rats

(2009) Mai Itagaki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The SLCO1B1*5Genetic Variant Is Associated With Statin-Induced Side Effects

(2009) Deepak Voora et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Immune-mediated necrotizing myopathy associated with statins

(2009) Phyllis Grable-Esposito et al.   MUSCLE & NERVE

Influence of genetic variation inCYP3A4andABCB1on dose decrease or switching during simvastatin and atorvastatin therapy

(2009) Matthijs L. Becker et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes

(2009) Katalin Jemnitz et al.   TOXICOLOGY IN VITRO

Mutations in LPIN1 Cause Recurrent Acute Myoglobinuria in Childhood

(2008) Avraham Zeharia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pharmacokinetic Comparison of the Potential Over-the-Counter Statins Simvastatin, Lovastatin, Fluvastatin and Pravastatin

(2008) Pertti J Neuvonen et al.   CLINICAL PHARMACOKINETICS

Effects of Vitamin D Supplementation in Atorvastatin-Treated Patients: A New Drug Interaction With an Unexpected Consequence

(2008) JB Schwartz   CLINICAL PHARMACOLOGY & THERAPEUTICS

ABCB1 Haplotypes Differentially Affect the Pharmacokinetics of the Acid and Lactone Forms of Simvastatin and Atorvastatin

(2008) JE Keskitalo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin

(2008) S. Kitamura et al.   DRUG METABOLISM AND DISPOSITION

Statin induced myotoxicity: The lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro

(2008) Ine Blankenberg Skottheim et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Large-scale chemical dissection of mitochondrial function

(2008) Bridget K Wagner et al.   NATURE BIOTECHNOLOGY

Early Coenzyme Q10 Supplementation in Primary Coenzyme Q10 Deficiency

(2008) Giovanni Montini et al.   NEW ENGLAND JOURNAL OF MEDICINE

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Myotoxicity of Lipid-Lowering Agents in a Teenager With MELAS Mutation

(2008) Stacey K.H. Tay et al.   PEDIATRIC NEUROLOGY

BCRP/ABCG2 in the Placenta: Expression, Function and Regulation

(2008) Qingcheng Mao   PHARMACEUTICAL RESEARCH

Low serum 25 (OH) vitamin D levels (

(2008) Waqas Ahmed et al.   Translational Research

Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin

(2008) J.-E. Park et al.   XENOBIOTICA