Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions

(2012) John D Clarke et al.   Expert Opinion on Drug Metabolism & Toxicology

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

(2012) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of drug transporter expression by oncostatin M in human hepatocytes

(2011) Marc Le Vee et al.   BIOCHEMICAL PHARMACOLOGY

Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

(2011) L. B. Ramsey et al.   GENOME RESEARCH

Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs

(2011) Florie Borel et al.   HEPATOLOGY

Pharmacogenetics of OATP Transporters Reveals That SLCO1B1 c.388A>G Variant Is Determinant of Increased Atorvastatin Response

(2011) Alice C. Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake

(2011) M. Niemi et al.   PHARMACOLOGICAL REVIEWS

Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)

(2011) Anne T. Nies et al.   PLoS One

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

(2011) Elke Schaeffeler et al.   Genome Medicine

Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go-DARTS Study

(2010) L A Donnelly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters

(2010) Hiroyuki Kusuhara et al.   DRUG METABOLISM REVIEWS

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1

(2010) Henriette E. Meyer zu Schwabedissen et al.   HEPATOLOGY

A Synonymous Single Nucleotide Polymorphism in ΔF508CFTRAlters the Secondary Structure of the mRNA and the Expression of the Mutant Protein

(2010) Rafal A. Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Differential effect of genetic variants of Na+-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors

(2010) Min-Koo Choi et al.   XENOBIOTICA

ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin

(2009) J E Keskitalo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic Variations of the SLCO1B1 Gene in the Chinese, Malay and Indian Populations of Singapore

(2009) Woon Fei Ho et al.   Drug Metabolism and Pharmacokinetics

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

(2009) Anne T. Nies et al.   HEPATOLOGY

New molecular insights into the mechanisms of cholestasis

(2009) Martin Wagner et al.   JOURNAL OF HEPATOLOGY

Transcriptional control of human organic anion transporting polypeptide 2B1 gene

(2009) Elena Pomari et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The SLCO1B1*5Genetic Variant Is Associated With Statin-Induced Side Effects

(2009) Deepak Voora et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Highly Multiplexed Genotyping of Thiopurine S-Methyltransferase Variants Using MALDI-TOF Mass Spectrometry: Reliable Genotyping in Different Ethnic Groups

(2008) E. Schaeffeler et al.   CLINICAL CHEMISTRY

ABCB1 Haplotypes Differentially Affect the Pharmacokinetics of the Acid and Lactone Forms of Simvastatin and Atorvastatin

(2008) JE Keskitalo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3

(2008) Chunshan Gui et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs

(2008) Anne T Nies et al.   Expert Opinion on Drug Metabolism & Toxicology

Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide

(2008) Annikka Kalliokoski et al.   Pharmacogenetics and Genomics