Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge

Oct-1, to go or not to go? That is the PolII question

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Clinical Profile of Statin Intolerance in the Phase 3 GAUSS-2 Study

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Statin-Associated Autoimmune Myopathy

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Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

(2015) Tom J.J. Schirris et al.   Cell Metabolism

GATM Polymorphism Associated with the Risk for Statin-Induced Myopathy Does Not Replicate in Case-Control Analysis of 715 Dyslipidemic Individuals

(2015) Jasmine A. Luzum et al.   Cell Metabolism

Risk identification and possible countermeasures for muscle adverse effects during statin therapy

(2015) Paolo Magni et al.   European Journal of Internal Medicine

Immune-mediated statin myopathy

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Differential expression ofHDACandHATgenes in atrophying skeletal muscle

(2015) Adam W. Beharry et al.   MUSCLE & NERVE

Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content

(2015) Craig A. Goodman et al.   PLoS One

The proinflammatory role of HECTD2 in innate immunity and experimental lung injury

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p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3

(2015) Sabine Hünten et al.   Oncotarget

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

(2015) Gaetano Santulli et al.   Current Molecular Pharmacology

p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

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Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Disease Risk in Adults: Synopsis of the 2013 American College of Cardiology/American Heart Association Cholesterol Guideline

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Identification of the Effect of Multiple Polymorphisms on the Pharmacokinetics of Simvastatin and Simvastatin Acid Using a Population-Modeling Approach

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GATM gene variants and statin myopathy risk

(2014) D. F. Carr et al.   NATURE

GATM locus does not replicate in rhabdomyolysis study

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Statins and skeletal muscles toxicity: From clinical trials to everyday practice

(2014) Giuseppe Danilo Norata et al.   PHARMACOLOGICAL RESEARCH

Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

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Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle

(2014) Jennifer S. Moylan et al.   Redox Biology

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

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Calcineurin: A poorly understood regulator of muscle mass

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Proteomic and Functional Analyses Reveal the Role of Chromatin Reader SFMBT1 in Regulating Epigenetic Silencing and the Myogenic Gene Program

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A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

(2013) Lara M. Mangravite et al.   NATURE

Statin myotoxicity: A review of genetic susceptibility factors

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Eicosapentaenoic acid attenuates statin-induced ER stress and toxicity in myoblast

(2012) Masahiko Ohta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells

(2012) Gipsy Majumdar et al.   BMC GENOMICS

Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver

(2012) Angela M. Hall et al.   JOURNAL OF LIPID RESEARCH

Individualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutions

(2012) QiPing Feng et al.   PHARMACOGENOMICS

Clinical and laboratory phenotype of patients experiencing statin intolerance attributable to myalgia

(2011) Leonard J. Harris et al.   Journal of Clinical Lipidology

The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort

(2011) Michel R. Hoenig et al.   Journal of Clinical Lipidology

The diversity of sex steroid action: novel functions of hydroxysteroid (17β) dehydrogenases as revealed by genetically modified mouse models

(2011) Taija Saloniemi et al.   JOURNAL OF ENDOCRINOLOGY

Cerivastatin, genetic variants, and the risk of rhabdomyolysis

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Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go-DARTS Study

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Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

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miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1

(2010) Jian-Xun Wang et al.   NATURE MEDICINE

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

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The genetics of statin-induced myopathy

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Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins

(2009) Michael J. Knauer et al.   CIRCULATION RESEARCH

Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect

(2009) Peirang Cao et al.   FASEB JOURNAL

Omigapil Ameliorates the Pathology of Muscle Dystrophy Caused by Laminin- 2 Deficiency

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Hepatic Gene Expression in Morbidly Obese Women: Implications for Disease Susceptibility

(2009) Marshall B. Elam et al.   Obesity

Muscle expression of genes associated with inflammation, growth, and remodeling is strongly correlated in older adults with resistance training outcomes

(2009) Richard A. Dennis et al.   PHYSIOLOGICAL GENOMICS

Genetic predisposition to statin myopathy

(2008) Georgirene D Vladutiu   CURRENT OPINION IN RHEUMATOLOGY

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

SGNP: An Essential Stress Granule/Nucleolar Protein Potentially Involved in 5.8s rRNA Processing/Transport

(2008) Chun-Hong Zhu et al.   PLoS One

Low serum 25 (OH) vitamin D levels (

(2008) Waqas Ahmed et al.   Translational Research