Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

A meta-analysis of randomized controlled trials on statins for the prevention of contrast-induced acute kidney injury in patients with and without acute coronary syndromes

(2015) Giancarlo Marenzi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 patients

(2015) Marta Michalska-Kasiczak et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Statin use increases the risk of depressive disorder in stroke patients: A population-based study

(2015) Jiunn-Horng Kang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effects of Coenzyme Q10 on Statin-Induced Myopathy

(2015) Maciej Banach et al.   MAYO CLINIC PROCEEDINGS

Lipid Management in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2013 Clinical Practice Guideline

(2014) Marcello Tonelli et al.   ANNALS OF INTERNAL MEDICINE

Statins and New-Onset Diabetes

(2014) Marcin Barylski et al.   CURRENT PHARMACEUTICAL DESIGN

New ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management

(2014) Steen D. Kristensen et al.   EUROPEAN HEART JOURNAL

Subclinical hypothyroidism and vascular risk: Αn update

(2014) Eirini Lioudaki et al.   Hormones-International Journal of Endocrinology and Metabolism

Lipid, blood pressure and kidney update 2013

(2014) Maciej Banach et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Comparison of Application of the ACC/AHA Guidelines, Adult Treatment Panel III Guidelines, and European Society of Cardiology Guidelines for Cardiovascular Disease Prevention in a European Cohort

(2014) Maryam Kavousi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Proprotein Convertase Subtilisin/Kexin 9 Inhibitors

(2014) Simona Dragan et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation

(2014) Joo Young Huh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Efficacy and safety of alirocumab, a monoclonal antibody to PCSK9, in statin-intolerant patients: Design and rationale of ODYSSEY ALTERNATIVE, a randomized phase 3 trial

(2014) Patrick M. Moriarty et al.   Journal of Clinical Lipidology

An assessment by the Statin Muscle Safety Task Force: 2014 update

(2014) Robert S. Rosenson et al.   Journal of Clinical Lipidology

An assessment by the Statin Liver Safety Task Force: 2014 update

(2014) Harold Bays et al.   Journal of Clinical Lipidology

An assessment by the Statin Intolerance Panel: 2014 update

(2014) John R. Guyton et al.   Journal of Clinical Lipidology

The Effect of Statins on Erectile Dysfunction: A Meta‐Analysis of Randomized Trials

(2014) John B. Kostis et al.   Journal of Sexual Medicine

Anti-PCSK9 Antibody Effectively Lowers Cholesterol in Patients With Statin Intolerance

(2014) Erik Stroes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Resistance and intolerance to statins

(2014) Ž. Reiner   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Patient attitudes towards a new role for pharmacists: continued dispensing

(2014) Salam hasn Abukres et al.   Patient Preference and Adherence

What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice

(2014) Judith A Finegold et al.   European Journal of Preventive Cardiology

Different Time Trends of Caloric and Fat Intake Between Statin Users and Nonusers Among US Adults

(2014) Takehiro Sugiyama et al.   JAMA Internal Medicine

Alcohol Screening Scores and Medication Nonadherence

(2013) Chris L. Bryson   ANNALS OF INTERNAL MEDICINE

Narrative Review: Statin-Related Myopathy

(2013) Tisha R. Joy   ANNALS OF INTERNAL MEDICINE

Statins and cardiovascular outcomes in elderly and younger patients with coronary artery disease: a post hoc analysis of the GREACE study

(2013) Vasilios G. Athyros et al.   Archives of Medical Science

Editorial Statin treatment in the elderly: how much do we know?

(2013) Manfredi Rizzo et al.   Archives of Medical Science

The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials

(2013) C Mary Schooling et al.   BMC Medicine

Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Working Group Consensus Update

(2013) G.B. John Mancini et al.   CANADIAN JOURNAL OF CARDIOLOGY

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

(2013) Neil J. Stone et al.   CIRCULATION

Are statins ‘IDEAL’ for non-alcoholic fatty liver disease?

(2013) Vasilios G. Athyros et al.   CURRENT MEDICAL RESEARCH AND OPINION

Statin Therapy and New-onset Diabetes: Molecular Mechanisms and Clinical Relevance

(2013) Maciej Banach et al.   CURRENT PHARMACEUTICAL DESIGN

Intolerance to Statins: Mechanisms and Management

(2013) R. Bitzur et al.   DIABETES CARE

Two Cases of Statin-Induced Myopathy Caused by Induced Hypothyroidism

(2013) Howard Lando et al.   Endocrine Practice

HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment

(2013) et al.   EUROPEAN HEART JOURNAL

Statin use and risk of hepatocellular carcinoma

(2013) Shih-Wei Lai et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

A meta-analysis of the role of statins on renal outcomes in patients with chronic kidney disease. Is the duration of therapy important?

(2013) Dragana Nikolic et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels

(2013) Matti J. Tikkanen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Predictors of statin adherence, switching, and discontinuation in the USAGE survey: Understanding the use of statins in America and gaps in patient education

(2013) Melissa Y. Wei et al.   Journal of Clinical Lipidology

Statins, Exercise, and Exercise Training∗

(2013) Paul D. Thompson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis

(2013) William J. Cash et al.   LIVER INTERNATIONAL

Statin myotoxicity: A review of genetic susceptibility factors

(2013) M. Needham et al.   NEUROMUSCULAR DISORDERS

Statins decrease all-cause mortality only in CKD patients not requiring dialysis therapy—A meta-analysis of 11 randomized controlled trials involving 21,295 participants

(2013) Marcin Barylski et al.   PHARMACOLOGICAL RESEARCH

Fluvastatin Interferes with Hepatitis C Virus Replication via Microtubule Bundling and a Doublecortin-like Kinase-Mediated Mechanism

(2013) Naushad Ali et al.   PLoS One

Perioperative pleiotropic statin effects in general surgery

(2013) James C. Iannuzzi et al.   SURGERY

Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases

(2013) C. R. Dormuth et al.   BMJ-British Medical Journal

Risk of incident diabetes among patients treated with statins: population based study

(2013) A. A. Carter et al.   BMJ-British Medical Journal

Association of Statin Use With Cataracts

(2013) Jessica Leuschen et al.   JAMA Ophthalmology

FDA Drug Safety Communications: A Narrative Review and Clinical Considerations for Older Adults

(2012) Zachary A. Marcum et al.   American Journal Geriatric Pharmacotherapy

Statin Use and Musculoskeletal Pain Among Adults With and Without Arthritis

(2012) Catherine Buettner et al.   AMERICAN JOURNAL OF MEDICINE

State of the art papers Lipids, blood pressure, kidney – what was new in 2011?

(2012) Marcin Barylski et al.   Archives of Medical Science

Safety and impact on cardiovascular events of long-term multifactorial treatment in patients with metabolic syndrome and abnormal liver function tests: a post hoc analysis of the randomised ATTEMPT study

(2012) Vassilios G. Athyros et al.   Archives of Medical Science

Effect of Statins on Skeletal Muscle Function

(2012) Beth A. Parker et al.   CIRCULATION

Statin use and risk of diabetes mellitus in postmenopausal women

(2012) Niki Katsiki et al.   Clinical Lipidology

Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD

(2012) Amedeo Lonardo et al.   CURRENT PHARMACEUTICAL DESIGN

Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial

(2012) Maartje E. Visser et al.   EUROPEAN HEART JOURNAL

Statins and primary liver cancer

(2012) Danitza Pradelli et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Statin-associated gynecomastia: evidence coming from the Italian spontaneous ADR reporting database and literature

(2012) Giuseppe Roberto et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Statins Are Associated With a Reduced Risk of Hepatocellular Cancer: A Systematic Review and Meta-analysis

(2012) Siddharth Singh et al.   GASTROENTEROLOGY

Effect of a Monoclonal Antibody to PCSK9 on Low-Density Lipoprotein Cholesterol Levels in Statin-Intolerant Patients

(2012) David Sullivan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Smoking and non-alcoholic steatohepatitis (NASH): The GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) trial

(2012) Niki Katsiki et al.   JOURNAL OF HEPATOLOGY

Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial

(2012) Paul M Ridker et al.   LANCET

Interactive effects of fitness and statin treatment on mortality risk in veterans with dyslipidaemia: a cohort study

(2012) Peter F Kokkinos et al.   LANCET

Statin-induced lupus: a case/non-case study in a nationwide pharmacovigilance database

(2012) G Moulis et al.   LUPUS

Toward “Pain-Free” Statin Prescribing: Clinical Algorithm for Diagnosis and Management of Myalgia

(2012) Terry A. Jacobson   MAYO CLINIC PROCEEDINGS

Statin-Associated Polymyalgia Rheumatica. An Analysis Using WHO Global Individual Case Safety Database: A Case/Non-Case Approach

(2012) Hilda J. I. de Jong et al.   PLoS One

Clinical Practice Guidelines for Hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association

(2012) Jeffrey R. Garber et al.   THYROID

Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins

(2012) P. Sirvent et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Impact of statin discontinuation on mortality in patients with rheumatoid arthritis: A population-based study

(2012) Mary A. De Vera et al.   ARTHRITIS CARE & RESEARCH

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)

(2012)   European Journal of Preventive Cardiology

Effect of Statins on Creatine Kinase Levels Before and After a Marathon Run

(2011) Beth A. Parker et al.   AMERICAN JOURNAL OF CARDIOLOGY

Statin-based treatment for cardiovascular risk and non-alcoholic fatty liver disease. Killing two birds with one stone?

(2011) Vasilios G. Athyros et al.   ANNALS OF MEDICINE

Use of statins is associated with an increased risk of rheumatoid arthritis

(2011) H J I de Jong et al.   ANNALS OF THE RHEUMATIC DISEASES

Prevention of Atherosclerosis in Overweight/Obese Patients

(2011) Soo Lim et al.   CIRCULATION JOURNAL

Jaundice Due to Suspected Statin Hepatotoxicity: A Case Series

(2011) Ottar M. Bergmann et al.   DIGESTIVE DISEASES AND SCIENCES

ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)

(2011) et al.   EUROPEAN HEART JOURNAL

Statin-induced myopathy: a review and update

(2011) Thura T Abd et al.   Expert Opinion On Drug Safety

Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes

(2011) Hyo-Bum Kwak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Yes! Statins can be given to liver patients

(2011) Ted Bader   JOURNAL OF HEPATOLOGY

Hepatotoxicity associated with statins: Reports of idiosyncratic liver injury post-marketing

(2011) Einar Björnsson et al.   JOURNAL OF HEPATOLOGY

Statin Use Associates with a Lower Incidence of Acute Kidney Injury after Major Elective Surgery

(2011) A. O. Molnar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Symptomatic myositis-myalgia in hypercholesterolemic statin-treated patients with concurrent vitamin D deficiency leading to statin intolerance may reflect a reversible interaction between vitamin D deficiency and statins on skeletal muscle

(2011) Charles J. Glueck et al.   MEDICAL HYPOTHESES

Cerivastatin, genetic variants, and the risk of rhabdomyolysis

(2011) Kristin D. Marciante et al.   Pharmacogenetics and Genomics

The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in rheumatologic disorders: a comprehensive review

(2011) Christos G. Mihos et al.   RHEUMATOLOGY INTERNATIONAL

Statins Should Be Used with Greater Caution in Patients Undergoing Thyroid Hormone Withdrawal for Radioactive Iodine Treatment

(2011) Abdallah Al-Salameh et al.   THYROID

Screening Stress Myocardial Perfusion Imaging and Eligibility for Liver Transplantation

(2010) Steven M. Bradley et al.   AMERICAN JOURNAL OF CARDIOLOGY

Atorvastatin and Antioxidants for the Treatment of Nonalcoholic Fatty Liver Disease: The St Francis Heart Study Randomized Clinical Trial

(2010) Temitope Foster et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go-DARTS Study

(2010) L A Donnelly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The tolerability and efficacy of low-dose simvastatin in statin-intolerant patients

(2010) L.E. Degreef et al.   European Journal of Internal Medicine

Statins in patients with chronic kidney disease: why, who and when?

(2010) Anna Gluba et al.   EXPERT OPINION ON PHARMACOTHERAPY

A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease

(2010) Giovanni Musso et al.   HEPATOLOGY

Liver tests are irrelevant when prescribing statins

(2010) Ted Bader   LANCET

Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

(2010) Vasilios G Athyros et al.   LANCET

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12 064 survivors of myocardial infarction: a double-blind randomised trial

(2010)   LANCET

Statin-associated myopathy and its exacerbation with exercise

(2010) Benjamin M. Meador et al.   MUSCLE & NERVE

The role of Toll-like receptors in renal diseases

(2010) Anna Gluba et al.   Nature Reviews Nephrology

Statin Adverse Effects

(2009) Beatrice A Golomb et al.   American Journal of Cardiovascular Drugs

Updates on Cytochrome P450-Mediated Cardiovascular Drug Interactions

(2009) Judy W M Cheng et al.   AMERICAN JOURNAL OF THERAPEUTICS

Statin therapy in the elderly: A review

(2009) Iwona Szadkowska et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Low-dose atorvastatin improves dyslipidemia and vascular function in patients with primary biliary cirrhosis after one year of treatment

(2009) Tatjana Stojakovic et al.   ATHEROSCLEROSIS

Role and significance of statins in the treatment of hypertensive patients

(2009) Mariusz Stepien et al.   CURRENT MEDICAL RESEARCH AND OPINION

Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-Analysis

(2009) S. N. Rajpathak et al.   DIABETES CARE

Statins in Primary Biliary Cirrhosis: Are They Safe?

(2009) Murad Abu Rajab et al.   DIGESTIVE DISEASES AND SCIENCES

Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery

(2009) et al.   EUROPEAN HEART JOURNAL

Nephroprotective and clinical potential of statins in dialyzed patients

(2009) Jacek Rysz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Statins potentiate thein vitroanti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development

(2009) Leen Delang et al.   HEPATOLOGY

Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the Atherosclerosis Risk in Communities Study

(2009) Keri L. Monda et al.   JOURNAL OF LIPID RESEARCH

The creatine kinase response to eccentric exercise with atorvastatin 10mg or 80mg

(2008) Amy K. Kearns et al.   ATHEROSCLEROSIS

Statins and Interstitial Lung Disease

(2008) Antonio B. Fernández et al.   CHEST

Fatty liver, insulin resistance, and dyslipidemia

(2008) Martin Adiels et al.   Current Diabetes Reports

Statin discontinuation: an underestimated risk?

(2008) Konstantinos Tziomalos et al.   CURRENT MEDICAL RESEARCH AND OPINION

New insights into mechanisms of statin-associated myotoxicity

(2008) P SIRVENT et al.   CURRENT OPINION IN PHARMACOLOGY

Statin-Associated Psychiatric Adverse Events

(2008) Marco Tuccori et al.   DRUG SAFETY

Cold Tolerance in Hypothyroid Rabbits: Role of Skeletal Muscle Mitochondria and Sarcoplasmic Reticulum Ca2+ATPase Isoform 1 Heat Production

(2008) Ana Paula Arruda et al.   ENDOCRINOLOGY

Impact of preoperative statin therapy on adverse postoperative outcomes in patients undergoing cardiac surgery: a meta-analysis of over 30 000 patients

(2008) Oliver J. Liakopoulos et al.   EUROPEAN HEART JOURNAL

Intensive Lipid Lowering With Atorvastatin in Patients With Coronary Heart Disease and Chronic Kidney Disease

(2008) James Shepherd et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lipid-Lowering Medication Use and Aggression Scores in Women: A Report from the NHLBI-Sponsored WISE Study

(2008) Marian B. Olson et al.   JOURNAL OF WOMENS HEALTH

Diplopia, Blepharoptosis, and Ophthalmoplegia and 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitor Use

(2008) F.W. Fraunfelder et al.   OPHTHALMOLOGY