Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution

Mitochondrial Homeostasis and Cellular Senescence

(2019) Panagiotis V.S. Vasileiou et al.   Cells

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration

(2019) Thomas Venables et al.   Nature Communications

Iron homeostasis and oxidative stress: An intimate relationship

(2019) Dimitrios Galaris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mini-Review: Oxidative stress, redox stress or redox success ?

(2018) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thymic stromal cells: Roles in atrophy and age-associated dysfunction of the thymus

(2018) Sergio Cepeda et al.   EXPERIMENTAL GERONTOLOGY

ADAPTIVE HOMEOSTASIS AND THE FREE RADICAL THEORY OF AGEING

(2018) Laura C.D. Pomatto et al.   FREE RADICAL BIOLOGY AND MEDICINE

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

(2018) Alexandra Barbouti et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Lipophilic ester and amide derivatives of rosmarinic acid protect cells against H 2 O 2 -induced DNA damage and apoptosis: The potential role of intracellular accumulation and labile iron chelation

(2018) Paraskevi S. Gerogianni et al.   Redox Biology

Oxidative stress and aging: the potential role of iron

(2018) Dimitrios Galaris et al.   Hormones-International Journal of Endocrinology and Metabolism

Senescence and senotherapeutics: a new field in cancer therapy

(2018) Vassilios Myrianthopoulos et al.   PHARMACOLOGY & THERAPEUTICS

Principal Aspects Regarding the Maintenance of Mammalian Mitochondrial Genome Integrity

(2017) Panagiotis Vasileiou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thymic Atrophy: Experimental Studies and Therapeutic Interventions

(2017) S. Majumdar et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The Oxygen Paradox, the French Paradox, and age-related diseases

(2017) Joanna M. S. Davies et al.   GeroScience

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

Robust, universal biomarker assay to detect senescent cells in biological specimens

(2016) Konstantinos Evangelou et al.   AGING CELL

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β

(2016) Eleni Liakou et al.   Aging-US

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

Effect of Different Selenium Supplementation Levels on Oxidative Stress, Cytokines, and Immunotoxicity in Chicken Thymus

(2016) Yachao Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Senescent cell death brings hopes to life

(2016) Yossi Ovadya et al.   CELL CYCLE

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

(2016) Milena Pinto et al.   CELL DEATH AND DIFFERENTIATION

The Pathophysiology of Heme in the Brain

(2016) Raffaella Gozzelino   Current Alzheimer Research

Effects of ageing and senescence on pancreatic β-cell function

(2016) A. Helman et al.   DIABETES OBESITY & METABOLISM

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Intracellular labile iron determines H 2 O 2 -induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis

(2016) M.D. Mantzaris et al.   FREE RADICAL BIOLOGY AND MEDICINE

Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution

(2016) Yoko Hamazaki et al.   IMMUNOLOGICAL REVIEWS

Iron Homeostasis in Health and Disease

(2016) Raffaella Gozzelino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Calorie restriction as an intervention in ageing

(2016) Guillermo López-Lluch et al.   JOURNAL OF PHYSIOLOGY-LONDON

Apoptosis or senescence? Which exit route do epithelial cells and fibroblasts preferentially follow?

(2016) Eleni Georgakopoulou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cellular senescence in renal ageing and disease

(2016) Ines Sturmlechner et al.   Nature Reviews Nephrology

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications

(2016) Xin Gen Lei et al.   PHYSIOLOGICAL REVIEWS

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hydroxytyrosol inhibits hydrogen peroxide-induced apoptotic signaling via labile iron chelation

(2016) Natalia Kitsati et al.   Redox Biology

Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats

(2016) Lidia A. Obukhova et al.   Aging-US

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

(2016) EA Georgakopoulou et al.   Aging-US

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Mitochondria: Are they causal players in cellular senescence?

(2015) Clara Correia-Melo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial responsibility in ageing process: innocent, suspect or guilty

(2015) Guillermo López-Lluch et al.   BIOGERONTOLOGY

High dietary intake of vitamin C suppresses age-related thymic atrophy and contributes to the maintenance of immune cells in vitamin C-deficient senescence marker protein-30 knockout mice

(2015) Ryusei Uchio et al.   BRITISH JOURNAL OF NUTRITION

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Mechanisms linking mtDNA damage and aging

(2015) Milena Pinto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hormonal control of T-cell development in health and disease

(2015) Wilson Savino et al.   Nature Reviews Endocrinology

Antioxidative effect of ginseng stem-leaf saponins on oxidative stress induced by cyclophosphamide in chickens

(2015) J. Yu et al.   POULTRY SCIENCE

Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells

(2015) Nana Akagi Tsuchihashi et al.   Oncotarget

Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency

(2015) Ann V. Griffith et al.   Cell Reports

The importance of iron in pathophysiologic conditions

(2015) Raffaella Gozzelino et al.   Frontiers in Pharmacology

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of selenoprotein W in inflammatory injury in chicken immune tissues and cultured splenic lymphocyte

(2014) Dong Yu et al.   BIOMETALS

Physiological and pathological consequences of cellular senescence

(2014) Dominick G. A. Burton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein Oxidation and Proteolytic Signalling in Aging

(2014) Christiane Ott et al.   CURRENT PHARMACEUTICAL DESIGN

Revisiting an age-old question regarding oxidative stress

(2014) Yael H. Edrey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Autophagy in T-cell development, activation and differentiation

(2014) Alisha W Bronietzki et al.   IMMUNOLOGY AND CELL BIOLOGY

Role of Metabolic H2O2Generation

(2014) Helmut Sies   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Saponins fromAralia taibaiensisAttenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways

(2014) Ying-Na Li et al.   Oxidative Medicine and Cellular Longevity

Labile iron in cells and body fluids: physiology, pathology, and pharmacology

(2014) Zvi Ioav Cabantchik   Frontiers in Pharmacology

Thymus and aging: morphological, radiological, and functional overview

(2013) Rita Rezzani et al.   AGE

Effect of oxygen free radicals and nitric oxide on apoptosis of immune organ induced by selenium deficiency in chickens

(2013) Zi-wei Zhang et al.   BIOMETALS

Immunomodulatory role of Emblica officinalis in arsenic induced oxidative damage and apoptosis in thymocytes of mice

(2013) Manish K Singh et al.   BMC Complementary and Alternative Medicine

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Reactive oxygen species and the free radical theory of aging

(2013) Stefan I. Liochev   FREE RADICAL BIOLOGY AND MEDICINE

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance

(2013) Martin Aichinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

The Effect of Age on Thymic Function

(2013) Donald B. Palmer   Frontiers in Immunology

Lipofuscin: formation, effects and role of macroautophagy

(2013) Annika Höhn et al.   Redox Biology

Autophagy and ageing: Insights from invertebrate model organisms

(2012) Eirini Lionaki et al.   AGEING RESEARCH REVIEWS

Immunohistological analysis of cell cycle and apoptosis regulators in thymus

(2012) Maria Bai et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Effects of Oxidative Stress on Immunosuppression Induced by Selenium Deficiency in Chickens

(2012) Zi-wei Zhang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

The Tumor Suppressor Gene ARF as a Sensor of Oxidative Stress

(2012) M. Liontos et al.   CURRENT MOLECULAR MEDICINE

Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative stress induced by cyclophosphamide in mice

(2012) Xiaojie Wei et al.   FITOTERAPIA

Oxidative stress adaptation with acute, chronic, and repeated stress

(2012) Andrew M. Pickering et al.   FREE RADICAL BIOLOGY AND MEDICINE

Minimizing the damage: repair pathways keep mitochondrial DNA intact

(2012) Lawrence Kazak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations

(2012) Conor Lawless et al.   PLoS One

Changes in primary lymphoid organs with aging

(2012) Ivan K. Chinn et al.   SEMINARS IN IMMUNOLOGY

Autophagic activity in thymus and liver during aging

(2011) Mohammad Nizam Uddin et al.   AGE

Persistent degenerative changes in thymic organ function revealed by an inducible model of organ regrowth

(2011) Ann V. Griffith et al.   AGING CELL

Mitochondrial longevity pathways

(2011) M.H. Vendelbo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

(2011) Hyun Tae Kang et al.   PLoS One

Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance

(2011) Ludger Klein et al.   TRENDS IN IMMUNOLOGY

Potential role of immunosenescence in cancer development

(2010) Tamas Fulop et al.   Annals of the New York Academy of Sciences

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Aging and Immune Function: Molecular Mechanisms to Interventions

(2010) Subramaniam Ponnappan et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial longevity pathways

(2010) Anna Raffaello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Life and death in the thymus—cell death signaling during T cell development

(2010) Jeniffer B Hernandez et al.   CURRENT OPINION IN CELL BIOLOGY

Oncogene-induced senescence: the bright and dark side of the response

(2010) Vassilis G Gorgoulis et al.   CURRENT OPINION IN CELL BIOLOGY

Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways

(2010) Dennis D Taub et al.   CURRENT OPINION IN PHARMACOLOGY

Lipofuscin-bound iron is a major intracellular source of oxidants: Role in senescent cells

(2010) Annika Höhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of Naive T Cells and Repertoire Constriction Predict Poor Response to Vaccination in Old Primates

(2010) L. Cicin-Sain et al.   JOURNAL OF IMMUNOLOGY

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Modulation of the E2F1-Driven Cancer Cell Fate by the DNA Damage Response Machinery and Potential Novel E2F1 Targets in Osteosarcomas

(2009) Michalis Liontos et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential expression of LAMPs and ubiquitin in human thymus

(2009) VICTORIA S. SARAFIAN et al.   APMIS

Smaller organ mass with greater age, except for heart

(2009) Qing He et al.   JOURNAL OF APPLIED PHYSIOLOGY

Thymic involution and immune reconstitution

(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY

An evolutionary perspective on the mechanisms of immunosenescence

(2009) Daryl P. Shanley et al.   TRENDS IN IMMUNOLOGY

Architectural changes in the thymus of aging mice

(2008) Danielle Aw et al.   AGING CELL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

(2008) Dimitrios Galaris et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Histochemical and molecular overview of the thymus as site for T-cells development

(2008) Rita Rezzani et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE