Mitochondrial responsibility in ageing process: innocent, suspect or guilty

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Mitochondrial ROS production correlates with, but does not directly regulate lifespan in drosophila

(2016) Alberto Sanz et al.   Aging-US

Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence

(2016) Martin Weinberger et al.   Aging-US

The sirtuins, oxidative stress and aging: an emerging link

(2016) Philip I. Merksamer et al.   Aging-US

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans

(2015) Yaguang Ren et al.   EXPERIMENTAL GERONTOLOGY

Epigenetic linkage of aging, cancer and nutrition

(2015) M. Daniel et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Stem cells: Asymmetric rejuvenation

(2015) Anu Suomalainen   NATURE

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

(2015) P. Katajisto et al.   SCIENCE

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

(2014) Dorian V. Ziegler et al.   AGING CELL

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Mitochondrial function and mitochondrial DNA maintenance with advancing age

(2014) Azhub I. Gaziev et al.   BIOGERONTOLOGY

Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity

(2014) Rommel A. Mathias et al.   CELL

The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans

(2014) Callista Yee et al.   CELL

Genetics and epigenetics of aging and longevity

(2014) Alexey Moskalev et al.   CELL CYCLE

Stem cells and the impact of ROS signaling

(2014) C. L. Bigarella et al.   DEVELOPMENT

The interplay between mitochondria and autophagy and its role in the aging process

(2014) Alfonso Schiavi et al.   EXPERIMENTAL GERONTOLOGY

The paradox of mitochondrial dysfunction and extended longevity

(2014) Erin Munkácsy et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats

(2014) Husam Khraiwesh et al.   EXPERIMENTAL GERONTOLOGY

SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism

(2014) Marcin Buler et al.   FASEB JOURNAL

Age-Dependent Effect of Every-Other-Day Feeding and Aerobic Exercise in Ubiquinone Levels and Related Antioxidant Activities in Mice Muscle

(2014) Elizabeth Rodríguez-Bies et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Relationship between Muscle Fiber Type-Specific PGC-1α Content and Mitochondrial Content Varies between Rodent Models and Humans

(2014) Gilles Gouspillou et al.   PLoS One

Mitochondrial pathology: stress signals from the energy factory

(2014) Nuno Raimundo   TRENDS IN MOLECULAR MEDICINE

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

Rewiring AMPK and Mitochondrial Retrograde Signaling for Metabolic Control of Aging and Histone Acetylation in Respiratory-Defective Cells

(2014) R. Magnus N. Friis et al.   Cell Reports

Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response

(2014) Vyacheslav M. Labunskyy et al.   PLoS Genetics

SIRT6, a protein with many faces

(2013) Asaf A. Gertler et al.   BIOGERONTOLOGY

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of mitochondrial DNA mutations and free radicals in disease and ageing

(2013) M. Lagouge et al.   JOURNAL OF INTERNAL MEDICINE

Alterations of Ultrastructural and Fission/Fusion Markers in Hepatocyte Mitochondria From Mice Following Calorie Restriction With Different Dietary Fats

(2013) H. Khraiwesh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

(2013) Sadhana A. Samant et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Lifespan by the Mitochondrial Electron Transport Chain: Reactive Oxygen Species-Dependent and Reactive Oxygen Species-Independent Mechanisms

(2012) Filippo Scialo et al.   ANTIOXIDANTS & REDOX SIGNALING

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

Haploinsufficiency ofCOQ4causes coenzyme Q10deficiency

(2012) Leonardo Salviati et al.   JOURNAL OF MEDICAL GENETICS

The Influence of Dietary Lipid Composition on Skeletal Muscle Mitochondria From Mice Following 1 Month of Calorie Restriction

(2012) Yana Chen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition

(2012) Jiyeong Gal et al.   NEUROCHEMISTRY INTERNATIONAL

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limited role of Sirt1 in cancer protection by dietary restriction

(2011) Daniel Herranz et al.   CELL CYCLE

Coenzyme Q deficiency in muscle

(2011) Eva Trevisson et al.   CURRENT OPINION IN NEUROLOGY

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

(2011) Filipe Cabreiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction

(2011) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness

(2011) Saskia F. Heeringa et al.   JOURNAL OF CLINICAL INVESTIGATION

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

A genomic screen for yeast mutants defective in mitophagy

(2010) Tomotake Kanki et al.   Autophagy

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

(2010) Agnieszka A. Kendrick et al.   BIOCHEMICAL JOURNAL

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage

(2010) Ae-Ri Ji et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Decreased Energy Metabolism Extends Life Span in Caenorhabditis elegans Without Reducing Oxidative Damage

(2010) J. M. Van Raamsdonk et al.   GENETICS

Role of autophagy in heart failure associated with aging

(2010) Guido R. Y. De Meyer et al.   HEART FAILURE REVIEWS

Mzm1 Influences a Labile Pool of Mitochondrial Zinc Important for Respiratory Function

(2010) Aaron Atkinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT6 in DNA repair, metabolism and ageing

(2010) D. B. Lombard et al.   JOURNAL OF INTERNAL MEDICINE

Mitochondrial DNA alterations and reduced mitochondrial function in aging

(2010) Sadie L. Hebert et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Is coenzyme Q a key factor in aging?

(2010) Guillermo López-Lluch et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The molecular mechanism of mitochondria autophagy in yeast

(2010) Tomotake Kanki et al.   MOLECULAR MICROBIOLOGY

Lessons on longevity from budding yeast

(2010) Matt Kaeberlein   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Can autophagy promote longevity?

(2010) Frank Madeo et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene Expression in a Drosophila Model of Mitochondrial Disease

(2010) Daniel J. M. Fernández-Ayala et al.   PLoS One

Muscle Physiology Changes Induced by Every Other Day Feeding and Endurance Exercise in Mice: Effects on Physical Performance

(2010) Elizabeth Rodríguez-Bies et al.   PLoS One

Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction

(2010) A. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary Restriction: Standing Up for Sirtuins

(2010) J. A. Baur et al.   SCIENCE

The Role of Autophagy During Development in Higher Eukaryotes

(2010) Sabrina Di Bartolomeo et al.   TRAFFIC

Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring

(2010) J. L. Slater-Jefferies et al.   Journal of Developmental Origins of Health and Disease

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Aging: Central role for autophagy and the lysosomal degradative system

(2009) Yogendra S. Rajawat et al.   AGEING RESEARCH REVIEWS

NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast

(2009) María Jiménez-Hidalgo et al.   AGING CELL

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

A landmark protein essential for mitophagy

(2009) Koji Okamoto et al.   Autophagy

Atg32 Is a tag for mitochondria degradation in yeast

(2009) Tomotake Kanki et al.   Autophagy

Coenzyme Q deficiency triggers mitochondria degradation by mitophagy

(2009) Ángeles Rodríguez-Hernández et al.   Autophagy

Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1

(2009) Tanja Heidler et al.   BIOGERONTOLOGY

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Expression of the Ciona intestinalis Alternative Oxidase (AOX) in Drosophila Complements Defects in Mitochondrial Oxidative Phosphorylation

(2009) Daniel J.M. Fernandez-Ayala et al.   Cell Metabolism

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration?

(2009) Federico Sesti et al.   TRENDS IN CELL BIOLOGY

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion

(2008) Dieter A. Kubli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

(2008) Ligia C. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Converting NADH to NAD+ by nicotinamide nucleotide transhydrogenase as a novel strategy against mitochondrial pathologies during aging

(2008) Abdullah Olgun   BIOGERONTOLOGY

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mitochondrial biogenesis and healthy aging

(2008) Guillermo López-Lluch et al.   EXPERIMENTAL GERONTOLOGY

The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast

(2008) E. Easlon et al.   GENES & DEVELOPMENT

Mitophagy in Yeast Occurs through a Selective Mechanism

(2008) Tomotake Kanki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics