Thymic Atrophy: Experimental Studies and Therapeutic Interventions

Differential susceptibility and maturation of thymocyte subsets during Salmonella Typhimurium infection: insights on the roles of glucocorticoids and Interferon-gamma

(2017) Shamik Majumdar et al.   Scientific Reports

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

(2016) Yun-Hee Youm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sepsis-Induced Thymic Atrophy Is Associated with Defects in Early Lymphopoiesis

(2016) Yaxian Kong et al.   STEM CELLS

Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats

(2016) Lidia A. Obukhova et al.   Aging-US

High dietary intake of vitamin C suppresses age-related thymic atrophy and contributes to the maintenance of immune cells in vitamin C-deficient senescence marker protein-30 knockout mice

(2015) Ryusei Uchio et al.   BRITISH JOURNAL OF NUTRITION

Adipocyte and leptin accumulation in tumor-induced thymic involution

(2015) ALEJANDRO LAMAS et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The burden of disease in older people and implications for health policy and practice

(2015) Martin J Prince et al.   LANCET

FSP1+ fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells

(2015) Lina Sun et al.   Scientific Reports

Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency

(2015) Ann V. Griffith et al.   Cell Reports

Regeneration of the aged thymus by a single transcription factor

(2014) N. Bredenkamp et al.   DEVELOPMENT

Monocyte chemoattractant protein 1 (MCP-1/CCL2) contributes to thymus atrophy in acute myeloid leukemia

(2014) Virginie Driss et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Randomized Controlled Trial of Palifermin (Recombinant Human Keratinocyte Growth Factor) for the Treatment of Inadequate CD4+ T-Lymphocyte Recovery in Patients with HIV-1 Infection on Antiretroviral Therapy

(2014) Jeffrey M. Jacobson et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Sex steroid blockade enhances thymopoiesis by modulating Notch signaling

(2014) Enrico Velardi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immune System in Children with Malnutrition—A Systematic Review

(2014) Maren Johanne Heilskov Rytter et al.   PLoS One

T cell Reconstitution in Allogeneic Haematopoietic Stem Cell Transplantation: Prognostic Significance of Plasma Interleukin-7

(2014) K. Kielsen et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Severe influenza A(H1N1)pdm09 infection induces thymic atrophy through activating innate CD8+CD44hi T cells by upregulating IFN-γ

(2014) B Liu et al.   Cell Death & Disease

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

(2013) Rita I. Azevedo et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD

(2013) S. Dertschnig et al.   BLOOD

c-Jun NH2-terminal kinase is a critical node in the death of CD4+CD8+thymocytes duringSalmonella entericaserovar Typhimurium infection

(2013) Mukta Deobagkar-Lele et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leptin attenuates lipopolysaccharide-induced apoptosis of thymocytes partially via down-regulation of cPLA2 and p38 MAPK activation

(2013) Chen Liang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

IL-7 Produced by Thymic Epithelial Cells Plays a Major Role in the Development of Thymocytes and TCR  + Intraepithelial Lymphocytes

(2013) S. Shitara et al.   JOURNAL OF IMMUNOLOGY

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation

(2012) M.-A. Perales et al.   BLOOD

Interferon-γ- and glucocorticoid-mediated pathways synergize to enhance death of CD4+ CD8+thymocytes duringSalmonella entericaserovar Typhimurium infection

(2012) Mukta Deobagkar-Lele et al.   IMMUNOLOGY

Molecular and Cellular Mechanisms of Mycobacterium avium-Induced Thymic Atrophy

(2012) M. Borges et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 and caspase-9 mediate thymocyte apoptosis in Trypanosoma cruzi acutely infected mice

(2012) D. A. Farias-de-Oliveira et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting Thymic Epithelia AR Enhances T-Cell Reconstitution and Bone Marrow Transplant Grafting Efficacy

(2012) Kuo-Pao Lai et al.   MOLECULAR ENDOCRINOLOGY

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

(2012) Graham Anderson et al.   TRENDS IN IMMUNOLOGY

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

(2012) Yun-Hee Youm et al.   Cell Reports

Interleukin-7 induces HIV type 1 R5-to-X4 switch

(2011) N. Brieu et al.   BLOOD

Insufficient recovery of thymopoiesis predicts for opportunistic infections in allogeneic hematopoietic stem cell transplant recipients

(2011) E.-J. Wils et al.   HAEMATOLOGICA

Effects of Intrabone Marrow–Bone Marrow Transplantation Plus Adult Thymus Transplantation on Survival of Mice Bearing Leukemia

(2011) Yuming Zhang et al.   STEM CELLS AND DEVELOPMENT

Combined Effects of Interleukin-7 and Stem Cell Factor Administration on Lymphopoiesis after Murine Bone Marrow Transplantation

(2010) Brile Chung et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Randomized, Controlled Clinical Trial of Zinc Supplementation to Prevent Immunological Failure in HIV‐Infected Adults

(2010) Marianna K. Baum et al.   CLINICAL INFECTIOUS DISEASES

Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis

(2010) Yongwen Chen et al.   FASEB JOURNAL

Sex Steroid Ablation Enhances Immune Reconstitution Following Cytotoxic Antineoplastic Therapy in Young Mice

(2010) G. L. Goldberg et al.   JOURNAL OF IMMUNOLOGY

IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

(2010) J. Unsinger et al.   JOURNAL OF IMMUNOLOGY

Regulation of Zap70 Expression During Thymocyte Development Enables Temporal Separation of CD4 and CD8 Repertoire Selection at Different Signaling Thresholds

(2010) M. Saini et al.   Science Signaling

Improved thymic index, density and output in HIV-infected patients following low-dose growth hormone therapy: a placebo controlled study

(2009) Birgitte R Hansen et al.   AIDS

Rejuvenation of the aging T cell compartment

(2009) Amanda M Holland et al.   CURRENT OPINION IN IMMUNOLOGY

Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution

(2009) Amanda L Gruver et al.   JOURNAL OF ENDOCRINOLOGY

Keratinocyte Growth Factor Improves Allogeneic Bone Marrow Engraftment through a CD4+Foxp3+ Regulatory T Cell-Dependent Mechanism

(2009) M. Bruinsma et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Thymic Adipogenesis by Caloric Restriction Is Coupled with Reduction in Age-Related Thymic Involution

(2009) H. Yang et al.   JOURNAL OF IMMUNOLOGY

Luteinizing Hormone-Releasing Hormone Enhances T Cell Recovery following Allogeneic Bone Marrow Transplantation

(2009) G. L. Goldberg et al.   JOURNAL OF IMMUNOLOGY

Thymic involution and immune reconstitution

(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY

Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation

(2008) R. M. Kelly et al.   BLOOD

Enhanced Immune System Regeneration in Humans Following Allogeneic or Autologous Hemopoietic Stem Cell Transplantation by Temporary Sex Steroid Blockade

(2008) J. S. Sutherland et al.   CLINICAL CANCER RESEARCH

Palifermin Mediates Immunoregulatory Effects in Addition to its Cytoprotective Effects in Mice with Acute Graft-Versus-Host Disease

(2008) Cynthia A. Ellison et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

(2008) Claude Sportès et al.   JOURNAL OF EXPERIMENTAL MEDICINE