Mitochondrial Homeostasis and Cellular Senescence

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

(2018) Sona Hubackova et al.   CELL DEATH AND DIFFERENTIATION

Integrating the DNA damage and protein stress responses during cancer development and treatment

(2018) Vassilis G Gorgoulis et al.   JOURNAL OF PATHOLOGY

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

(2018) Charles S. Dela Cruz et al.   MITOCHONDRION

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

(2018) Tianhong Su et al.   Genes

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

(2018) Serge Grazioli et al.   Frontiers in Immunology

Senescence and senotherapeutics: a new field in cancer therapy

(2018) Vassilios Myrianthopoulos et al.   PHARMACOLOGY & THERAPEUTICS

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis

(2018) Jun Araya et al.   Autophagy

5-Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy

(2018) Katarzyna Kornicka et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondria and cellular senescence: Implications for musculoskeletal ageing

(2018) Leena Habiballa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation

(2017) Audrey Lafargue et al.   FREE RADICAL BIOLOGY AND MEDICINE

DNA polymerases in the mitochondria A critical review of the evidence

(2017) William C Copeland   Frontiers in Bioscience-Landmark

Proteome Stability as a Key Factor of Genome Integrity

(2017) Sentiljana Gumeni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Principal Aspects Regarding the Maintenance of Mammalian Mitochondrial Genome Integrity

(2017) Panagiotis Vasileiou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA Polymerase Beta Participates in Mitochondrial DNA Repair

(2017) P. Sykora et al.   MOLECULAR AND CELLULAR BIOLOGY

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Fueling the Cell Division Cycle

(2017) María Salazar-Roa et al.   TRENDS IN CELL BIOLOGY

Mitochondrial Sirtuins and Molecular Mechanisms of Aging

(2017) Robert A.H. van de Ven et al.   TRENDS IN MOLECULAR MEDICINE

Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4

(2017) Josefina Castex et al.   Cell Death & Disease

Senoptosis: non-lethal DNA cleavage as a route to deep senescence

(2017) Maja Studencka et al.   Oncotarget

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

Robust, universal biomarker assay to detect senescent cells in biological specimens

(2016) Konstantinos Evangelou et al.   AGING CELL

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β

(2016) Eleni Liakou et al.   Aging-US

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

Molecular and biological hallmarks of ageing

(2016) J. R. Aunan et al.   BRITISH JOURNAL OF SURGERY

Fanconi Anemia Proteins Function in Mitophagy and Immunity

(2016) Rhea Sumpter et al.   CELL

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

(2016) Kaori Kobayashi et al.   CELL CYCLE

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Apoptosis or senescence? Which exit route do epithelial cells and fibroblasts preferentially follow?

(2016) Eleni Georgakopoulou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

(2016) Satish Kumar Tadi et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondria-Targeted Doxorubicin: A New Therapeutic Strategy against Doxorubicin-Resistant Osteosarcoma

(2016) I. Buondonno et al.   MOLECULAR CANCER THERAPEUTICS

Metabolism and the UPR mt

(2016) Yi-Fan Lin et al.   MOLECULAR CELL

The m -AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

(2016) Tim König et al.   MOLECULAR CELL

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

(2016) Panagiotis Galanos et al.   NATURE CELL BIOLOGY

Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease

(2016) Sentiljana Gumeni et al.   Oxidative Medicine and Cellular Longevity

Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria

(2016) Gokhan Akman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Mitochondria: Are they causal players in cellular senescence?

(2015) Clara Correia-Melo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Biogenesis: Cell-Cycle-Dependent Investment in Making Mitochondria

(2015) Takuya Shiota et al.   CURRENT BIOLOGY

Mitochondrial division and fusion in metabolism

(2015) Madhuparna Roy et al.   CURRENT OPINION IN CELL BIOLOGY

Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease

(2015) Tanveer Ahmad et al.   FASEB JOURNAL

Interaction of human mitochondrial transcription factor A in mitochondria: its involvement in the dynamics of mitochondrial DNA nucleoids

(2015) Katsumi Kasashima et al.   GENES TO CELLS

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

(2015) Gabriel Ichim et al.   MOLECULAR CELL

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

(2015) Hongshan Chen et al.   MOLECULAR CELL

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure

(2015) Joachim M. Gerhold et al.   Scientific Reports

Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells

(2015) Giulia Guzzo et al.   Oncotarget

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

(2014) Dorian V. Ziegler et al.   AGING CELL

Physiological and pathological consequences of cellular senescence

(2014) Dominick G. A. Burton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

(2014) D. A. Patten et al.   EMBO JOURNAL

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

PKCδ phosphorylation is an upstream event of GSK3 inactivation-mediated ROS generation in TGF-β1-induced senescence

(2014) H.-O. Byun et al.   FREE RADICAL RESEARCH

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions

(2014) Piero Dalle Pezze et al.   PLoS Computational Biology

Molecular chaperones and proteostasis regulation during redox imbalance

(2014) Katerina Niforou et al.   Redox Biology

SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3–FOXO1 signaling pathway

(2013) Bin Zhang et al.   AGE

Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence

(2013) Hiromichi Hara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Activation and Degradation of Mitofusins: Two Pathways Regulate Mitochondrial Fusion by Reversible Ubiquitylation

(2013) Nils Wiedemann et al.   MOLECULAR CELL

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

(2013) S. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence

(2013) Raffaele Ieva et al.   Nature Communications

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

(2012) Sören Mai et al.   Autophagy

Proteolytic control of mitochondrial function and morphogenesis

(2012) Ruchika Anand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cytosolic malate dehydrogenase regulates senescence in human fibroblasts

(2012) Seung-Min Lee et al.   BIOGERONTOLOGY

GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) β1-induced senescence

(2012) Hae-Ok Byun et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial Protein Synthesis, Import, and Assembly

(2012) Thomas D. Fox   GENETICS

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Matrix proteases in mitochondrial DNA function

(2011) Yuichi Matsushima et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Parkin Ubiquitinates Drp1 for Proteasome-dependent Degradation

(2011) Hongxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization

(2011) F.-Nora Vögtle et al.   MOLECULAR BIOLOGY OF THE CELL

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Mitochondrial protein quality control during biogenesis and aging

(2011) Brooke M. Baker et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of the Ubiquitin Conjugation System in the Maintenance of Mitochondrial Homeostasis

(2010) Albert Neutzner et al.   Annals of the New York Academy of Sciences

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

Coordination of mitochondrial bioenergetics with G1phase cell cycle progression

(2010) Stefan M. Schieke et al.   CELL CYCLE

Sirtuin Family: A Link to Metabolic Signaling and Senescence

(2010) S. Kyrylenko et al.   CURRENT MEDICINAL CHEMISTRY

Oncogene-induced senescence: the bright and dark side of the response

(2010) Vassilis G Gorgoulis et al.   CURRENT OPINION IN CELL BIOLOGY

DNA repair in mammalian mitochondria: Much more than we thought?

(2010) Pingfang Liu et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Degradation of an intramitochondrial protein by the cytosolic proteasome

(2010) V. Azzu et al.   JOURNAL OF CELL SCIENCE

Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

(2010) Y.-Y. Park et al.   JOURNAL OF CELL SCIENCE

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1

(2010) Sören Mai et al.   JOURNAL OF CELL SCIENCE

Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging

(2010) York Kamenisch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential regulation of full-length genome and a single-stranded 7S DNA along the cell cycle in human mitochondria

(2010) Anita Antes et al.   NUCLEIC ACIDS RESEARCH

Unique features of animal mitochondrial translation systems

(2010) Kimitsuna WATANABE   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Mitochondrial DNA mutations and human disease

(2009) Helen A.L. Tuppen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

(2009) Joshua R. Veatch et al.   CELL

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

(2009) Nadja C. de Souza-Pinto et al.   DNA REPAIR

Protein Quality Control in Mitochondria

(2009) T. Tatsuta   JOURNAL OF BIOCHEMISTRY

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells

(2009) M. Di Re et al.   NUCLEIC ACIDS RESEARCH

Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

(2009) S. R. Bacman et al.   NUCLEIC ACIDS RESEARCH

A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

(2009) K. Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Maturation of Iron-Sulfur Proteins in Eukaryotes: Mechanisms, Connected Processes, and Diseases

(2008) Roland Lill et al.   Annual Review of Biochemistry

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

Long Patch Base Excision Repair in Mammalian Mitochondrial Genomes

(2008) Bartosz Szczesny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Protein Quality Control by the Proteasome Involves Ubiquitination and the Protease Omi

(2008) Susanne Radke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

(2008) S. Ahmed et al.   JOURNAL OF CELL SCIENCE

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE