Pathogenesis of acute graft-versus-host disease: from intestinal microbiota alterations to donor T cell activation

Topical Ruxolitinib Protects LGR5+ Stem Cells in the Hair Follicle and Ameliorates Skin Graft-Versus-Host Disease

(2016) Shuichiro Takahashi et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

No Evidence of Impact of Maraviroc on Outcome after Allogeneic Hematopoietic Stem Cell Transplant with Reduced Intensity Conditioning (RIC)

(2016) William Adam Hammond et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Atorvastatin for the Prophylaxis of Acute Graft-versus-Host Disease in Patients Undergoing HLA-Matched Related Donor Allogeneic Hematopoietic Stem Cell Transplantation (allo-HCT)

(2016) Yvonne A. Efebera et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

(2016) R. Flynn et al.   BLOOD

Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

(2016) A. Schonle et al.   BLOOD

Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD

(2016) B. M. Matta et al.   BLOOD

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

(2016) David Michonneau et al.   IMMUNITY

Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation

(2016) Hung D. Nguyen et al.   JOURNAL OF CLINICAL INVESTIGATION

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Ipilimumab for Patients with Relapse after Allogeneic Transplantation

(2016) Matthew S. Davids et al.   NEW ENGLAND JOURNAL OF MEDICINE

miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence

(2016) Sadaf Atarod et al.   Frontiers in Immunology

Interleukin-22: Immunobiology and Pathology

(2015) Jarrod A. Dudakov et al.   Annual Review of Immunology

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

(2015) R. Flynn et al.   BLOOD

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

(2015) D. K. Reichenbach et al.   BLOOD

MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice

(2015) Y. Wu et al.   BLOOD

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

(2015) R. G. Veenstra et al.   BLOOD

MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation

(2015) S. Chen et al.   BLOOD

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

(2015) C. G. Brunstein et al.   BLOOD

Improved immune recovery after transplantation of TCRαβ/CD19-depleted allografts from haploidentical donors in pediatric patients

(2015) P Lang et al.   BONE MARROW TRANSPLANTATION

Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects

(2015) C. Carniti et al.   CLINICAL CANCER RESEARCH

Retinoic Acid Is Essential for Th1 Cell Lineage Stability and Prevents Transition to a Th17 Cell Program

(2015) Chrysothemis C. Brown et al.   IMMUNITY

Mature T cell responses are controlled by microRNA-142

(2015) Yaping Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Donor colonic CD103+dendritic cells determine the severity of acute graft-versus-host disease

(2015) Motoko Koyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanistic Assessment of PD-1H Coinhibitory Receptor–Induced T Cell Tolerance to Allogeneic Antigens

(2015) Dallas B. Flies et al.   JOURNAL OF IMMUNOLOGY

A Novel Function for P2Y2 in Myeloid Recipient–Derived Cells during Graft-versus-Host Disease

(2015) Verena Klämbt et al.   JOURNAL OF IMMUNOLOGY

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

LRRK2 and Nod2 promote lysozyme sorting in Paneth cells

(2015) Juliana D B Rocha et al.   NATURE IMMUNOLOGY

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

(2015) Stephen M. Ansell et al.   NEW ENGLAND JOURNAL OF MEDICINE

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

(2015) Jilu Zhang et al.   Science Translational Medicine

Metagenomic Analysis of the Stool Microbiome in Patients Receiving Allogeneic Stem Cell Transplantation: Loss of Diversity Is Associated with Use of Systemic Antibiotics and More Pronounced in Gastrointestinal Graft-versus-Host Disease

(2014) Ernst Holler et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Donor CD4+ Foxp3+ regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice

(2014) S. Ganguly et al.   BLOOD

MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GVHD

(2014) N. Stickel et al.   BLOOD

Therapeutic activity of multiple common  -chain cytokine inhibition in acute and chronic GVHD

(2014) A.-K. Hechinger et al.   BLOOD

The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation

(2014) Y. Taur et al.   BLOOD

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

(2014) M. F. Martelli et al.   BLOOD

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

(2014) S. Spoerl et al.   BLOOD

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Serum microRNA155 is increased in patients with acute graft-versus-host disease

(2014) Lin-Na Xie et al.   CLINICAL TRANSPLANTATION

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

Multi-Institutional Study of Post-Transplantation Cyclophosphamide As Single-Agent Graft-Versus-Host Disease Prophylaxis After Allogeneic Bone Marrow Transplantation Using Myeloablative Busulfan and Fludarabine Conditioning

(2014) Christopher G. Kanakry et al.   JOURNAL OF CLINICAL ONCOLOGY

The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation

(2014) W. Chen et al.   JOURNAL OF IMMUNOLOGY

Interleukin-22 Aggravates Murine Acute Graft-Versus-Host Disease by Expanding Effector T Cell and Reducing Regulatory T Cell

(2014) Kai Zhao et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial

(2014) Glen A Kennedy et al.   LANCET ONCOLOGY

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

(2014) Lukas Schwab et al.   NATURE MEDICINE

Role of Lymphocyte Activation Gene-3 (Lag-3) in Conventional and Regulatory T Cell Function in Allogeneic Transplantation

(2014) Emanuela I. Sega et al.   PLoS One

In Vivo T Cell Costimulation Blockade with Abatacept for Acute Graft-versus-Host Disease Prevention: A First-in-Disease Trial

(2013) Divya T. Koura et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Inflammatory neovascularization during graft-versus-host disease is regulated by  v integrin and miR-100

(2013) F. Leonhardt et al.   BLOOD

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

(2013) A. Saha et al.   BLOOD

Effector T cells require fatty acid metabolism during murine graft-versus-host disease

(2013) C. A. Byersdorfer et al.   BLOOD

Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration

(2013) K. Aoyama et al.   BLOOD

Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease

(2013) B. Xiao et al.   BLOOD

Sibling Donor and Recipient Immune Modulation With Atorvastatin for the Prophylaxis of Acute Graft-Versus-Host Disease

(2013) Mehdi Hamadani et al.   JOURNAL OF CLINICAL ONCOLOGY

The Nlrp3 inflammasome regulates acute graft-versus-host disease

(2013) Dragana Jankovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

FTY720 Markedly Increases Alloengraftment but Does Not Eliminate Host Anti-Donor T Cells that Cause Graft Rejection on Its Withdrawal

(2012) Patricia A. Taylor et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

First- and Second-Line Systemic Treatment of Acute Graft-versus-Host Disease: Recommendations of the American Society of Blood and Marrow Transplantation

(2012) Paul J. Martin et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells

(2012) R. G. Veenstra et al.   BLOOD

Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of  -defensins

(2012) Y. Eriguchi et al.   BLOOD

Regulation of acute graft-versus-host disease by microRNA-155

(2012) P. Ranganathan et al.   BLOOD

Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cells

(2012) A.-K. Hechinger et al.   HAEMATOLOGICA

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

Bortezomib-Based Graft-Versus-Host Disease Prophylaxis in HLA-Mismatched Unrelated Donor Transplantation

(2012) John Koreth et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation

(2012) Robert R. Jenq et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Profound Depletion of Host Conventional Dendritic Cells, Plasmacytoid Dendritic Cells, and B Cells Does Not Prevent Graft-versus-Host Disease Induction

(2012) H. Li et al.   JOURNAL OF IMMUNOLOGY

Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease

(2012) Ran Reshef et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDO in Human Gut Graft-versus-Host Disease

(2011) Philippe Ratajczak et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

(2011) K. L. Hippen et al.   BLOOD

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL

(2011) A. M. Hanash et al.   BLOOD

Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cells

(2011) T. Toubai et al.   BLOOD

Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway

(2011) Y. Sakoda et al.   BLOOD

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+T cells

(2011) Qianting Yang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vstm3 is a member of the CD28 family and an important modulator of T-cell function

(2011) Steven D. Levin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells

(2011) Leona Gabryšová et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

(2011) Daigo Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells

(2011) Shuichiro Takashima et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Silencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis

(2011) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease

(2011) Motoko Koyama et al.   NATURE MEDICINE

Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells

(2011) Tatiana N. Golovina et al.   PLoS One

PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells

(2010) W. Koestner et al.   BLOOD

Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses

(2010) R. Das et al.   BLOOD

SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage

(2010) M. Giroux et al.   BLOOD

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13

(2010) S. L. Highfill et al.   BLOOD

Interleukin-2 receptor downstream events in regulatory T cells: Implications for the choice of immunosuppressive drug therapy

(2010) Robert Zeiser et al.   CELL CYCLE

Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow Transplantation

(2010) I. Tawara et al.   CLINICAL CANCER RESEARCH

Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice

(2010) Shoji Asakura et al.   JOURNAL OF CLINICAL INVESTIGATION

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

(2010) Rachel A. Gottschalk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells

(2009) M. Koyama et al.   BLOOD

Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality

(2009) L. K. Jasperson et al.   BLOOD

IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

(2009) C. Bucher et al.   BLOOD

Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation

(2009) M. Rotta et al.   BLOOD

Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors

(2009) O. Penack et al.   BLOOD

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease

(2009) X. Chen et al.   BLOOD

Addition of Infliximab to Standard Acute Graft-versus-Host Disease Prophylaxis following Allogeneic Peripheral Blood Cell Transplantation

(2008) Mehdi Hamadani et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation

(2008) A. Bashey et al.   BLOOD

STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease

(2008) S. X. Lu et al.   BLOOD

Control of protein synthesis and mRNA degradation by microRNAs

(2008) Jidong Liu   CURRENT OPINION IN CELL BIOLOGY

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

(2008) Xin Yu et al.   NATURE IMMUNOLOGY

Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality

(2007) L. K. Jasperson et al.   BLOOD