PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells

The Host Environment Regulates the Function of CD8+ Graft-versus-Host-Reactive Effector Cells

(2014) R. Chakraverty et al.   JOURNAL OF IMMUNOLOGY

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

(2010) Q. Zhou et al.   BLOOD

Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice

(2010) Shoji Asakura et al.   JOURNAL OF CLINICAL INVESTIGATION

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

(2010) Gavin M Bendle et al.   NATURE MEDICINE

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

(2009) Q. Zhou et al.   BLOOD

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft-versus-leukemia effects across MHC barriers in full chimeras

(2009) A. Ghosh et al.   BLOOD

PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

(2009) L. Zhang et al.   BLOOD

Kinetic Preservation of Dual Specificity of Coprogrammed Minor Histocompatibility Antigen-Reactive Virus-Specific T Cells

(2009) M. M. van Loenen et al.   CANCER RESEARCH

Preclinical development of T cell receptor gene therapy

(2009) Gavin M Bendle et al.   CURRENT OPINION IN IMMUNOLOGY

Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity

(2009) P D Peng et al.   GENE THERAPY

Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I–II study

(2009) Fabio Ciceri et al.   LANCET ONCOLOGY

Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation

(2009) Luca Vago et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

(2008) F. Haspot et al.   BLOOD

A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation

(2008) F. Ciceri et al.   BLOOD

Adoptive Cell Therapy for Patients with Melanoma, Using Tumor-Infiltrating Lymphocytes Genetically Engineered to Secrete Interleukin-2

(2008) Bianca Heemskerk et al.   HUMAN GENE THERAPY

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

(2008) Carolina Berger et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytotoxic T Cells Reactive to an Immunodominant Leukemia-associated Antigen can be Specifically Primed and Expanded by Combining a Specific Priming Step With Nonspecific Large-scale Expansion

(2008) Arnab Ghosh et al.   JOURNAL OF IMMUNOTHERAPY