Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B

(2015) Inna S. Afonina et al.   IMMUNOLOGICAL REVIEWS

Cutting Edge: IL-21 Is Not Essential for Th17 Differentiation or Experimental Autoimmune Encephalomyelitis

(2014) J. M. Coquet et al.   JOURNAL OF IMMUNOLOGY

Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease

(2011) K. L. Hippen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL

(2011) A. M. Hanash et al.   BLOOD

Thymic T-cell development in allogeneic stem cell transplantation

(2011) W. Krenger et al.   BLOOD

Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new

(2011) J. M. Coghill et al.   BLOOD

IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B

(2011) Jean Publicover et al.   JOURNAL OF CLINICAL INVESTIGATION

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells

(2010) R. Broady et al.   BLOOD

Th17/Treg ratio in human graft-versus-host disease

(2010) P. Ratajczak et al.   BLOOD

Altered Effector CD4+ T Cell Function in IL-21R-/- CD4+ T Cell-Mediated Graft-Versus-Host Disease

(2010) I. Oh et al.   JOURNAL OF IMMUNOLOGY

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

(2009) C. Bucher et al.   BLOOD

Acute graft-versus-host disease: from the bench to the bedside

(2009) G. Socie et al.   BLOOD

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

(2009) T. Yi et al.   BLOOD

IL-21 is critical for GVHD in a mouse model

(2009) A Meguro et al.   BONE MARROW TRANSPLANTATION

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

(2008) K. L. Hippen et al.   BLOOD

Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease

(2008) T. Yi et al.   BLOOD

IL-17 contributes to CD4-mediated graft-versus-host disease

(2008) L. W. Kappel et al.   BLOOD

In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations

(2008) M. J. Carlson et al.   BLOOD

IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunityin vivo

(2008) Ivo Sonderegger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease

(2008) Isao Tawara et al.   EXPERIMENTAL HEMATOLOGY

Interleukin 21: a cytokine/cytokine receptor system that has come of age

(2008) Warren J. Leonard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

IL-21 signaling is critical for the development of type I diabetes in the NOD mouse

(2008) R. Spolski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses

(2008) Giovanni Monteleone et al.   TRENDS IN IMMUNOLOGY

IL-21 receptor expression determines the temporal phases of experimental autoimmune encephalomyelitis

(2007) Ruolan Liu et al.   EXPERIMENTAL NEUROLOGY