The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes

(2014) Johan Larsbrink et al.   NATURE

Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes

(2013) Thaher Pelaseyed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins

(2013) Ana M. Rodríguez-Piñeiro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

(2013) Anna Ermund et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

(2013) Khushbu K Patel et al.   EMBO JOURNAL

Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective device

(2013) Thaher Pelaseyed et al.   FEBS Journal

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

The Mucin Muc2 Limits Pathogen Burdens and Epithelial Barrier Dysfunction during Salmonella enterica Serovar Typhimurium Colitis

(2013) Maryam Zarepour et al.   INFECTION AND IMMUNITY

Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia coli

(2013) George M. H. Birchenough et al.   INFECTION AND IMMUNITY

Site-specificO-Glycosylation on the MUC2 Mucin Protein Inhibits Cleavage by thePorphyromonas gingivalisSecreted Cysteine Protease (RgpB)

(2013) Sjoerd van der Post et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-talk between intraepithelial γδ T cells and epithelial cells

(2013) Deborah A. Witherden et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulatory T cells in nonlymphoid tissues

(2013) Dalia Burzyn et al.   NATURE IMMUNOLOGY

Commensal bacteria at the interface of host metabolism and the immune system

(2013) Jonathan R Brestoff et al.   NATURE IMMUNOLOGY

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

(2013) Abdessamad El Kaoutari et al.   NATURE REVIEWS MICROBIOLOGY

Dynamic Changes in Mucus Thickness and Ion Secretion during Citrobacter rodentium Infection and Clearance

(2013) Jenny K. Gustafsson et al.   PLoS One

Mucus Properties and Goblet Cell Quantification in Mouse, Rat and Human Ileal Peyer's Patches

(2013) Anna Ermund et al.   PLoS One

Negative feedback by IRE1  optimizes mucin production in goblet cells

(2013) A. Tsuru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Lamellar Structures of MUC2-Rich Mucin: A Potential Role in Governing the Barrier and Lubricating Functions of Intestinal Mucus

(2012) Andrew N. Round et al.   BIOMACROMOLECULES

Ischaemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon

(2012) Joep Grootjans et al.   GUT

The goblet cell: a key player in ischaemia-reperfusion injury

(2012) Malin E V Johansson et al.   GUT

Sensing of microbial molecular patterns by Toll-like receptors

(2012) Dong Hyun Song et al.   IMMUNOLOGICAL REVIEWS

Self-cleavage of Human CLCA1 Protein by a Novel Internal Metalloprotease Domain Controls Calcium-activated Chloride Channel Activation

(2012) Zeynep Yurtsever et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

(2012) Jenny K. Gustafsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity

(2012) Koutaro Ishibashi et al.   MOLECULAR BIOLOGY OF THE CELL

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli

(2012) Y H Sheng et al.   Mucosal Immunology

The ER stress transducer IRE1β is required for airway epithelial mucin production

(2012) M B Martino et al.   Mucosal Immunology

Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways

(2012) M Kesimer et al.   Mucosal Immunology

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins

(2012) Malin E. V. Johansson   PLoS One

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

(2012) D. Ambort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis

(2011) Steven J. McElroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

(2011) E. P. Bennett et al.   GLYCOBIOLOGY

The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis

(2011) Y. H. Sheng et al.   GUT

Role of Pro-oncogenic Protein Disulfide Isomerase (PDI) Family Member Anterior Gradient 2 (AGR2) in the Control of Endoplasmic Reticulum Homeostasis

(2011) Arisa Higa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AGR2Gene Function Requires a Unique Endoplasmic Reticulum Localization Motif

(2011) Aparna Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

(2011) François Gerbe et al.   JOURNAL OF CELL BIOLOGY

CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein GOPC

(2011) T. Pelaseyed et al.   JOURNAL OF CELL SCIENCE

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

(2011) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcytosis ofListeria monocytogenesacross the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin

(2011) Georgios Nikitas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes

(2011) A. Bas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Keeping Bacteria at a Distance

(2011) M. E. V. Johansson et al.   SCIENCE

Butyrophilins: an emerging family of immune regulators

(2011) Lucie Abeler-Dörner et al.   TRENDS IN IMMUNOLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Paneth cells and innate mucosal immunity

(2010) André J Ouellette   CURRENT OPINION IN GASTROENTEROLOGY

Epithelial decision makers: in search of the 'epimmunome'

(2010) Mahima Swamy et al.   NATURE IMMUNOLOGY

The future of mucosal immunology: studying an integrated system-wide organ

(2010) Navkiran Gill et al.   NATURE IMMUNOLOGY

Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

(2010) Malin E. V. Johansson et al.   PLoS One

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

(2010) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

(2010) Kirk S. B. Bergstrom et al.   PLoS Pathogens

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice

(2009) Fang Zhao et al.   DEVELOPMENTAL BIOLOGY

Association of Cell Surface Mucins with Galectin-3 Contributes to the Ocular Surface Epithelial Barrier

(2009) Pablo Argüeso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early endosomes and endosomal coatomer are required for autophagy

(2009) Minoo Razi et al.   JOURNAL OF CELL BIOLOGY

Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein

(2009) Malin E. V. Johansson et al.   JOURNAL OF PROTEOME RESEARCH

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

(2009) S.-W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MUC1 Limits Helicobacter pylori Infection both by Steric Hindrance and by Acting as a Releasable Decoy

(2009) Sara K. Lindén et al.   PLoS Pathogens

The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine

(2008) Emily K. Malmberg et al.   BIOCHEMICAL JOURNAL

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Small intestinal CD103+dendritic cells display unique functional properties that are conserved between mice and humans

(2008) Elin Jaensson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants

(2008) Q. V. Tu et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Mucins in the mucosal barrier to infection

(2008) S K Linden et al.   Mucosal Immunology

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE

Structure and Function of the Cell Surface (Tethered) Mucins

(2007) Christine L. Hattrup et al.   Annual Review of Physiology