Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

(2012) E. F. Tewalt et al.   BLOOD

Loss of B7-H1 Expression by Recipient Parenchymal Cells Leads to Expansion of Infiltrating Donor CD8+ T Cells and Persistence of Graft-Versus-Host Disease

(2011) X. Li et al.   JOURNAL OF IMMUNOLOGY

The PDL1-PD1 Axis Converts Human TH1 Cells into Regulatory T Cells

(2011) S. Amarnath et al.   Science Translational Medicine

PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells

(2010) W. Koestner et al.   BLOOD

Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice

(2010) Shoji Asakura et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation

(2010) Barry Flutter et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute graft-versus-host disease: from the bench to the bedside

(2009) G. Socie et al.   BLOOD

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

(2009) T. Yi et al.   BLOOD

PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

(2009) Debora Franceschini et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis

(2009) Chunhe Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

(2009) K. Brandl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

(2008) Nancie J. MacIver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA