LRRK2 and Nod2 promote lysozyme sorting in Paneth cells

An early endosome regulator, Rab5b, is an LRRK2 kinase substrate

(2015) Hye Jin Yun et al.   JOURNAL OF BIOCHEMISTRY

Commensal bacteria direct selective cargo sorting to promote symbiosis

(2015) Qin Zhang et al.   NATURE IMMUNOLOGY

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

(2014) Henner F. Farin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paneth Cells: Maestros of the Small Intestinal Crypts

(2013) Hans C. Clevers et al.   Annual Review of Physiology

Antimicrobial peptides and gut microbiota in homeostasis and pathology

(2013) Maureen J. Ostaff et al.   EMBO Molecular Medicine

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease: Figure 1

(2012) Patrick A. Lewis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation inCaenorhabditis elegans

(2009) Marija Sumakovic et al.   JOURNAL OF CELL BIOLOGY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE