Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 2, Pages 675
Publisher
MDPI AG
Online
2020-01-21
DOI
10.3390/ijms21020675
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Claudin-3-deficient C57BL/6J mice display intact brain barriers
- (2019) Mariana Castro Dias et al. Scientific Reports
- Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease
- (2019) Robert Shenkar et al. STROKE
- Familial Cerebral Cavernous Malformations
- (2019) Atif Zafar et al. STROKE
- CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression
- (2019) Marco Castro et al. CIRCULATION RESEARCH
- Cavernous angiomas: deconstructing a neurosurgical disease
- (2019) Issam A. Awad et al. JOURNAL OF NEUROSURGERY
- A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis
- (2019) Eric M. Chapman et al. Nature Communications
- Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity
- (2019) Tetsuhisa Otani et al. JOURNAL OF CELL BIOLOGY
- Coxsackievirus and adenovirus receptor mediates the responses of endothelial cells to fluid shear stress
- (2019) Jihwa Chung et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation
- (2019) Alan T. Tang et al. Science Translational Medicine
- Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure
- (2018) Allison M. Johnson et al. FASEB JOURNAL
- The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation
- (2018) Yitang Wang et al. FASEB JOURNAL
- The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs
- (2018) Narendra Suryavanshi et al. BMC CELL BIOLOGY
- Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells
- (2018) Matthew R. Detter et al. CIRCULATION RESEARCH
- Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial
- (2018) Sean P Polster et al. NEUROSURGERY
- The EPAC–Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability
- (2017) Carla J. Ramos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- β1-integrin–matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability
- (2017) Yoshikane Izawa et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations
- (2017) Miguel Alejandro Lopez-Ramirez et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations
- (2017) Romuald Girard et al. JOURNAL OF NEUROSURGERY
- Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
- (2017) Alan T. Tang et al. NATURE
- Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium
- (2017) Luca Goitre et al. Scientific Reports
- Population-Based Prevalence of Cerebral Cavernous Malformations in Older Adults
- (2017) Kelly D. Flemming et al. JAMA Neurology
- Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In VivoSignificance
- (2016) Klaudia Schossleitner et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- TAK1 knockdown enhances lipopolysaccharide-induced secretion of proinflammatory cytokines in myeloid cells via unleashing MEKK3 activity
- (2016) Kun Li et al. CELLULAR IMMUNOLOGY
- RHO binding to FAM65A regulates Golgi reorientation during cell migration
- (2016) Faraz K. Mardakheh et al. JOURNAL OF CELL SCIENCE
- Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling
- (2016) Zinan Zhou et al. NATURE
- Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation
- (2016) Huanjiao Jenny Zhou et al. NATURE MEDICINE
- Vascular endothelial growth factor: a neurovascular target in neurological diseases
- (2016) Christian Lange et al. Nature Reviews Neurology
- RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations
- (2016) Robert Shenkar et al. STROKE
- miR-613 suppresses ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting the programmed cell death 10 gene
- (2016) Zhenhua Wu et al. BioScience Trends
- Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity
- (2016) Bart-Jan de Kreuk et al. eLife
- PDCD10 (CCM3) regulates brain endothelial barrier integrity in cerebral cavernous malformation type 3: role of CCM3-ERK1/2-cortactin cross-talk
- (2015) Svetlana M. Stamatovic et al. ACTA NEUROPATHOLOGICA
- Role of Krev Interaction Trapped-1 in Prostacyclin-Induced Protection against Lung Vascular Permeability Induced by Excessive Mechanical Forces and Thrombin Receptor Activating Peptide 6
- (2015) Angelo Meliton et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression
- (2015) Zinan Zhou et al. DEVELOPMENTAL CELL
- Defective autophagy is a key feature of cerebral cavernous malformations
- (2015) Saverio Marchi et al. EMBO Molecular Medicine
- CCM2–CCM3 interaction stabilizes their protein expression and permits endothelial network formation
- (2015) Kyle M. Draheim et al. JOURNAL OF CELL BIOLOGY
- ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation
- (2015) Olga Tornavaca et al. JOURNAL OF CELL BIOLOGY
- Vascular Permeability in Cerebral Cavernous Malformations
- (2015) Abdul G Mikati et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3
- (2015) Xavier Cullere et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Blood–Brain Barrier
- (2015) Richard Daneman et al. Cold Spring Harbor Perspectives in Biology
- CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling
- (2015) Benjamin Lant et al. Nature Communications
- Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex
- (2015) Oriana S. Fisher et al. Nature Communications
- Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations
- (2014) Robert Shenkar et al. GENETICS IN MEDICINE
- Lack of CCM1 induces hypersprouting and impairs response to flow
- (2014) Tara M. Mleynek et al. HUMAN MOLECULAR GENETICS
- Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis
- (2014) David A. McDonald et al. HUMAN MOLECULAR GENETICS
- KRIT1 Protein Depletion Modifies Endothelial Cell Behavior via Increased Vascular Endothelial Growth Factor (VEGF) Signaling
- (2014) Peter V. DiStefano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma
- (2014) Dejan Jakimovski et al. JOURNAL OF NEUROSURGERY
- Long-term natural history of incidentally discovered cavernous malformations in a single-center cohort
- (2014) S. Arthur Moore et al. JOURNAL OF NEUROSURGERY
- Rho GAPs and GEFs
- (2014) Jaap D van Buul et al. Cell Adhesion & Migration
- Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling
- (2013) C. W. Wilson et al. BLOOD
- Small Rho GTPases in the control of cell shape and mobility
- (2013) Arun Murali et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis
- (2013) Martin M.N. Schmitt et al. CIRCULATION
- ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway
- (2013) Jonathan N. Rosen et al. DEVELOPMENTAL BIOLOGY
- A Network of Interactions Enables CCM3 and STK24 to Coordinate UNC13D-Driven Vesicle Exocytosis in Neutrophils
- (2013) Yong Zhang et al. DEVELOPMENTAL CELL
- Targeting endothelial junctional adhesion molecule-A/ EPAC/ Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic muscles
- (2013) Monica Giannotta et al. EMBO Molecular Medicine
- Calcium and Calmodulin-dependent Serine/Threonine Protein Kinase Type II (CaMKII)-mediated Intramolecular Opening of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP-1α) Negatively Regulates β1 Integrins
- (2013) Angélique Millon-Frémillon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail
- (2013) Alexandre R. Gingras et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CCM1–ICAP-1 complex controls β1 integrin–dependent endothelial contractility and fibronectin remodeling
- (2013) Eva Faurobert et al. JOURNAL OF CELL BIOLOGY
- Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux
- (2013) Mary M. Buschmann et al. MOLECULAR BIOLOGY OF THE CELL
- Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation
- (2013) Weizhi Liu et al. MOLECULAR CELL
- EndMT contributes to the onset and progression of cerebral cavernous malformations
- (2013) Luigi Maddaluno et al. NATURE
- Claudins and the Modulation of Tight Junction Permeability
- (2013) Dorothee Günzel et al. PHYSIOLOGICAL REVIEWS
- Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29
- (2013) A. Post et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Decreased Krev Interaction–Trapped 1 Expression Leads to Increased Vascular Permeability and Modifies Inflammatory Responses In Vivo
- (2012) Maripat Corr et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Dynamic Regulation of the Cerebral Cavernous Malformation Pathway Controls Vascular Stability and Growth
- (2012) Xiangjian Zheng et al. DEVELOPMENTAL CELL
- Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus
- (2012) Oriana S. Fisher et al. FEBS LETTERS
- PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress
- (2012) Heyu Zhang Frontiers in Bioscience-Landmark
- STK25 Protein Mediates TrkA and CCM2 Protein-dependent Death in Pediatric Tumor Cells of Neural Origin
- (2012) Barbara Costa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adaptor Protein Cerebral Cavernous Malformation 3 (CCM3) Mediates Phosphorylation of the Cytoskeletal Proteins Ezrin/Radixin/Moesin by Mammalian Ste20-4 to Protect Cells from Oxidative Stress
- (2012) Miguel Fidalgo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural basis of the junctional anchorage of the cerebral cavernous malformations complex
- (2012) Alexandre R. Gingras et al. JOURNAL OF CELL BIOLOGY
- Prospective hemorrhage risk of intracerebral cavernous malformations
- (2012) K. D. Flemming et al. NEUROLOGY
- Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3
- (2011) Johnthan Gordon et al. BMC BIOCHEMISTRY
- Blood Vessel Tubulogenesis Requires Rasip1 Regulation of GTPase Signaling
- (2011) Ke Xu et al. DEVELOPMENTAL CELL
- Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations
- (2011) Kirk Cunningham et al. HUMAN MOLECULAR GENETICS
- Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3)
- (2011) Xiaofeng Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 Homodimerization
- (2011) Derek F. Ceccarelli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice
- (2011) Aubrey C. Chan et al. JOURNAL OF CLINICAL INVESTIGATION
- Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice
- (2011) Gwénola Boulday et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Impairment of Tight Junctions and Glucose Transport in Endothelial Cells of Human Cerebral Cavernous Malformations
- (2011) Hannah Schneider et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease
- (2011) David A. McDonald et al. STROKE
- Recessive Mutations in the Gene Encoding the Tight Junction Protein Occludin Cause Band-like Calcification with Simplified Gyration and Polymicrogyria
- (2010) Mary C. O'Driscoll et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1
- (2010) Shu Ito et al. CURRENT BIOLOGY
- A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease
- (2010) D. A. McDonald et al. HUMAN MOLECULAR GENETICS
- Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity
- (2010) Xiaofeng Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
- (2010) M. Fidalgo et al. JOURNAL OF CELL SCIENCE
- CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations
- (2010) Xiangjian Zheng et al. JOURNAL OF CLINICAL INVESTIGATION
- Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
- (2010) Rebecca A. Stockton et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions
- (2010) David R. Raleigh et al. MOLECULAR BIOLOGY OF THE CELL
- Rho Signaling and Tight Junction Functions
- (2010) Steve Terry et al. PHYSIOLOGY
- KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species
- (2010) Luca Goitre et al. PLoS One
- Defining the Functional Domain of Programmed Cell Death 10 through Its Interactions with Phosphatidylinositol-3,4,5-Trisphosphate
- (2010) Christopher F. Dibble et al. PLoS One
- Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular Development
- (2010) Y. He et al. Science Signaling
- Zonula Occludens-1 and -2 Are Cytosolic Scaffolds That Regulate the Assembly of Cellular Junctions
- (2009) Alan S. Fanning et al. Annals of the New York Academy of Sciences
- Structural determinants of Junctional Adhesion Molecule A (JAM-A) function and mechanisms of intracellular signaling
- (2009) Eric A Severson et al. CURRENT OPINION IN CELL BIOLOGY
- Rap1 and its effector KRIT1/CCM1 regulate -catenin signaling
- (2009) A. J. Glading et al. Disease Models & Mechanisms
- Cerebral Cavernous Malformation 2 Protein Promotes Smad Ubiquitin Regulatory Factor 1-mediated RhoA Degradation in Endothelial Cells
- (2009) Lisa E. S. Crose et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability
- (2009) Susanne M. Krug et al. MOLECULAR BIOLOGY OF THE CELL
- The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases
- (2009) Kevin J Whitehead et al. NATURE MEDICINE
- Regulation of cardiovascular development and integrity by the heart of glass–cerebral cavernous malformation protein pathway
- (2009) Benjamin Kleaveland et al. NATURE MEDICINE
- CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase
- (2009) Liraz Harel et al. NEURON
- Apoptotic Functions of PDCD10/CCM3 , the Gene Mutated in Cerebral Cavernous Malformation 3
- (2009) Leiling Chen et al. STROKE
- Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells
- (2008) Masaru Yamamoto et al. AMERICAN JOURNAL OF PATHOLOGY
- ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish
- (2008) Benjamin M. Hogan et al. HUMAN MOLECULAR GENETICS
- Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis
- (2008) Amy L. Akers et al. HUMAN MOLECULAR GENETICS
- A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein
- (2008) Marilyn Goudreault et al. MOLECULAR & CELLULAR PROTEOMICS
- Deficiency of Zonula Occludens-1 Causes Embryonic Lethal Phenotype Associated with Defected Yolk Sac Angiogenesis and Apoptosis of Embryonic Cells
- (2008) Tatsuya Katsuno et al. MOLECULAR BIOLOGY OF THE CELL
- Hemorrhage From Cavernous Malformations of the Brain
- (2008) Rustam Al-Shahi Salman et al. STROKE
- Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis
- (2007) Yann Wallez et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now