Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29

KIF14 negatively regulates Rap1a–Radil signaling during breast cancer progression

(2012) Syed M. Ahmed et al.   JOURNAL OF CELL BIOLOGY

Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling

(2012) Stephan Huveneers et al.   JOURNAL OF CELL BIOLOGY

Nuanced junctional RhoA activity

(2012) Swapnil S. Kher et al.   NATURE CELL BIOLOGY

Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

(2012) Aparna Ratheesh et al.   NATURE CELL BIOLOGY

Rap1 Can Bypass the FAK-Src-Paxillin Cascade to Induce Cell Spreading and Focal Adhesion Formation

(2012) Sarah H. Ross et al.   PLoS One

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control

(2011) Willem-Jan Pannekoek et al.   CELLULAR SIGNALLING

Blood Vessel Tubulogenesis Requires Rasip1 Regulation of GTPase Signaling

(2011) Ke Xu et al.   DEVELOPMENTAL CELL

Ezrin is required for efficient Rap1-induced cell spreading

(2011) S. H. Ross et al.   JOURNAL OF CELL SCIENCE

Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

(2011) Stephen J. Terry et al.   NATURE CELL BIOLOGY

Adherens junctions connect stress fibers between adjacent endothelial cells

(2010) Jaime Millan et al.   BMC BIOLOGY

G Protein βγ Subunits Regulate Cell Adhesion through Rap1a and Its Effector Radil

(2010) Syed M. Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

(2010) Rebecca A. Stockton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens

(2010) Michael Smutny et al.   NATURE CELL BIOLOGY

Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation

(2009) Ke Xu et al.   DEVELOPMENTAL BIOLOGY

Rap1 and its effector KRIT1/CCM1 regulate  -catenin signaling

(2009) A. J. Glading et al.   Disease Models & Mechanisms

Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP

(2009) Anna A. Birukova et al.   MICROVASCULAR RESEARCH

Vascular Endothelial-Cadherin Stabilizes at Cell–Cell Junctions by Anchoring to Circumferential Actin Bundles through α- and β-Catenins in Cyclic AMP-Epac-Rap1 Signal-activated Endothelial Cells

(2009) Kazuomi Noda et al.   MOLECULAR BIOLOGY OF THE CELL

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics

(2008) Karen S. Lyle et al.   CELLULAR SIGNALLING

Vascular permeability in cardiovascular disease and cancer

(2008) Sara M Weis   CURRENT OPINION IN HEMATOLOGY

PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways

(2008) Magdalena J. Lorenowicz et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Epac1, an Exchange Factor for Rap GTPases, in Endothelial Microtubule Dynamics and Barrier Function

(2008) Seema Sehrawat et al.   MOLECULAR BIOLOGY OF THE CELL