Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex

The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression

(2015) Zinan Zhou et al.   DEVELOPMENTAL CELL

Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations

(2014) Oriana S. Fisher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis

(2013) Andreas Fischer et al.   TRENDS IN MOLECULAR MEDICINE

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling

(2012) Bryan T. Richardson et al.   BIOLOGICAL CHEMISTRY

Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus

(2012) Oriana S. Fisher et al.   FEBS LETTERS

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cerebral cavernous malformations: from genes to proteins to disease

(2011) Daniel D. Cavalcanti et al.   JOURNAL OF NEUROSURGERY

A mechanism of Rap1-induced stabilization of endothelial cell–cell junctions

(2011) Jian J. Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity

(2010) Xiaofeng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho Kinase Inhibition Rescues the Endothelial Cell Cerebral Cavernous Malformation Phenotype

(2010) Asya L. Borikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

(2010) Rebecca A. Stockton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations

(2009) G. Boulday et al.   Disease Models & Mechanisms

MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival

(2009) X. Wang et al.   JOURNAL OF IMMUNOLOGY

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

PDBsum new things

(2008) R. A. Laskowski   NUCLEIC ACIDS RESEARCH