Familial Cerebral Cavernous Malformations

Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional GrowthNovelty and Significance

(2018) Romuald Girard et al.   CIRCULATION RESEARCH

Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations

(2017) Miguel Alejandro Lopez-Ramirez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage

(2017) Hussein A. Zeineddine et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations

(2017) Romuald Girard et al.   JOURNAL OF NEUROSURGERY

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

(2017) Alan T. Tang et al.   NATURE

First large genomic inversion in familial cerebral cavernous malformation identified by whole genome sequencing

(2017) Stefanie Spiegler et al.   NEUROGENETICS

Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel

(2017) Amy Akers et al.   NEUROSURGERY

Familial Cerebral Cavernous Malformations Are Associated with Adrenal Calcifications on CT Scans: An Imaging Biomarker for a Hereditary Cerebrovascular Condition

(2017) Corinne D. Strickland et al.   RADIOLOGY

Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations

(2017) Romuald Girard et al.   Translational Stroke Research

Population-Based Prevalence of Cerebral Cavernous Malformations in Older Adults

(2017) Kelly D. Flemming et al.   JAMA Neurology

Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease

(2016) Romuald Girard et al.   Biomarkers in Medicine

Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data

(2016) Margaret A Horne et al.   LANCET NEUROLOGY

Erratum: Corrigendum: Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

(2016) Zinan Zhou et al.   NATURE

Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

(2016) Zinan Zhou et al.   NATURE

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations

(2016) Robert Shenkar et al.   STROKE

Prospective Hemorrhage Rates of Cerebral Cavernous Malformations in Children and Adolescents Based on MRI Appearance

(2015) O. Nikoubashman et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations

(2015) R. Cuttano et al.   EMBO Molecular Medicine

Management of Cerebral Cavernous Malformations: From Diagnosis to Treatment

(2015) Nikolaos Mouchtouris et al.   TheScientificWorldJOURNAL

Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex

(2015) Oriana S. Fisher et al.   Nature Communications

Management of Cerebral Cavernous Malformations: From Diagnosis to Treatment

(2015) Nikolaos Mouchtouris et al.   Scientific World Journal

Association of Cardiovascular Risk Factors with Disease Severity in Cerebral Cavernous Malformation Type 1 Subjects with the Common Hispanic Mutation

(2014) Hélène Choquet et al.   CEREBROVASCULAR DISEASES

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations

(2014) Robert Shenkar et al.   GENETICS IN MEDICINE

Evaluation of Iron Content in Human Cerebral Cavernous Malformation Using Quantitative Susceptibility Mapping

(2014) Huan Tan et al.   INVESTIGATIVE RADIOLOGY

Long-term natural history of incidentally discovered cavernous malformations in a single-center cohort

(2014) S. Arthur Moore et al.   JOURNAL OF NEUROSURGERY

Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology

(2013) Oriana S. Fisher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cavernoma-related epilepsy: Review and recommendations for management-Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies

(2013) Felix Rosenow et al.   EPILEPSIA

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

Dynamic Permeability and Quantitative Susceptibility

(2013) Abdul Ghani Mikati et al.   STROKE

Natural history and imaging prevalence of cavernous malformations in children and young adults

(2012) Wajd N. Al-Holou et al.   Journal of Neurosurgery-Pediatrics

Cerebral Cavernous Malformations and Pregnancy

(2012) Christopher D. Witiw et al.   NEUROSURGERY

Surgical versus conservative treatment in patients with cerebral cavernomas and non refractory epilepsy

(2012) Santiago Fernández et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Cerebral cavernous malformations: from molecular pathogenesis to genetic counselling and clinical management

(2011) Remco A Haasdijk et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The natural history of intracranial cavernous malformations

(2011) Bradley A. Gross et al.   Neurosurgical Focus

Management of incidental cavernous malformations: a review

(2011) Richard T. Dalyai et al.   Neurosurgical Focus

Validation of In Vivo Magnetic Resonance Imaging Blood–Brain Barrier Permeability Measurements by Comparison With Gold Standard Histology

(2011) Angelika Hoffmann et al.   STROKE

Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease

(2011) David A. McDonald et al.   STROKE

Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity

(2010) Xiaofeng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

(2010) Rebecca A. Stockton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantitative imaging of intrinsic magnetic tissue properties using MRI signal phase: An approach to in vivo brain iron metabolism?

(2010) Ferdinand Schweser et al.   NEUROIMAGE

Emerging clinical imaging techniques for cerebral cavernous malformations: a systematic review

(2010) Peter G. Campbell et al.   Neurosurgical Focus

Familial versus Sporadic Cavernous Malformations: Differences in Developmental Venous Anomaly Association and Lesion Phenotype

(2009) T.A. Petersen et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Cavernous malformations: natural history, diagnosis and treatment

(2009) Sachin Batra et al.   Nature Reviews Neurology