Cavernous angiomas: deconstructing a neurosurgical disease

Safety and effectiveness of stereotactic laser ablation for epileptogenic cerebral cavernous malformations

(2019) Jon T. Willie et al.   EPILEPSIA

Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease

(2019) Robert Shenkar et al.   STROKE

Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional GrowthNovelty and Significance

(2018) Romuald Girard et al.   CIRCULATION RESEARCH

Phenotypic characterization of murine models of cerebral cavernous malformations

(2018) Hussein A. Zeineddine et al.   LABORATORY INVESTIGATION

Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH)

(2018) Sean P Polster et al.   NEUROSURGERY

The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation

(2018) Yitang Wang et al.   FASEB JOURNAL

Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

(2018) Miguel Alejandro Lopez-Ramirez et al.   BLOOD

Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells

(2018) Matthew R. Detter et al.   CIRCULATION RESEARCH

Co-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformations

(2017) Shouhei Noshiro et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations

(2017) Miguel Alejandro Lopez-Ramirez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage

(2017) Hussein A. Zeineddine et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations

(2017) Romuald Girard et al.   JOURNAL OF NEUROSURGERY

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

(2017) Alan T. Tang et al.   NATURE

Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel

(2017) Amy Akers et al.   NEUROSURGERY

Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations

(2017) Romuald Girard et al.   Translational Stroke Research

Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations: Clinical Correlations

(2016) H. Tan et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease

(2016) Romuald Girard et al.   Biomarkers in Medicine

Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin

(2016) Saverio Francesco Retta et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models

(2016) Changbin Shi et al.   Journal of Neuroimmune Pharmacology

Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease

(2016) Romuald Girard et al.   JOURNAL OF NEUROSCIENCE METHODS

Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data

(2016) Margaret A Horne et al.   LANCET NEUROLOGY

Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

(2016) Zinan Zhou et al.   NATURE

Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation

(2016) Huanjiao Jenny Zhou et al.   NATURE MEDICINE

Prevalence, Clinical Management, and Natural Course of Incidental Findings on Brain MR Images: The Population-based Rotterdam Scan Study

(2016) Daniel Bos et al.   RADIOLOGY

Endothelial Cells Lining Sporadic Cerebral Cavernous Malformation Cavernomas Undergo Endothelial-to-Mesenchymal Transition

(2016) Luca Bravi et al.   STROKE

RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations

(2016) Robert Shenkar et al.   STROKE

Propranolol Treatment of Cavernous Malformations with Symptomatic Hemorrhage

(2016) Joseph M. Zabramski et al.   World Neurosurgery

Building a roadmap to biomarker qualification: challenges and opportunities

(2015) Shashi G Amur et al.   Biomarkers in Medicine

Defective autophagy is a key feature of cerebral cavernous malformations

(2015) Saverio Marchi et al.   EMBO Molecular Medicine

Vascular Permeability in Cerebral Cavernous Malformations

(2015) Abdul G Mikati et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The utility of preoperative diffusion tensor imaging in the surgical management of brainstem cavernous malformations

(2015) Bruno C. Flores et al.   JOURNAL OF NEUROSURGERY

Characterization of radiation-induced cavernous malformations and comparison with a nonradiation cavernous malformation cohort

(2015) Jeremy K. Cutsforth-Gregory et al.   JOURNAL OF NEUROSURGERY

A Randomized, Controlled Trial of Oral Propranolol in Infantile Hemangioma

(2015) Christine Léauté-Labrèze et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sulindac metabolites decrease cerebrovascular malformations inCCM3-knockout mice

(2015) Luca Bravi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guidelines for the Management of Spontaneous Intracerebral Hemorrhage

(2015) J. Claude Hemphill et al.   STROKE

Gamma knife radiosurgery for brainstem cavernous malformations: should a patient wait for the rebleed?

(2014) Sung Ho Lee et al.   ACTA NEUROCHIRURGICA

Polymorphisms in Inflammatory and Immune Response Genes Associated with Cerebral Cavernous Malformation Type 1 Severity

(2014) Hélène Choquet et al.   CEREBROVASCULAR DISEASES

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations

(2014) Robert Shenkar et al.   GENETICS IN MEDICINE

Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis

(2014) David A. McDonald et al.   HUMAN MOLECULAR GENETICS

Evaluation of Iron Content in Human Cerebral Cavernous Malformation Using Quantitative Susceptibility Mapping

(2014) Huan Tan et al.   INVESTIGATIVE RADIOLOGY

KRIT1 Protein Depletion Modifies Endothelial Cell Behavior via Increased Vascular Endothelial Growth Factor (VEGF) Signaling

(2014) Peter V. DiStefano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune complex formation and in situ B-cell clonal expansion in human cerebral cavernous malformations

(2014) Changbin Shi et al.   JOURNAL OF NEUROIMMUNOLOGY

Stereotactic radiosurgery of brainstem cavernous malformations: a systematic review and meta-analysis

(2014) Xin-Yu Lu et al.   JOURNAL OF NEUROSURGERY

Long-term natural history of incidentally discovered cavernous malformations in a single-center cohort

(2014) S. Arthur Moore et al.   JOURNAL OF NEUROSURGERY

Surgical management and long-term outcome of pediatric patients with different subtypes of epilepsy associated with cerebral cavernous malformations

(2014) Christian von der Brelie et al.   Journal of Neurosurgery-Pediatrics

Surgical outcomes and natural history of intramedullary spinal cord cavernous malformations: a single-center series and meta-analysis of individual patient data

(2014) Jetan H. Badhiwala et al.   JOURNAL OF NEUROSURGERY-SPINE

Outcome after surgical or conservative management of cerebral cavernous malformations

(2014) F. Moultrie et al.   NEUROLOGY

Comparative studies of the diagnosis and treatment of cerebral cavernous malformations in adults: systematic review

(2013) Michiel Poorthuis et al.   ACTA NEUROCHIRURGICA

Cerebellar cavernous malformations with and without associated developmental venous anomalies

(2013) Peifeng Zhang et al.   BMC Neurology

Cavernoma-related epilepsy: Review and recommendations for management-Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies

(2013) Felix Rosenow et al.   EPILEPSIA

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

Dynamic Permeability and Quantitative Susceptibility

(2013) Abdul Ghani Mikati et al.   STROKE

Dynamic Contrast-Enhanced MRI Evaluation of Cerebral Cavernous Malformations

(2013) Blaine L. Hart et al.   Translational Stroke Research

Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study

(2012) Rustam Al-Shahi Salman et al.   LANCET NEUROLOGY

A call for transparent reporting to optimize the predictive value of preclinical research

(2012) Story C. Landis et al.   NATURE

Brainstem Cavernous Malformations: 1390 Surgical Cases from the Literature

(2012) Bradley A. Gross et al.   World Neurosurgery

Treatment of multiple sclerosis with Anti-CD20 antibodies

(2011) Barbara Barun et al.   CLINICAL IMMUNOLOGY

A founder mutation in the Ashkenazi Jewish population affecting messenger RNA splicing of the CCM2 gene causes cerebral cavernous malformations

(2011) Carol J Gallione et al.   GENETICS IN MEDICINE

Loss ofcerebral cavernous malformation 3(Ccm3) in neuroglia leads to CCM and vascular pathology

(2011) Angeliki Louvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease

(2011) David A. McDonald et al.   STROKE

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease

(2010) D. A. McDonald et al.   HUMAN MOLECULAR GENETICS

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

(2010) Rebecca A. Stockton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Magnetic Resonance Imaging Evaluation of Cerebral Cavernous Malformations With Susceptibility-Weighted Imaging

(2010) Nicolas Menjot de Champfleur et al.   NEUROSURGERY

Emerging clinical imaging techniques for cerebral cavernous malformations: a systematic review

(2010) Peter G. Campbell et al.   Neurosurgical Focus

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling

(2010) Joycelyn Wüstehube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

Regulation of cardiovascular development and integrity by the heart of glass–cerebral cavernous malformation protein pathway

(2009) Benjamin Kleaveland et al.   NATURE MEDICINE

CAVERNOUS MALFORMATIONS OF THE BASAL GANGLIA AND THALAMUS

(2009) Bradley A. Gross et al.   NEUROSURGERY

Immune Response in Human Cerebral Cavernous Malformations

(2009) Changbin Shi et al.   STROKE

Transsulcal approach supported by navigation-guided neurophysiological monitoring for resection of paracentral cavernomas

(2008) Hongyu Zhou et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

(2008) Amy L. Akers et al.   HUMAN MOLECULAR GENETICS

Hemorrhage From Cavernous Malformations of the Brain

(2008) Rustam Al-Shahi Salman et al.   STROKE