Organoid and pluripotent stem cells in Parkinson’s disease modeling: an expert view on their value to drug discovery
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Title
Organoid and pluripotent stem cells in Parkinson’s disease modeling: an expert view on their value to drug discovery
Authors
Keywords
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Journal
Expert Opinion on Drug Discovery
Volume -, Issue -, Pages 1-15
Publisher
Informa UK Limited
Online
2020-01-04
DOI
10.1080/17460441.2020.1703671
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Note: Only part of the references are listed.- Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase
- (2019) Jianbin Zheng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids
- (2019) Hongwon Kim et al. Stem Cell Reports
- Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson’s disease
- (2019) Liang Zhu et al. Cell Death & Disease
- Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
- (2019) Federico Zambon et al. HUMAN MOLECULAR GENETICS
- Increased lysosomal exocytosis induced by lysosomal Ca2+ channel agonists protects human dopaminergic neurons from α-synuclein toxicity
- (2019) Taiji Tsunemi et al. JOURNAL OF NEUROSCIENCE
- Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform
- (2019) Juan Antonio Garcia-Leon et al. Future Medicinal Chemistry
- Individual brain organoids reproducibly form cell diversity of the human cerebral cortex
- (2019) Silvia Velasco et al. NATURE
- Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease
- (2019) Roger A. Barker et al. NATURE MEDICINE
- Using stem cell–derived neurons in drug screening for neurological diseases
- (2019) Daniel Little et al. NEUROBIOLOGY OF AGING
- PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons
- (2019) Helle Bogetofte et al. Frontiers in Cellular Neuroscience
- Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson’s disease patients
- (2019) Rubén Fernández-Santiago et al. Clinical Epigenetics
- A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease
- (2019) Lena F. Burbulla et al. Science Translational Medicine
- Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson’s models
- (2018) Atossa Shaltouki et al. ACTA NEUROPATHOLOGICA
- Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function
- (2018) Myung Jong Kim et al. HUMAN MOLECULAR GENETICS
- MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients
- (2018) Eduard Tolosa et al. NEUROBIOLOGY OF AGING
- ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease
- (2018) Jorge S. Valadas et al. NEURON
- Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide
- (2018) Friederike Zunke et al. NEURON
- LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease
- (2018) Maria Nguyen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
- (2018) Iryna Prots et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers
- (2018) Sangjune Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease
- (2018) Qian Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
- (2018) Marthe H. R. Ludtmann et al. Nature Communications
- Optimizing the method for generation of integration-free induced pluripotent stem cells from human peripheral blood
- (2018) Haihui Gu et al. Stem Cell Research & Therapy
- The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease
- (2018) David C. Schöndorf et al. Cell Reports
- Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease
- (2018) Xian-Si Zeng et al. Frontiers in Aging Neuroscience
- Induced Pluripotent Stem Cells Generated from Adult Bone Marrow–Derived Cells of the Nonhuman Primate (Callithrix jacchus) Using a Novel Quad-Cistronic and Excisable Lentiviral Vector
- (2018) Anastasia Wiedemann et al. Cellular Reprogramming
- Progress and potential in organoid research
- (2018) Giuliana Rossi et al. NATURE REVIEWS GENETICS
- Advances in organ-on-a-chip engineering
- (2018) Boyang Zhang et al. Nature Reviews Materials
- Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes
- (2018) Charmaine Lang et al. Cell Stem Cell
- Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
- (2018) Saranna Fanning et al. MOLECULAR CELL
- Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease
- (2018) Maria Nguyen et al. TRENDS IN NEUROSCIENCES
- Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface
- (2017) Duc TT Phan et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila
- (2017) Alessandra Zanon et al. HUMAN MOLECULAR GENETICS
- Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons
- (2017) Sabrina M Heman-Ackah et al. HUMAN MOLECULAR GENETICS
- Cardiolipin promotes electron transport between ubiquinone and complex I to rescuePINK1deficiency
- (2017) Melissa Vos et al. JOURNAL OF CELL BIOLOGY
- A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells
- (2017) N Gunhanlar et al. MOLECULAR PSYCHIATRY
- Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model
- (2017) Tetsuhiro Kikuchi et al. NATURE
- Assembly of functionally integrated human forebrain spheroids
- (2017) Fikri Birey et al. NATURE
- α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
- (2017) Yvette C Wong et al. NATURE MEDICINE
- Generation of pure GABAergic neurons by transcription factor programming
- (2017) Nan Yang et al. NATURE METHODS
- iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
- (2017) Edsel M. Abud et al. NEURON
- A “dose” effect of mutations in the GBA gene on Parkinson's disease phenotype
- (2017) Avner Thaler et al. PARKINSONISM & RELATED DISORDERS
- Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease
- (2017) Georgia Kouroupi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- Dopamine Induces Oscillatory Activities in Human Midbrain Neurons with Parkin Mutations
- (2017) Ping Zhong et al. Cell Reports
- S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models
- (2017) Chang-Ki Oh et al. Cell Reports
- Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
- (2017) Anna S. Monzel et al. Stem Cell Reports
- Survival and dementia inGBA-associated Parkinson's disease: The mutation matters
- (2016) Roberto Cilia et al. ANNALS OF NEUROLOGY
- Heterozygous PINK1 p.G411S increases risk of Parkinson’s disease via a dominant-negative mechanism
- (2016) Andreas Puschmann et al. BRAIN
- Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons
- (2016) Junghyun Jo et al. Cell Stem Cell
- Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease
- (2016) Chung-Han Hsieh et al. Cell Stem Cell
- Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease
- (2016) Rodolfo Gonzalez et al. CELL TRANSPLANTATION
- Dishing out mini-brains: Current progress and future prospects in brain organoid research
- (2016) Iva Kelava et al. DEVELOPMENTAL BIOLOGY
- Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons
- (2016) Rakel López de Maturana et al. Journal of Neuroinflammation
- A New Glucocerebrosidase Chaperone Reduces -Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism
- (2016) E. Aflaki et al. JOURNAL OF NEUROSCIENCE
- Activation of -Glucocerebrosidase Reduces Pathological -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons
- (2016) J. R. Mazzulli et al. JOURNAL OF NEUROSCIENCE
- Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells
- (2016) Yao Hu et al. JOURNAL OF NEUROSCIENCE METHODS
- Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease
- (2016) Yvette C. Wong et al. MOVEMENT DISORDERS
- Structural disorder of monomeric α-synuclein persists in mammalian cells
- (2016) Francois-Xavier Theillet et al. NATURE
- Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
- (2016) Giambattista Guaitoli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
- (2016) Joseph R. Mazzulli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Projected increase in amyotrophic lateral sclerosis from 2015 to 2040
- (2016) Karissa C. Arthur et al. Nature Communications
- Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks
- (2016) Lena F. Burbulla et al. Advanced Healthcare Materials
- Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson’s Disease Patients
- (2016) Lin Lin et al. Cell Reports
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
- (2016) Hugo J.R. Fernandes et al. Stem Cell Reports
- Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation
- (2016) Sun Young Chung et al. Stem Cell Reports
- Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects
- (2016) Laurence Borgs et al. Scientific Reports
- Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease
- (2015) Penelope J. Hallett et al. Cell Stem Cell
- Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells
- (2015) F. T. Merkle et al. DEVELOPMENT
- (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation
- (2015) F. C. Fiesel et al. EMBO REPORTS
- The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications
- (2015) Thomas M. Durcan et al. GENES & DEVELOPMENT
- Parkinson's disease
- (2015) Lorraine V Kalia et al. LANCET
- Glucocerebrosidase and Parkinson disease: Recent advances
- (2015) Anthony H.V. Schapira MOLECULAR AND CELLULAR NEUROSCIENCE
- Generation of serotonin neurons from human pluripotent stem cells
- (2015) Jianfeng Lu et al. NATURE BIOTECHNOLOGY
- Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson's disease
- (2015) Tomoko Oeda et al. NEUROBIOLOGY OF AGING
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
- (2015) Cedric Bardy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells
- (2015) L M A Oliveira et al. Cell Death & Disease
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
- (2015) Ulf Dettmer et al. Nature Communications
- Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
- (2015) Benjamin S. Freedman et al. Nature Communications
- Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons
- (2015) Shuyan Wang et al. Scientific Reports
- Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines
- (2015) Atossa Shaltouki et al. Stem Cell Reports
- Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease
- (2014) Karen E. Murphy et al. BRAIN
- Genetic Insights into Sporadic Parkinson's Disease Pathogenesis
- (2014) Chou Chai et al. CURRENT GENOMICS
- Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N
- (2014) L. N. Munsie et al. HUMAN MOLECULAR GENETICS
- ATP13A2/PARK9 Regulates Secretion of Exosomes and -Synuclein
- (2014) T. Tsunemi et al. JOURNAL OF NEUROSCIENCE
- Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies
- (2014) G. Skibinski et al. JOURNAL OF NEUROSCIENCE
- A three-dimensional human neural cell culture model of Alzheimer’s disease
- (2014) Se Hoon Choi et al. NATURE
- PARK20 caused by SYNJ1 homozygous Arg258Gln mutation in a new Italian family
- (2014) Simone Olgiati et al. NEUROGENETICS
- iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
- (2014) David C. Schöndorf et al. Nature Communications
- iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
- (2014) Chris M. Woodard et al. Cell Reports
- Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells
- (2014) Diana Xuan Yu et al. Stem Cell Reports
- Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice
- (2014) Juthaporn Assawachananont et al. Stem Cell Reports
- Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
- (2013) Scott D. Ryan et al. CELL
- Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
- (2013) Gerald Schwank et al. Cell Stem Cell
- Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
- (2013) Justine D. Miller et al. Cell Stem Cell
- Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression
- (2013) Peter Reinhardt et al. Cell Stem Cell
- Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells
- (2013) Asif M. Maroof et al. Cell Stem Cell
- Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development
- (2013) Cory R. Nicholas et al. Cell Stem Cell
- Mutation in theSYNJ1Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism
- (2013) Marialuisa Quadri et al. HUMAN MUTATION
- The Sac1 Domain ofSYNJ1Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures
- (2013) Catharine E. Krebs et al. HUMAN MUTATION
- Cytosystems dynamics in self-organization of tissue architecture
- (2013) Yoshiki Sasai NATURE
- Vascularized and functional human liver from an iPSC-derived organ bud transplant
- (2013) Takanori Takebe et al. NATURE
- Cerebral organoids model human brain development and microcephaly
- (2013) Madeline A. Lancaster et al. NATURE
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
- (2013) Laurie H. Sanders et al. NEUROBIOLOGY OF DISEASE
- Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
- (2013) Yingsha Zhang et al. NEURON
- Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain
- (2013) Roger A. Barker et al. PROGRESS IN NEUROBIOLOGY
- Identification and Rescue of -Synuclein Toxicity in Parkinson Patient-Derived Neurons
- (2013) C. Y. Chung et al. SCIENCE
- Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
- (2012) Matthew E. Gegg et al. ANNALS OF NEUROLOGY
- Dominant-negative effects of LRRK2 heterodimers: A possible mechanism of neurodegeneration in Parkinson’s disease caused by LRRK2 I2020T mutation
- (2012) Etsuro Ohta et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs
- (2012) Tokushige Nakano et al. Cell Stem Cell
- Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
- (2012) Adriana Sánchez-Danés et al. EMBO Molecular Medicine
- Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
- (2012) Andrew W Greene et al. EMBO REPORTS
- Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks
- (2012) Yichen Shi et al. Nature Protocols
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Gene–environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models
- (2012) Jason R. Cannon et al. NEUROBIOLOGY OF DISEASE
- LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth
- (2012) Fumitaka Kawakami et al. PLoS One
- Induced Pluripotent Stem Cells Generated from Human Adipose-Derived Stem Cells Using a Non-Viral Polycistronic Plasmid in Feeder-Free Conditions
- (2012) Xinjian Qu et al. PLoS One
- Modeling human cortical development in vitro using induced pluripotent stem cells
- (2012) J. Mariani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
- (2012) O. Cooper et al. Science Translational Medicine
- Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
- (2012) Houbo Jiang et al. Nature Communications
- Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions
- (2012) Agnete Kirkeby et al. Cell Reports
- A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
- (2011) Alexander Zimprich et al. AMERICAN JOURNAL OF HUMAN GENETICS
- VPS35 Mutations in Parkinson Disease
- (2011) Carles Vilariño-Güell et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
- (2011) Ha Nam Nguyen et al. Cell Stem Cell
- Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
- (2011) L. Lapasset et al. GENES & DEVELOPMENT
- Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease
- (2011) Yong-Hee Rhee et al. JOURNAL OF CLINICAL INVESTIGATION
- Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells
- (2011) P. Seibler et al. JOURNAL OF NEUROSCIENCE
- Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
- (2011) Sonja Kriks et al. NATURE
- SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress
- (2011) Blake Byers et al. PLoS One
- Efficient Differentiation of Human Embryonic and Induced Pluripotent Stem Cells into Functional Astrocytes
- (2011) Luni Emdad et al. STEM CELLS AND DEVELOPMENT
- Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
- (2011) Michael J. Devine et al. Nature Communications
- Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells
- (2010) M. Nizzardo et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Gene–Environment Interactions in Parkinson's Disease: The Importance of Animal Modeling
- (2010) M P Horowitz et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases
- (2010) Y. Ren et al. HUMAN MOLECULAR GENETICS
- Large-scale screening of the Gaucher's disease-related glucocerebrosidase gene in Europeans with Parkinson's disease
- (2010) Suzanne Lesage et al. HUMAN MOLECULAR GENETICS
- Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
- (2010) Jason R. Spence et al. NATURE
- Direct conversion of fibroblasts to functional neurons by defined factors
- (2010) Thomas Vierbuchen et al. NATURE
- The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
- (2010) Mark R. Cookson NATURE REVIEWS NEUROSCIENCE
- Genetic Animal Models of Parkinson's Disease
- (2010) Ted M. Dawson et al. NEURON
- Gene–environment interactions in Parkinson's disease and other forms of parkinsonism
- (2010) Jeffery M. Vance et al. NEUROTOXICOLOGY
- Mitochondrial Rejuvenation After Induced Pluripotency
- (2010) Steven T. Suhr et al. PLoS One
- Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats
- (2010) G. Hargus et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
- (2009) Juliane Neumann et al. BRAIN
- Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells
- (2009) Rosa M. Marion et al. Cell Stem Cell
- Effective generation of iPS cells from CD34+ cord blood cells by inhibition of p53
- (2009) Chiemi Takenaka et al. EXPERIMENTAL HEMATOLOGY
- Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
- (2009) L. Parisiadou et al. JOURNAL OF NEUROSCIENCE
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- (2009) Stuart M Chambers et al. NATURE BIOTECHNOLOGY
- LRRK2 and GBA mutations differentially affect the initial presentation of Parkinson disease
- (2009) Z. Gan-Or et al. NEUROGENETICS
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells Survive and Integrate into 6-OHDA-Lesioned Rats
- (2009) Jingli Cai et al. STEM CELLS AND DEVELOPMENT
- Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
- (2008) M. Wernig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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