Conformationally active integrin endocytosis and traffic: why, where, when and how?

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem

(2019) Alexandre R. Gingras et al.   JOURNAL OF CELL BIOLOGY

GGA2 and RAB13 promote activity-dependent β1-integrin recycling

(2019) Pranshu Sahgal et al.   JOURNAL OF CELL SCIENCE

PI3K isoforms in cell signalling and vesicle trafficking

(2019) Benoit Bilanges et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Focal adhesion kinase-dependent activation of the early endocytic protein Rab5 is associated with cell migration

(2019) Cecilia Arriagada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of the polarized endothelial secretome

(2019) Haoche Wei et al.   FASEB JOURNAL

A kindlin-3–leupaxin–paxillin signaling pathway regulates podosome stability

(2019) Sarah Klapproth et al.   JOURNAL OF CELL BIOLOGY

Cell Adhesion by Integrins

(2019) Michael Bachmann et al.   PHYSIOLOGICAL REVIEWS

Rap1 and membrane lipids cooperatively recruit talin to trigger integrin activation

(2019) Thomas Bromberger et al.   JOURNAL OF CELL SCIENCE

Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion

(2019) Liang Zhu et al.   STRUCTURE

Unraveling the Mechanobiology of Extracellular Matrix

(2018) Viola Vogel   Annual Review of Physiology

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics

(2018) Thomas O'Loughlin et al.   EMBO REPORTS

Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions

(2018) Matthias Spiess et al.   JOURNAL OF CELL BIOLOGY

A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

(2018) Noemi Gioelli et al.   Science Translational Medicine

Reconstruction of the ancestral metazoan genome reveals an increase in genomic novelty

(2018) Jordi Paps et al.   Nature Communications

Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation

(2018) Paul Mellor et al.   Scientific Reports

Talin as a mechanosensitive signaling hub

(2018) Benjamin T. Goult et al.   JOURNAL OF CELL BIOLOGY

To degrade or not to degrade: mechanisms and significance of endocytic recycling

(2018) Peter J. Cullen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice

(2018) Thomas Bromberger et al.   BLOOD

Direct binding of Talin to Rap1 is required for cell–ECM adhesion in Drosophila

(2018) Darius Camp et al.   JOURNAL OF CELL SCIENCE

Integrin trafficking in cells and tissues

(2018) Paulina Moreno-Layseca et al.   NATURE CELL BIOLOGY

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Signal transduction via integrin adhesion complexes

(2018) Jonathan D Humphries et al.   CURRENT OPINION IN CELL BIOLOGY

AMPK negatively regulates tensin-dependent integrin activity

(2017) Maria Georgiadou et al.   JOURNAL OF CELL BIOLOGY

Patterned cell and matrix dynamics in branching morphogenesis

(2017) Shaohe Wang et al.   JOURNAL OF CELL BIOLOGY

Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity

(2017) Paul Atherton et al.   JOURNAL OF CELL SCIENCE

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

(2017) Johanna Lilja et al.   NATURE CELL BIOLOGY

The origin of Metazoa: a unicellular perspective

(2017) Arnau Sebé-Pedrós et al.   NATURE REVIEWS GENETICS

PLCε1 regulates SDF-1α–induced lymphocyte adhesion and migration to sites of inflammation

(2017) Marianne Strazza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stop or Go? Endosome Positioning in the Establishment of Compartment Architecture, Dynamics, and Function

(2017) Jacques Neefjes et al.   TRENDS IN CELL BIOLOGY

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Starved epithelial cells uptake extracellular matrix for survival

(2017) Taru Muranen et al.   Nature Communications

Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation

(2017) Liang Zhu et al.   Nature Communications

The Rap1-RIAM-talin axis of integrin activation and blood cell function

(2016) F. Lagarrigue et al.   BLOOD

Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts

(2016) Adam Byron et al.   CURRENT OPINION IN CELL BIOLOGY

The kindlin family: functions, signaling properties and implications for human disease

(2016) Emanuel Rognoni et al.   JOURNAL OF CELL SCIENCE

FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly

(2016) Guilherme P. F. Nader et al.   NATURE CELL BIOLOGY

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

(2016) J.-M. Dong et al.   Science Signaling

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis

(2016) Giulia Mana et al.   Nature Communications

Class 3 semaphorins in cardiovascular development

(2016) Donatella Valdembri et al.   Cell Adhesion & Migration

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

(2016) Marina Theodosiou et al.   eLife

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

(2016) J.-M. Dong et al.   Science Signaling

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

(2015) Tim S. Ellison et al.   Disease Models & Mechanisms

Neuropilin Functions as an Essential Cell Surface Receptor

(2015) Hou-Fu Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin endosomal signalling suppresses anoikis

(2015) Jonna Alanko et al.   NATURE CELL BIOLOGY

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

(2015) Elena Rainero et al.   Cell Reports

Endocytic trafficking of laminin is controlled by dystroglycan and is disrupted in cancers

(2014) D. Leonoudakis et al.   JOURNAL OF CELL SCIENCE

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

(2014) Samantha J. Stehbens et al.   NATURE CELL BIOLOGY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Organization and execution of the epithelial polarity programme

(2014) Enrique Rodriguez-Boulan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic dissection of plexin signaling in vivo

(2014) Thomas Worzfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability

(2014) Hong-Bo Pang et al.   Nature Communications

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding

(2014) Maria V Gelfand et al.   eLife

The GTPase-Activating Protein RN-tre Controls Focal Adhesion Turnover and Cell Migration

(2013) Andrea Palamidessi et al.   CURRENT BIOLOGY

Talin Autoinhibition Is Required for Morphogenesis

(2013) Stephanie J. Ellis et al.   CURRENT BIOLOGY

The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

(2013) Anthony Lanahan et al.   DEVELOPMENTAL CELL

Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction

(2013) Magdalena Chrzanowska-Wodnicka   EXPERIMENTAL CELL RESEARCH

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling

(2012) Chiara Sandri et al.   CELL RESEARCH

Distinct and Overlapping Roles for AP-1 and GGAs Revealed by the “Knocksideways” System

(2012) Jennifer Hirst et al.   CURRENT BIOLOGY

Regulation of adhesion site dynamics by integrin traffic

(2012) Donatella Valdembri et al.   CURRENT OPINION IN CELL BIOLOGY

The evolution of metazoan extracellular matrix

(2012) Richard O. Hynes   JOURNAL OF CELL BIOLOGY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex

(2012) Yu Wang et al.   JOURNAL OF CELL BIOLOGY

Integrin trafficking at a glance

(2012) R. E. Bridgewater et al.   JOURNAL OF CELL SCIENCE

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

Semaphorin Signaling Meets Rap

(2012) J. L. Bos et al.   Science Signaling

Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization

(2012) Y. Wang et al.   Science Signaling

Distinct Recycling of Active and Inactive β1 Integrins

(2012) Antti Arjonen et al.   TRAFFIC

Molecular Regulation of Lumen Morphogenesis

(2011) Anirban Datta et al.   CURRENT BIOLOGY

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

(2011) Marta A. Dozynkiewicz et al.   DEVELOPMENTAL CELL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration

(2011) Anja Mai et al.   JOURNAL OF CELL BIOLOGY

MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin

(2011) F. Shi et al.   JOURNAL OF CELL SCIENCE

Increasing traffic on vascular routes

(2011) Martina Santambrogio et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of integrins by conformation and traffic: it takes two to tango

(2011) Donatella Valdembri et al.   Molecular BioSystems

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

Protein scaffolds in the coupling of synaptic exocytosis and endocytosis

(2011) Volker Haucke et al.   NATURE REVIEWS NEUROSCIENCE

Regulating Rap small G-proteins in time and space

(2011) Martijn Gloerich et al.   TRENDS IN CELL BIOLOGY

Angiogenesis

(2011) D. R. Senger et al.   Cold Spring Harbor Perspectives in Biology

Fibronectins, Their Fibrillogenesis, and In Vivo Functions

(2011) J. E. Schwarzbauer et al.   Cold Spring Harbor Perspectives in Biology

Collagen I matrix turnover is regulated by fibronectin polymerization

(2010) Feng Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis

(2010) Anthony A. Lanahan et al.   DEVELOPMENTAL CELL

β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism

(2010) Ann C. Zovein et al.   DEVELOPMENTAL CELL

Analysis of integrin turnover in fly myotendinous junctions

(2010) Lin Yuan et al.   JOURNAL OF CELL SCIENCE

Ancient origin of the integrin-mediated adhesion and signaling machinery

(2010) A. Sebe-Pedros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibronectins in vascular morphogenesis

(2009) Sophie Astrof et al.   ANGIOGENESIS

Cellular and Molecular Mechanisms of Vascular Lumen Formation

(2009) M. Luisa Iruela-Arispe et al.   DEVELOPMENTAL CELL

The mechanical integrin cycle

(2009) E. Puklin-Faucher et al.   JOURNAL OF CELL SCIENCE

Anti-integrin monoclonal antibodies

(2009) A. Byron et al.   JOURNAL OF CELL SCIENCE

Rab5 Mediates Caspase-8–promoted Cell Motility and Metastasis

(2009) Vicente A. Torres et al.   MOLECULAR BIOLOGY OF THE CELL

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocytic Trafficking of Rac Is Required for the Spatial Restriction of Signaling in Cell Migration

(2008) Andrea Palamidessi et al.   CELL

Integrin Trafficking Regulated by Rab21 Is Necessary for Cytokinesis

(2008) Teijo Pellinen et al.   DEVELOPMENTAL CELL

Caveolin-1-dependent  1 integrin endocytosis is a critical regulator of fibronectin turnover

(2008) F. Shi et al.   JOURNAL OF CELL SCIENCE

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

(2008) Nicole King et al.   NATURE