Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
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Title
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
Authors
Keywords
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Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 15, Issue 9, Pages 577-590
Publisher
Springer Nature
Online
2014-08-22
DOI
10.1038/nrm3861
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Note: Only part of the references are listed.- Asymmetry of Single Cells and Where That Leads
- (2014) Mark S. Bretscher Annual Review of Biochemistry
- The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton
- (2014) Baoyu Chen et al. CELL
- JMY is involved in anterograde vesicle trafficking from the trans-Golgi network
- (2014) Kai Schlüter et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- High GMFG expression correlates with poor prognosis and promotes cell migration and invasion in epithelial ovarian cancer
- (2014) Peng Zuo et al. GYNECOLOGIC ONCOLOGY
- The Adaptor Proteins p66Shc and Grb2 Regulate the Activation of the GTPases ARF1 and ARF6 in Invasive Breast Cancer Cells
- (2014) Eric Haines et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mathematical Modeling of Eukaryotic Cell Migration: Insights Beyond Experiments
- (2013) Gaudenz Danuser et al. Annual Review of Cell and Developmental Biology
- Microtubules in Cell Migration
- (2013) Sandrine Etienne-Manneville Annual Review of Cell and Developmental Biology
- Mitochondrial Localization and the Persistent Migration of Epithelial Cancer cells
- (2013) Salil P. Desai et al. BIOPHYSICAL JOURNAL
- GMF Severs Actin-Arp2/3 Complex Branch Junctions by a Cofilin-like Mechanism
- (2013) Casey A. Ydenberg et al. CURRENT BIOLOGY
- Dip1 Defines a Class of Arp2/3 Complex Activators that Function without Preformed Actin Filaments
- (2013) Andrew R. Wagner et al. CURRENT BIOLOGY
- Actin Filament Severing by Cofilin Dismantles Actin Patches and Produces Mother Filaments for New Patches
- (2013) Qian Chen et al. CURRENT BIOLOGY
- The role and regulation of blebs in cell migration
- (2013) Ewa K Paluch et al. CURRENT OPINION IN CELL BIOLOGY
- Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion
- (2013) R. Moore et al. DEVELOPMENT
- Exo70 Isoform Switching upon Epithelial-Mesenchymal Transition Mediates Cancer Cell Invasion
- (2013) Hezhe Lu et al. DEVELOPMENTAL CELL
- Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis
- (2013) Anne Vehlow et al. EMBO JOURNAL
- CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP
- (2013) Andrea Disanza et al. EMBO JOURNAL
- The expression of glia maturation factors and the effect of glia maturation factor-γ on angiogenic sprouting in zebrafish
- (2013) Peng Zuo et al. EXPERIMENTAL CELL RESEARCH
- Glia Maturation Factor (GMF) Interacts with Arp2/3 Complex in a Nucleotide State-dependent Manner
- (2013) Malgorzata Boczkowska et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo
- (2013) Ah-Lai Law et al. JOURNAL OF CELL BIOLOGY
- Loss of Arp2/3 induces an NF-κB–dependent, nonautonomous effect on chemotactic signaling
- (2013) Congying Wu et al. JOURNAL OF CELL BIOLOGY
- Mechanisms of cell migration in the nervous system
- (2013) Jonathan A. Cooper JOURNAL OF CELL BIOLOGY
- Signaling inputs to invadopodia and podosomes
- (2013) D. Hoshino et al. JOURNAL OF CELL SCIENCE
- Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation
- (2013) A. Steffen et al. JOURNAL OF CELL SCIENCE
- Filamin A Regulates Neuronal Migration through Brefeldin A-Inhibited Guanine Exchange Factor 2-Dependent Arf1 Activation
- (2013) J. Zhang et al. JOURNAL OF NEUROSCIENCE
- Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration
- (2013) Matthew C. Jones et al. MOLECULAR BIOLOGY OF THE CELL
- srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity
- (2013) Daisuke Yamazaki et al. MOLECULAR BIOLOGY OF THE CELL
- Structural basis for regulation of Arp2/3 complex by GMF
- (2013) Qing Luan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Small GTPase Arf1 Modulates Arp2/3-Mediated Actin Polymerization via PICK1 to Regulate Synaptic Plasticity
- (2013) Daniel L. Rocca et al. NEURON
- SPIN90 Knockdown Attenuates the Formation and Movement of Endosomal Vesicles in the Early Stages of Epidermal Growth Factor Receptor Endocytosis
- (2013) Hyejin Oh et al. PLoS One
- Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells
- (2013) D. Humphreys et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Beyond symmetry-breaking: competition and negative feedback in GTPase regulation
- (2013) Chi-Fang Wu et al. TRENDS IN CELL BIOLOGY
- CARMIL leading edge localization depends on a non-canonical PH domain and dimerization
- (2013) Adam Zwolak et al. Nature Communications
- Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP
- (2013) Luke A Helgeson et al. eLife
- Glia maturation factor gamma regulates the migration and adherence of human T lymphocytes
- (2012) Dustin ND Lippert et al. BMC IMMUNOLOGY
- Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis
- (2012) Congying Wu et al. CELL
- Role of Coronin 1B in PDGF-Induced Migration of Vascular Smooth Muscle Cells
- (2012) Holly C. Williams et al. CIRCULATION RESEARCH
- Pseudopod Growth and Evolution during Cell Movement Is Controlled through SCAR/WAVE Dephosphorylation
- (2012) Seiji Ura et al. CURRENT BIOLOGY
- Exo70 Stimulates the Arp2/3 Complex for Lamellipodia Formation and Directional Cell Migration
- (2012) Jianglan Liu et al. CURRENT BIOLOGY
- FMNL2 Drives Actin-Based Protrusion and Migration Downstream of Cdc42
- (2012) Jennifer Block et al. CURRENT BIOLOGY
- Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion
- (2012) Haoran Tang et al. CURRENT BIOLOGY
- Traveling waves in actin dynamics and cell motility
- (2012) Jun Allard et al. CURRENT OPINION IN CELL BIOLOGY
- A review of models of fluctuating protrusion and retraction patterns at the leading edge of motile cells
- (2012) Gillian L. Ryan et al. Cytoskeleton
- SCAR knockouts inDictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods
- (2012) Douwe M. Veltman et al. JOURNAL OF CELL BIOLOGY
- Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow
- (2012) Qing Yang et al. JOURNAL OF CELL BIOLOGY
- The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration
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- The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation
- (2012) D. Humphreys et al. JOURNAL OF CELL SCIENCE
- Actin branching in the initiation and maintenance of lamellipodia
- (2012) M. Vinzenz et al. JOURNAL OF CELL SCIENCE
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- Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex
- (2012) T. Maritzen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2012) A.-C. Reymann et al. SCIENCE
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- (2012) Shiro Suetsugu et al. TRENDS IN CELL BIOLOGY
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- Life at the Leading Edge
- (2011) Anne J. Ridley CELL
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- (2011) Bong Hwan Sung et al. CURRENT BIOLOGY
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- Molecular mechanism of Ena/VASP-mediated actin-filament elongation
- (2011) Dennis Breitsprecher et al. EMBO JOURNAL
- Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation
- (2011) Antonio Castro-Castro et al. EMBO JOURNAL
- PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity
- (2011) Yasuko Nakamura et al. EMBO JOURNAL
- Mechanism of a Concentration-dependent Switch between Activation and Inhibition of Arp2/3 Complex by Coronin
- (2011) Su-Ling Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Clathrin is required for Scar/Wave-mediated lamellipodium formation
- (2011) J. J. Gautier et al. JOURNAL OF CELL SCIENCE
- SrGAP3 interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions
- (2011) V. Endris et al. JOURNAL OF CELL SCIENCE
- The actin nucleation factor JMY is a negative regulator of neuritogenesis
- (2011) Elif Nur Firat-Karalar et al. MOLECULAR BIOLOGY OF THE CELL
- Glioblastoma motility occurs in the absence of actin polymer
- (2011) Andreas Panopoulos et al. MOLECULAR BIOLOGY OF THE CELL
- SH3BP1, an Exocyst-Associated RhoGAP, Inactivates Rac1 at the Front to Drive Cell Motility
- (2011) Maria Carla Parrini et al. MOLECULAR CELL
- ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex
- (2011) Michelle C. Mendoza et al. MOLECULAR CELL
- Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex
- (2011) S.-C. Ti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- WAVE regulatory complex activation by cooperating GTPases Arf and Rac1
- (2011) V. Koronakis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Arp2/3 complex is bound and activated by two WASP proteins
- (2011) S. B. Padrick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel
- (2011) Renaud Poincloux et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Unraveling the enigma: progress towards understanding the coronin family of actin regulators
- (2011) Keefe T. Chan et al. TRENDS IN CELL BIOLOGY
- Control of Actin Filament Treadmilling in Cell Motility
- (2010) Beáta Bugyi et al. Annual Review of Biophysics
- Generation of branched actin networks: assembly and regulation of the N-WASP and WAVE molecular machines
- (2010) Emmanuel Derivery et al. BIOESSAYS
- Sequence-Dependent Sorting of Recycling Proteins by Actin-Stabilized Endosomal Microdomains
- (2010) Manojkumar A. Puthenveedu et al. CELL
- GMF Is a Cofilin Homolog that Binds Arp2/3 Complex to Stimulate Filament Debranching and Inhibit Actin Nucleation
- (2010) Meghal Gandhi et al. CURRENT BIOLOGY
- A “Primer”-Based Mechanism Underlies Branched Actin Filament Network Formation and Motility
- (2010) Vérane Achard et al. CURRENT BIOLOGY
- c-Abl, Lamellipodin, and Ena/VASP Proteins Cooperate in Dorsal Ruffling of Fibroblasts and Axonal Morphogenesis
- (2010) Magdalene Michael et al. CURRENT BIOLOGY
- Identification of glia maturation factor beta as an independent prognostic predictor for serous ovarian cancer
- (2010) Yan Li Li et al. EUROPEAN JOURNAL OF CANCER
- VASP is a processive actin polymerase that requires monomeric actin for barbed end association
- (2010) Scott D. Hansen et al. JOURNAL OF CELL BIOLOGY
- Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion inDrosophilamacrophages in vivo
- (2010) Brian Stramer et al. JOURNAL OF CELL BIOLOGY
- Cdc42 localization and cell polarity depend on membrane traffic
- (2010) Naël Osmani et al. JOURNAL OF CELL BIOLOGY
- Myosin II contributes to cell-scale actin network treadmilling through network disassembly
- (2010) Cyrus A. Wilson et al. NATURE
- Structure and control of the actin regulatory WAVE complex
- (2010) Zhucheng Chen et al. NATURE
- Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin–AP-1-coated carrier biogenesis at the TGN
- (2010) Mihaela Anitei et al. NATURE CELL BIOLOGY
- A nucleator arms race: cellular control of actin assembly
- (2010) Kenneth G. Campellone et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Cells navigate with a local-excitation, global-inhibition-biased excitable network
- (2010) Y. Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasis
- (2010) Jill Kuglin Schweitzer et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond
- (2010) Klemens Rottner et al. TRENDS IN CELL BIOLOGY
- Neutrophils Establish Rapid and Robust WAVE Complex Polarity in an Actin-Dependent Fashion
- (2009) Arthur Millius et al. CURRENT BIOLOGY
- Actin nucleation and elongation factors: mechanisms and interplay
- (2009) Melissa A Chesarone et al. CURRENT OPINION IN CELL BIOLOGY
- Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks
- (2009) Robert H. Insall et al. DEVELOPMENTAL CELL
- How tropomyosin regulates lamellipodial actin-based motility: a combined biochemical and reconstituted motility approach
- (2009) Beáta Bugyi et al. EMBO JOURNAL
- DIP/WISH-deficient mice reveal Dia- and N-WASP-interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts
- (2009) Tomoko Fukumi-Tominaga et al. GENES TO CELLS
- Direct Observation of the Uncapping of Capping Protein-capped Actin Filaments by CARMIL Homology Domain 3
- (2009) Ikuko Fujiwara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Distinct Roles for CARMIL Isoforms in Cell Migration
- (2009) Yun Liang et al. MOLECULAR BIOLOGY OF THE CELL
- Cortactin Promotes Migration and Platelet-derived Growth Factor-induced Actin Reorganization by Signaling to Rho-GTPases
- (2009) Frank P.L. Lai et al. MOLECULAR BIOLOGY OF THE CELL
- Activation of the WAVE Complex by Coincident Signals Controls Actin Assembly
- (2009) Andres M. Lebensohn et al. MOLECULAR CELL
- Coronin Switches Roles in Actin Disassembly Depending on the Nucleotide State of Actin
- (2009) Meghal Gandhi et al. MOLECULAR CELL
- p53-cofactor JMY is a multifunctional actin nucleation factor
- (2009) J. Bradley Zuchero et al. NATURE CELL BIOLOGY
- Random versus directionally persistent cell migration
- (2009) Ryan J. Petrie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The WAVE regulatory complex is inhibited
- (2009) Ayman M Ismail et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A transcription co-factor integrates cell adhesion and motility with the p53 response
- (2009) A. S. Coutts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multi-level molecular clutches in motile cell processes
- (2009) Grégory Giannone et al. TRENDS IN CELL BIOLOGY
- New players in actin polymerization – WH2-domain-containing actin nucleators
- (2009) Britta Qualmann et al. TRENDS IN CELL BIOLOGY
- The Wave complex is intrinsically inactive
- (2009) Emmanuel Derivery et al. CELL MOTILITY AND THE CYTOSKELETON
- Coronin 1B Antagonizes Cortactin and Remodels Arp2/3-Containing Actin Branches in Lamellipodia
- (2008) Liang Cai et al. CELL
- WHAMM Is an Arp2/3 Complex Activator That Binds Microtubules and Functions in ER to Golgi Transport
- (2008) Kenneth G. Campellone et al. CELL
- A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis
- (2008) Ulrike Philippar et al. DEVELOPMENTAL CELL
- Arp2/3 complex interactions and actin network turnover in lamellipodia
- (2008) Frank PL Lai et al. EMBO JOURNAL
- Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation
- (2008) Dennis Breitsprecher et al. EMBO JOURNAL
- ADP-ribosylation Factor 1 Controls the Activation of the Phosphatidylinositol 3-Kinase Pathway to Regulate Epidermal Growth Factor-dependent Growth and Migration of Breast Cancer Cells
- (2008) Pierre-Luc Boulay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ena/VASP Proteins Capture Actin Filament Barbed Ends
- (2008) Lejla Pasic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Filopodia formation induced by active mDia2/Drf3
- (2008) J. BLOCK et al. JOURNAL OF MICROSCOPY
- Cdk5 Phosphorylation of WAVE2 Regulates Oligodendrocyte Precursor Cell Migration through Nonreceptor Tyrosine Kinase Fyn
- (2008) Y. Miyamoto et al. JOURNAL OF NEUROSCIENCE
- Hierarchical Regulation of WASP/WAVE Proteins
- (2008) Shae B. Padrick et al. MOLECULAR CELL
- Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis
- (2008) Daniel L. Rocca et al. NATURE CELL BIOLOGY
- Design principles of biochemical oscillators
- (2008) Béla Novák et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Crosstalk between small GTPases and polarity proteins in cell polarization
- (2008) Sandra Iden et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Feedback Loops Shape Cellular Signals in Space and Time
- (2008) O. Brandman et al. SCIENCE
- WAVE2 is regulated by multiple phosphorylation events within its VCA domain
- (2008) Shirin M. Pocha et al. CELL MOTILITY AND THE CYTOSKELETON
- Coronin-1A Stabilizes F-Actin by Bridging Adjacent Actin Protomers and Stapling Opposite Strands of the Actin Filament
- (2007) Vitold E. Galkin et al. JOURNAL OF MOLECULAR BIOLOGY
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