Class 3 semaphorins in cardiovascular development

Semaphorin 3A attenuates cardiac autonomic disorders and reduces inducible ventricular arrhythmias in rats with experimental myocardial infarction

(2016) Hesheng Hu et al.   BMC Cardiovascular Disorders

Endothelial cell-derived semaphorin 3A inhibits filopodia formation by blood vascular tip cells

(2016) Alexandra M. Ochsenbein et al.   DEVELOPMENT

Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor

(2016) Haig Aghajanian et al.   Nature Communications

Semaphorin Signaling in Cardiovascular Development

(2015) Jonathan A. Epstein et al.   Cell Metabolism

Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis

(2015) W.-J. Yang et al.   EMBO Molecular Medicine

Neuropilin Functions as an Essential Cell Surface Receptor

(2015) Hou-Fu Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural crest–derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation

(2015) Alice Plein et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

(2015) Matthew W. Parker et al.   STRUCTURE

Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic cell-penetrating peptides

(2015) H.-B. Pang et al.   Science Advances

Semaphorin 3d and Semaphorin 3e Direct Endothelial Motility through Distinct Molecular Signaling Pathways

(2014) Haig Aghajanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Semaphorins and plexins as therapeutic targets

(2014) Thomas Worzfeld et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic dissection of plexin signaling in vivo

(2014) Thomas Worzfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fetal, but Not Postnatal, Deletion of Semaphorin-Neuropilin-1 Signaling Affects Murine Alveolar Development

(2013) Stephen Joza et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanistic Basis for the Potent Anti-Angiogenic Activity of Semaphorin 3F

(2013) Hou-Fu Guo et al.   BIOCHEMISTRY

NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis

(2013) A. Fantin et al.   BLOOD

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Resolution of defective dorsal aortae patterning in Sema3E-deficient mice occurs via angiogenic remodeling

(2013) Stryder M. Meadows et al.   DEVELOPMENTAL DYNAMICS

Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction

(2013) Magdalena Chrzanowska-Wodnicka   EXPERIMENTAL CELL RESEARCH

Overexpression of sema3a in myocardial infarction border zone decreases vulnerability of ventricular tachycardia post-myocardial infarction in rats

(2013) Ren-Hua Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia

(2013) Yan Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Class 3 semaphorins: physiological vascular normalizing agents for anti-cancer therapy

(2013) G. Serini et al.   JOURNAL OF INTERNAL MEDICINE

Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections

(2013) Karl Degenhardt et al.   NATURE MEDICINE

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Semaphorins in Angiogenesis and Tumor Progression

(2013) G. Neufeld et al.   Cold Spring Harbor Perspectives in Medicine

A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation

(2013) Yukiko Nakano et al.   PLoS Genetics

Loss of Semaphorin-Neuropilin-1 Signaling Causes Dysmorphic Vascularization Reminiscent of Alveolar Capillary Dysplasia

(2012) Stephen Joza et al.   AMERICAN JOURNAL OF PATHOLOGY

Function of Members of the Neuropilin Family as Essential Pleiotropic Cell Surface Receptors

(2012) Matthew W. Parker et al.   BIOCHEMISTRY

Distinct Compartments of the Proepicardial Organ Give Rise to Coronary Vascular Endothelial Cells

(2012) Tamar C. Katz et al.   DEVELOPMENTAL CELL

Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

(2012) Matthew W. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex

(2012) Bert J C Janssen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition

(2012) Matthew W. Parker et al.   PLoS One

Structural insights into semaphorins and their receptors

(2012) Christian Siebold et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling

(2011) B. Kigel et al.   BLOOD

Integration of Repulsive Guidance Cues Generates Avascular Zones That Shape Mammalian Blood Vessels

(2011) Stryder M. Meadows et al.   CIRCULATION RESEARCH

Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1

(2011) Tomasz Zygmunt et al.   DEVELOPMENTAL CELL

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential Endothelial Transcriptomics Identifies Semaphorin 3G as a Vascular Class 3 Semaphorin

(2010) Simone Kutschera et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Furin Processing of Semaphorin 3F Determines Its Anti-Angiogenic Activity by Regulating Direct Binding and Competition for Neuropilin

(2010) Matthew W. Parker et al.   BIOCHEMISTRY

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching

(2010) G. A. Strasser et al.   BLOOD

Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1

(2010) Heli Liu et al.   CELL

Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

(2010) Andrea Casazza et al.   JOURNAL OF CLINICAL INVESTIGATION

Semaphorin 3E Initiates Antiangiogenic Signaling through Plexin D1 by Regulating Arf6 and R-Ras

(2010) A. Sakurai et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis of semaphorin–plexin signalling

(2010) Bert J. C. Janssen et al.   NATURE

Structural basis for semaphorin signalling through the plexin receptor

(2010) Terukazu Nogi et al.   NATURE

Semaphorin3a regulates endothelial cell number and podocyte differentiation during glomerular development

(2009) K. J. Reidy et al.   DEVELOPMENT

Antagonistic interactions among Plexins regulate the timing of intersegmental vessel formation

(2009) Ryan E. Lamont et al.   DEVELOPMENTAL BIOLOGY

Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology

(2009) Yasuhiro Saito et al.   EMBO REPORTS

Structure and Function of the Intracellular Region of the Plexin-B1 Transmembrane Receptor

(2009) Yufeng Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Semaphorin-3B Is an Angiogenesis Inhibitor That Is Inactivated by Furin-Like Pro-Protein Convertases

(2008) A. Varshavsky et al.   CANCER RESEARCH

Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells

(2008) Toshihiko Toyofuku et al.   DEVELOPMENTAL BIOLOGY

Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects

(2008) Ying Zhang et al.   DEVELOPMENTAL BIOLOGY

Three-Dimensional Analysis of Vascular Development in the Mouse Embryo

(2008) Johnathon R. Walls et al.   PLoS One