A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs
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Title
A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs
Authors
Keywords
Dogs, Cardiac aging, Rapamycin, Echocardiogram, Blood chemistry, Healthspan, Sirolimus
Journal
GeroScience
Volume 39, Issue 2, Pages 117-127
Publisher
Springer Nature
Online
2017-04-03
DOI
10.1007/s11357-017-9972-z
References
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Note: Only part of the references are listed.- Geroscience and the trans-NIH Geroscience Interest Group, GSIG
- (2017) Felipe Sierra et al. GeroScience
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- (2017) Silvan R. Urfer et al. GeroScience
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- (2016) Jeanne C. Larson et al. AMERICAN JOURNAL OF VETERINARY RESEARCH
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- (2016) Jehill D. Parikh et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- The dog aging project: translational geroscience in companion animals
- (2016) Matt Kaeberlein et al. MAMMALIAN GENOME
- Hyperglycemia and Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) Inhibitors in Phase I Trials: Incidence, Predictive Factors, and Management
- (2016) Khurum H. Khan et al. ONCOLOGIST
- Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
- (2016) Alessandro Bitto et al. eLife
- Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus)
- (2015) Corinna Ross et al. Aging-US
- Why is the dog an ideal model for aging research?
- (2015) Keiva M. Gilmore et al. EXPERIMENTAL GERONTOLOGY
- Healthy aging: The ultimate preventative medicine
- (2015) M. Kaeberlein et al. SCIENCE
- Why Is Aging Conserved and What Can We Do about It?
- (2015) Jason N. Pitt et al. PLOS BIOLOGY
- Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life
- (2015) Kathleen E. Fischer et al. PLoS One
- Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
- (2014) Dao-Fu Dai et al. AGING CELL
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- Rapamycin and Ageing: When, for How Long, and How Much?
- (2014) Matt Kaeberlein Journal of Genetics and Genomics
- Correction of glycogen storage disease type III with rapamycin in a canine model
- (2014) Haiqing Yi et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset
- (2014) Suzette Tardif et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- mTOR inhibition improves immune function in the elderly
- (2014) J. B. Mannick et al. Science Translational Medicine
- Late-life rapamycin treatment reverses age-related heart dysfunction
- (2013) James M. Flynn et al. AGING CELL
- The Hallmarks of Aging
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- (2013) Frauke Neff et al. JOURNAL OF CLINICAL INVESTIGATION
- Relationship Between Mean Corpuscular Volume and Cognitive Performance in Older Adults
- (2013) Alyssa A. Gamaldo et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Preserving Youth: Does Rapamycin Deliver?
- (2013) S. C. Johnson et al. Science Translational Medicine
- Rapamycin slows aging in mice
- (2012) John E. Wilkinson et al. AGING CELL
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
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- (2012) Vladimir N. Anisimov et al. CELL CYCLE
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- (2012) J. Halloran et al. NEUROSCIENCE
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- (2012) D. W. Lamming et al. SCIENCE
- Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling
- (2011) Smita Majumder et al. AGING CELL
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- (2011) J. Weinreich et al. EUROPEAN SURGICAL RESEARCH
- Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
- (2010) Richard A. Miller et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs
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- mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
- (2009) C. Chen et al. Science Signaling
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