Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases

Sensing Membrane Curvature in Macroautophagy

(2017) Nathan Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation

(2017) Jana Sánchez-Wandelmer et al.   Nature Communications

The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane

(2016) Do Hoon Kwon et al.   Autophagy

Autophagy in the test tube:In vitroreconstitution of aspects of autophagosome biogenesis

(2016) Yijian Rao et al.   FEBS Journal

Accessory Interaction Motifs in the Atg19 Cargo Receptor Enable Strong Binding to the Clustered Ubiquitin-related Atg8 Protein

(2016) Christine Abert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane

(2016) Kotaro Tsuboyama et al.   SCIENCE

Identification of breast cancer cell subtypes sensitive to ATG4B inhibition

(2016) Svetlana Bortnik et al.   Oncotarget

O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity

(2016) Yoon Kyung Jo et al.   Oncotarget

AU4S: A novel synthetic peptide to measure the activity of ATG4 in living cells

(2015) Zhenhong Ni et al.   Autophagy

Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis

(2015) Sandra Cabrera et al.   Autophagy

The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs

(2015) Florian A. Horenkamp et al.   DEVELOPMENTAL CELL

ATG4B (Autophagin-1) Phosphorylation Modulates Autophagy

(2015) Zhifen Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro systems for Atg8 lipidation

(2015) Bettina Zens et al.   METHODS

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

(2015) Shuxi Qiao et al.   Nature Communications

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

Molecular Mechanism of Autophagic Membrane-Scaffold Assembly and Disassembly

(2014) Anna Kaufmann et al.   CELL

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures

(2014) A. H. Lystad et al.   EMBO REPORTS

Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3

(2014) Sangeeta Nath et al.   NATURE CELL BIOLOGY

Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane–cargo apposition during selective autophagy

(2014) Justyna Sawa-Makarska et al.   NATURE CELL BIOLOGY

Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins

(2014) Daniel J Klionsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane Morphology Is Actively Transformed by Covalent Binding of the Protein Atg8 to PE-Lipids

(2014) Roland L. Knorr et al.   PLoS One

Dissecting the role of the Atg12–Atg5-Atg16 complex during autophagosome formation

(2013) Marta Walczak et al.   Autophagy

The Carboxyl-Terminal Amino Acids Render Pro-Human LC3B Migration Similar to Lipidated LC3B in SDS-PAGE

(2013) Wei Wang et al.   PLoS One

A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress

(2012) Virginie M.S. Betin et al.   Autophagy

Dual roles of Atg8−PE deconjugation by Atg4 in autophagy

(2012) Zhong-Qiu Yu et al.   Autophagy

A role for Atg8–PE deconjugation in autophagosome biogenesis

(2012) Usha Nair et al.   Autophagy

Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis

(2012) Hitoshi Nakatogawa et al.   Autophagy

A high-throughput FRET-based assay for determination of Atg4 activity

(2012) Min Li et al.   Autophagy

Differential Function of the Two Atg4 Homologues in the Aggrephagy Pathway inCaenorhabditis elegans

(2012) Fan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

(2012) A. Choy et al.   SCIENCE

Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection

(2012) Ersheng Kuang et al.   PLoS Genetics

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates

(2010) Min Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

(2010) Serhiy Pankiv et al.   JOURNAL OF CELL BIOLOGY

Autophagy is essential for mouse sense of balance

(2010) Guillermo Mariño et al.   JOURNAL OF CLINICAL INVESTIGATION

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasiteLeishmania major

(2009) Roderick A.M. Williams et al.   Autophagy

The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

(2009) Kenji Satoo et al.   EMBO JOURNAL

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

Physiological pH and Acidic Phospholipids Contribute to Substrate Specificity in Lipidation of Atg8

(2008) Kyoko Oh-oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg8 Controls Phagophore Expansion during Autophagosome Formation

(2008) Zhiping Xie et al.   MOLECULAR BIOLOGY OF THE CELL

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL