Hemolysis Derived Products Toxicity and Endothelium: Model of the Second Hit

Endothelium structure and function in kidney health and disease

(2019) Noemie Jourde-Chiche et al.   Nature Reviews Nephrology

Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1

(2019) Hatem Maamoun et al.   Frontiers in Physiology

Complement activation during intravascular hemolysis: Implication for sickle cell disease and hemolytic transfusion reactions

(2019) N.S. Merle et al.   TRANSFUSION CLINIQUE ET BIOLOGIQUE

P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

(2019) Nicolas S. Merle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

(2019) Wenjun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

S100A8 acts as an autocrine priming signal for heme‐induced human Mϕ pro‐inflammatory responses in hemolytic inflammation

(2019) Angélica A. A. Silveira et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance

(2019) Yan Wang et al.   ENVIRONMENTAL POLLUTION

Heme, Heme Oxygenase, and Endoplasmic Reticulum Stress—A New Insight into the Pathophysiology of Vascular Diseases

(2019) Gáll et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical promise of next-generation complement therapeutics

(2019) Dimitrios C. Mastellos et al.   NATURE REVIEWS DRUG DISCOVERY

Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice

(2019) Aleksandra Bednarz et al.   Scientific Reports

HO-1 overexpression and underexpression: Clinical implications

(2019) George S. Drummond et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Labile heme impairs hepatic microcirculation and promotes hepatic injury

(2019) Franziska A. Englert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Phenotypically-Silent Bone Morphogenetic Protein Receptor 2 ( Bmpr2 ) Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing The Risk for Neointimal Transformation

(2019) Wen Tian et al.   CIRCULATION

HO-1 mitigates acute kidney injury and subsequent kidney-lung cross-talk

(2019) Maxime Rossi et al.   FREE RADICAL RESEARCH

Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood

(2019) Anub M. Thomas et al.   JOURNAL OF IMMUNOLOGY

Use of cysteine as a spectroscopic probe for determination of heme-scavenging capacity of serum proteins and whole human serum

(2019) Rémi Noé et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Use of Highly Individualized Complement Blockade Has Revolutionized Clinical Outcomes after Kidney Transplantation and Renal Epidemiology of Atypical Hemolytic Uremic Syndrome

(2019) Julien Zuber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hemolysis-associated hemoglobin cast nephropathy results from a range of clinicopathologic disorders

(2019) Zeljko Dvanajscak et al.   KIDNEY INTERNATIONAL

Mechanisms of haemolysis-induced kidney injury

(2019) Kristof Van Avondt et al.   Nature Reviews Nephrology

Hemozoin produced by mammals confers heme tolerance

(2019) Rini H Pek et al.   eLife

Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm

(2019) Michael Hugelshofer et al.   JOURNAL OF CLINICAL INVESTIGATION

Iron homeostasis and oxidative stress: An intimate relationship

(2019) Dimitrios Galaris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors

(2019) Sebastiano Intagliata et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of a haptoglobin-hemoglobin complex in human blood plasma

(2019) Sophia Sarpong-Kumankomah et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human Platelets

(2018) Somanathapura K. NaveenKumar et al.   ACS Chemical Biology

Hemolysis-mediated Toxicity during Cardiopulmonary Bypass Ameliorated by Inhaled Nitric Oxide Gas

(2018) Taijyu Satoh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The macrophage heme-heme oxygenase-1 system and its role in inflammation

(2018) Vijith Vijayan et al.   BIOCHEMICAL PHARMACOLOGY

Structure and function of haemoglobins

(2018) David A. Gell   BLOOD CELLS MOLECULES AND DISEASES

Hemolysis and immune regulation

(2018) Hui Zhong et al.   CURRENT OPINION IN HEMATOLOGY

Thalassaemia

(2018) Ali T Taher et al.   LANCET

Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells

(2018) Judit Erdei et al.   Oxidative Medicine and Cellular Longevity

C3-mediated extravascular hemolysis in PNH on eculizumab: Mechanism and clinical implications

(2018) Rosario Notaro et al.   SEMINARS IN HEMATOLOGY

Redox Functions of Heme Oxygenase-1 and Biliverdin Reductase in Diabetes

(2018) Luc Rochette et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Squeezing for Life – Properties of Red Blood Cell Deformability

(2018) Rick Huisjes et al.   Frontiers in Physiology

Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

(2018) Anthony J. Donato et al.   CIRCULATION RESEARCH

The sinister face of heme oxygenase-1 in brain aging and disease

(2018) Hyman M. Schipper et al.   PROGRESS IN NEUROBIOLOGY

Coupling Between Interleukin-1R1 and Necrosome Complex Involves in Hemin-Induced Neuronal Necroptosis After Intracranial Hemorrhage

(2018) Xiang Chu et al.   STROKE

Ferroptosis and Its Role in Diverse Brain Diseases

(2018) Abigail Weiland et al.   MOLECULAR NEUROBIOLOGY

Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

(2018) Olivia May et al.   Frontiers in Immunology

Characterization of plasma labile heme in hemolytic conditions

(2017) Zélia Gouveia et al.   FEBS Journal

Haemolytic uraemic syndrome

(2017) Fadi Fakhouri et al.   LANCET

From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and Erythrophagocytosis

(2017) Thomas R. L. Klei et al.   Frontiers in Immunology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red CellsClinical Perspective

(2016) Jan A. Graw et al.   CIRCULATION

Red alert: labile heme is an alarmin

(2016) Miguel P Soares et al.   CURRENT OPINION IN IMMUNOLOGY

ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia

(2016) N. Arashiki et al.   HAEMATOLOGICA

Endothelial cells: source, barrier, and target of defensive mediators

(2016) Lubka T. Roumenina et al.   IMMUNOLOGICAL REVIEWS

Red cell DAMPs and inflammation

(2016) Rafaela Mendonça et al.   INFLAMMATION RESEARCH

Thrombin generation and cell-dependent hypercoagulability in sickle cell disease

(2016) M. F. Whelihan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats

(2016) Xinjin Chi et al.   Journal of Translational Medicine

Protein aggregation as a cellular response to oxidative stress induced by heme and iron

(2016) Luiz R. C. Vasconcellos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial cell senescence and thrombosis: Ageing clots

(2016) Magdalena L. Bochenek et al.   THROMBOSIS RESEARCH

Hemin Preconditioning Upregulates Heme Oxygenase-1 in Deceased Donor Renal Transplant Recipients

(2016) Rachel A. B. Thomas et al.   TRANSPLANTATION

Heme: Modulator of Plasma Systems in Hemolytic Diseases

(2016) Lubka T. Roumenina et al.   TRENDS IN MOLECULAR MEDICINE

ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia

(2016) N. Arashiki et al.   HAEMATOLOGICA

Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices

(2016) Joo-Yeun Oh et al.   Redox Biology

Glomerular Diseases Dependent on Complement Activation, Including Atypical Hemolytic Uremic Syndrome, Membranoproliferative Glomerulonephritis, and C3 Glomerulopathy: Core Curriculum 2015

(2015) Marina Noris et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Macrophages and iron trafficking at the birth and death of red cells

(2015) T. Korolnek et al.   BLOOD

Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

(2015) S. M. Camus et al.   BLOOD

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

(2015) F. Vinchi et al.   BLOOD

Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: A translational cross-over study

(2015) Douwe Dekker et al.   Diabetes & Vascular Disease Research

Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia

(2015) W. Barcellini et al.   DISEASE MARKERS

Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex

(2015) Florence Vallelian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity

(2015) Jeremy W. Deuel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Excess of heme induces tissue factor-dependent activation of coagulation in mice

(2015) E. M. Sparkenbaugh et al.   HAEMATOLOGICA

TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells

(2015) Sarah E. Sartain et al.   JOURNAL OF IMMUNOLOGY

Six Months of Hydroxyurea Reduces Albuminuria in Patients with Sickle Cell Disease

(2015) P. Bartolucci et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Heme-albumin: an honorary enzyme

(2015) P Ascenzi et al.   Cell Death & Disease

Excess of heme induces tissue factor-dependent activation of coagulation in mice

(2015) E. M. Sparkenbaugh et al.   HAEMATOLOGICA

Intravascular Hemolysis, Vascular Endothelial Cell Activation and Thrombophilia in Splenectomized Patients with Hemoglobin E/β-Thalassemia Disease

(2014) Vichai Atichartakarn et al.   ACTA HAEMATOLOGICA

Hemolysis is a primary ATP-release mechanism in human erythrocytes

(2014) J. Sikora et al.   BLOOD

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

(2014) G. Chen et al.   BLOOD

Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients

(2014) W. Barcellini et al.   BLOOD

Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1

(2014) Yun-peng Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

β2-glycoprotein I, lipopolysaccharide and endothelial TLR4: Three players in the two hit theory for anti-phospholipid-mediated thrombosis

(2014) Elena Raschi et al.   JOURNAL OF AUTOIMMUNITY

Haptoglobin Genotype-dependent Differences in Macrophage Lysosomal Oxidative Injury

(2014) Rabea Asleh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement Factor B Mutations in Atypical Hemolytic Uremic Syndrome--Disease-Relevant or Benign?

(2014) M. C. Marinozzi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-like receptor 4 and β2 glycoprotein I interaction on endothelial cells

(2014) MO Borghi et al.   LUPUS

Syndromes of Thrombotic Microangiopathy

(2014) James N. George et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hemolysis-induced lethality involves inflammasome activation by heme

(2014) Fabianno F. Dutra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Like iron in the blood of the people: the requirement for heme trafficking in iron metabolism

(2014) Tamara Korolnek et al.   Frontiers in Pharmacology

Heme on innate immunity and inflammation

(2014) Fabianno F. Dutra et al.   Frontiers in Pharmacology

Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development

(2014) Dominik J. Schaer et al.   Frontiers in Physiology

Of macrophages and red blood cells; a complex love story

(2014) Djuna Z. de Back et al.   Frontiers in Physiology

Heme Oxygenase-1 As a Target for Drug Discovery

(2013) Roberto Motterlini et al.   ANTIOXIDANTS & REDOX SIGNALING

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

(2013) M. Frimat et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease

(2013) Olufolake A. Adisa et al.   BRITISH JOURNAL OF HAEMATOLOGY

HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis

(2013) Carine White et al.   Cell Metabolism

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

(2013) Francesca Vinchi et al.   CIRCULATION

The Identification of Nitric Oxide as Endothelium-Derived Relaxing Factor

(2013) Joseph Loscalzo   CIRCULATION RESEARCH

Genetics and Outcome of Atypical Hemolytic Uremic Syndrome: A Nationwide French Series Comparing Children and Adults

(2013) V. Fremeaux-Bacchi et al.   Clinical Journal of the American Society of Nephrology

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Premature Atherosclerosis in Children With β-Thalassemia Major

(2013) Orhan Gursel et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Combined Complement Gene Mutations in Atypical Hemolytic Uremic Syndrome Influence Clinical Phenotype

(2013) E. Bresin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hematologic Manifestations of Liver Disease

(2013) Peter W. Marks   SEMINARS IN HEMATOLOGY

Atypical Hemolytic Uremic Syndrome

(2013) David Kavanagh et al.   SEMINARS IN NEPHROLOGY

Pathological Conditions Involving Extracellular Hemoglobin: Molecular Mechanisms, Clinical Significance, and Novel Therapeutic Opportunities for α1-Microglobulin

(2012) Magnus G. Olsson et al.   ANTIOXIDANTS & REDOX SIGNALING

A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

(2012) L. T. Roumenina et al.   BLOOD

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

From perpetual haemosiderinuria to possible iron overload: iron redistribution in paroxysmal nocturnal haemoglobinuria patients on eculizumab by magnetic resonance imaging

(2012) Antonio M. Risitano et al.   BRITISH JOURNAL OF HAEMATOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

(2012) Y. Gottlieb et al.   HAEMATOLOGICA

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

(2012) Jin Hyen Baek et al.   JOURNAL OF CLINICAL INVESTIGATION

Heme binds to factor VIII and inhibits its interaction with activated factor IX

(2012) Y. REPESSÉ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Nitric oxide, hemolysis, and the red blood cell storage lesion: interactions between transfusion, donor, and recipient

(2012) Tamir Kanias et al.   TRANSFUSION

Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular Thrombosis

(2011) M. Morigi et al.   JOURNAL OF IMMUNOLOGY

Structural analysis of heme proteins: implications for design and prediction

(2011) Ting Li et al.   BMC STRUCTURAL BIOLOGY

The Redox Activity of Hemoglobins: From Physiologic Functions to Pathologic Mechanisms

(2010) Brandon J. Reeder   ANTIOXIDANTS & REDOX SIGNALING

Haem arginate infusion stimulates haem oxygenase-1 expression in healthy subjects

(2010) D Doberer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease

(2010) John D. Belcher et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Human Heme Oxygenase-1 Deficiency Presenting With Hemolysis, Nephritis, and Asplenia

(2010) Nita Radhakrishnan et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Detrimental effects of adenosine signaling in sickle cell disease

(2010) Yujin Zhang et al.   NATURE MEDICINE

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

(2009) P. W. Buehler et al.   BLOOD

Targeting Heme Oxygenase

(2009) Stephen J. Peterson et al.   Cardiology in Review

First-in-Human Study Demonstrating Pharmacological Activation of Heme Oxygenase-1 in Humans

(2009) A E Bharucha et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Heme Oxygenase-2 Deletion Causes Endothelial Cell Activation Marked by Oxidative Stress, Inflammation, and Angiogenesis

(2009) L. Bellner et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress

(2008) Dhananjay K. Kaul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis

(2008) Krisztina Horváth et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Exacerbated corneal inflammation and neovascularization in the HO-2 null mice is ameliorated by biliverdin

(2008) Lars Bellner et al.   EXPERIMENTAL EYE RESEARCH

Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia

(2008) B. N. Y. SETTY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hormesis defined

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS