Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

(2013) A. George et al.   BLOOD

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

(2013) Francesca Vinchi et al.   CIRCULATION

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Molecular Link between Intravascular Hemolysis and Vascular Occlusion in Sickle Cell Disease

(2012) Zhou Zhou et al.   Current Vascular Pharmacology

Functional architecture of Weibel-Palade bodies

(2011) K. M. Valentijn et al.   BLOOD

The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma

(2011) J. Chen et al.   BLOOD

Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction

(2011) Madelyn S. Hanson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis

(2011) Mark T. Gladwin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

(2010) R. P. Hebbel et al.   BLOOD

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

(2010) D. R. Kohli et al.   BLOOD

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Heme Scavenging and the Other Facets of Hemopexin

(2009) Emanuela Tolosano et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme Degradation and Vascular Injury

(2009) John D. Belcher et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme–Hemopexin Complex Attenuates Neuronal Cell Death and Stroke Damage

(2009) Rung-chi Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Fibronectin bridges monocytes and reticulocytes via integrin α4β1

(2008) Julia E. Brittain et al.   BRITISH JOURNAL OF HAEMATOLOGY