Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm

Cognitive impairment, functional outcome and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

(2019) Matthew E. Eagles et al.   World Neurosurgery

Propentdyopents as Heme Degradation Intermediates Constrict Mouse Cerebral Arterioles and Are Present in the Cerebrospinal Fluid of Patients With Subarachnoid Hemorrhage

(2019) Alexander Joerk et al.   CIRCULATION RESEARCH

Estimating the Global Incidence of Aneurysmal Subarachnoid Hemorrhage: A Systematic Review for Central Nervous System Vascular Lesions and Meta-Analysis of Ruptured Aneurysms

(2018) Joshua D. Hughes et al.   World Neurosurgery

Neuroinflammation as a Target for Intervention in Subarachnoid Hemorrhage

(2018) Airton Leonardo de Oliveira Manoel et al.   Frontiers in Neurology

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

(2018) John D. Belcher et al.   PLoS One

Cell-Free Oxyhemoglobin in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage: Biomarker and Potential Therapeutic Target

(2018) Michael Hugelshofer et al.   World Neurosurgery

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

To Improve Translational Research in Subarachnoid Hemorrhage

(2017) Hidenori Suzuki et al.   Translational Stroke Research

Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis

(2016) Christian A. Schaer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red CellsClinical Perspective

(2016) Jan A. Graw et al.   CIRCULATION

Nitric oxide inhalation reduces brain damage, prevents mortality, and improves neurological outcome after subarachnoid hemorrhage by resolving early pial microvasospasms

(2016) Nicole A Terpolilli et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study

(2016) Angelika Ehlert et al.   JOURNAL OF NEUROSURGERY

A Case of Hyperacute Onset of Vasospasm After Aneurysmal Subarachnoid Hemorrhage and Refractory Vasospasm Treated with Intravenous and Intraventricular Nitric Oxide: A Mini Review

(2016) Angelika Ehlert et al.   World Neurosurgery

The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside

(2015) P.S. Garry et al.   EXPERIMENTAL NEUROLOGY

Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex

(2015) Florence Vallelian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity

(2015) Jeremy W. Deuel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Outer brain barriers in rat and human development

(2015) Christian B. Brøchner et al.   Frontiers in Neuroscience

Extracellular Hb Enhances Cardiac Toxicity in Endotoxemic Guinea Pigs: Protective Role of Haptoglobin

(2014) Jin Baek et al.   Toxins

Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development

(2014) Dominik J. Schaer et al.   Frontiers in Physiology

Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine β145

(2013) Chris E. Cooper et al.   ANTIOXIDANTS & REDOX SIGNALING

Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity

(2013) Miriam Lipiski et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage

(2013) C A Schaer et al.   CELL DEATH AND DIFFERENTIATION

European Stroke Organization Guidelines for the Management of Intracranial Aneurysms and Subarachnoid Haemorrhage

(2013) Thorsten Steiner et al.   CEREBROVASCULAR DISEASES

Endothelial nitric oxide: protector of a healthy mind

(2013) Z. S. Katusic et al.   EUROPEAN HEART JOURNAL

Dissociation of vasospasm-related morbidity and outcomes in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: a meta-analysis of randomized controlled trials

(2013) Jian Shen et al.   JOURNAL OF NEUROSURGERY

Safety and pharmacokinetics of sodium nitrite in patients with subarachnoid hemorrhage: a Phase IIA study

(2013) Edward H. Oldfield et al.   JOURNAL OF NEUROSURGERY

Delayed neurological deterioration after subarachnoid haemorrhage

(2013) R. Loch Macdonald   Nature Reviews Neurology

The Epidemiology of Admissions of Nontraumatic Subarachnoid Hemorrhage in the United States

(2013) Fred Rincon et al.   NEUROSURGERY

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

(2012) Jin Hyen Baek et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease

(2012) Mark T. Gladwin et al.   JOURNAL OF CLINICAL INVESTIGATION

The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage

(2012) James Galea et al.   JOURNAL OF NEUROCHEMISTRY

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Mechanisms of microthrombi formation after experimental subarachnoid hemorrhage

(2012) M. Sabri et al.   NEUROSCIENCE

The importance of early brain injury after subarachnoid hemorrhage

(2012) Fatima A. Sehba et al.   PROGRESS IN NEUROBIOLOGY

Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage

(2012) E. Sander Connolly et al.   STROKE

Sodium nitrite induces acute central nervous system toxicity in guinea pigs exposed to systemic cell-free hemoglobin

(2011) Paul W. Buehler et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity

(2011) Yipin Zhou et al.   BIOTECHNOLOGY PROGRESS

Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

(2011) Chenell Donadee et al.   CIRCULATION

Role of Endothelial Nitric Oxide in Cerebrovascular Regulation

(2011) Dmitriy N. Atochin et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Reversal of cerebral vasospasm via intravenous sodium nitrite after subarachnoid hemorrhage in primates

(2011) Ali Reza Fathi et al.   JOURNAL OF NEUROSURGERY

Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2)

(2011) R Loch Macdonald et al.   LANCET NEUROLOGY

How Large Is the Typical Subarachnoid Hemorrhage? A Review of Current Neurosurgical Knowledge

(2011) Robert G. Whitmore et al.   World Neurosurgery

Quantitative Mass Spectrometry Defines an Oxidative Hotspot in Hemoglobin that is Specifically Protected by Haptoglobin

(2010) Tatiana Pimenova et al.   JOURNAL OF PROTEOME RESEARCH

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Purification of hemoglobin by tangential flow filtration with diafiltration

(2009) Jacob Elmer et al.   BIOTECHNOLOGY PROGRESS

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

(2009) P. W. Buehler et al.   BLOOD

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

(2009) Felicitas S. Boretti et al.   JOURNAL OF CLINICAL INVESTIGATION

Subarachnoid hemorrhage and the distribution of drugs delivered into the cerebrospinal fluid

(2009) Ryszard M. Pluta et al.   JOURNAL OF NEUROSURGERY

Characterization of high molecular weight multimeric states of human haptoglobin and hemoglobin-based oxygen carriers by high-mass MALDI MS

(2009) Tatiana Pimenova et al.   JOURNAL OF SEPARATION SCIENCE

Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought

(2009) Ryszard M. Pluta et al.   NEUROLOGICAL RESEARCH

Oxyhemoglobin-Induced Expression of R-Type Ca 2+ Channels in Cerebral Arteries

(2008) Timothy E. Link et al.   STROKE

Nitric Oxide Modulates Spreading Depolarization Threshold in the Human and Rodent Cortex

(2008) Gabor C. Petzold et al.   STROKE