Characterization of plasma labile heme in hemolytic conditions

Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

(2016) Catarina Cunha-Santos et al.   AIDS

Red alert: labile heme is an alarmin

(2016) Miguel P Soares et al.   CURRENT OPINION IN IMMUNOLOGY

Macrophages and Iron Metabolism

(2016) Miguel P. Soares et al.   IMMUNITY

Regulation of intracellular heme trafficking revealed by subcellular reporters

(2016) Xiaojing Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors

(2016) David A. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme: Modulator of Plasma Systems in Hemolytic Diseases

(2016) Lubka T. Roumenina et al.   TRENDS IN MOLECULAR MEDICINE

Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase-1

(2016) Tigist Kassa et al.   FEBS Open Bio

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

(2015) F. Vinchi et al.   BLOOD

The Iron age of host-microbe interactions

(2015) M. P. Soares et al.   EMBO REPORTS

Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders

(2015) Ann Smith et al.   Frontiers in Physiology

Hemolysis-induced lethality involves inflammasome activation by heme

(2014) Fabianno F. Dutra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Disease Tolerance to Malaria by Nitric Oxide and Carbon Monoxide

(2014) Viktória Jeney et al.   Cell Reports

Coupling Heme and Iron Metabolism via Ferritin H Chain

(2013) Raffaella Gozzelino et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis

(2013) Carine White et al.   Cell Metabolism

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

(2013) Francesca Vinchi et al.   CIRCULATION

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Metabolic Adaptation to Tissue Iron Overload Confers Tolerance to Malaria

(2012) Raffaella Gozzelino et al.   Cell Host & Microbe

Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

(2012) Rasmus Larsen et al.   Frontiers in Pharmacology

Sickle Hemoglobin Confers Tolerance to Plasmodium Infection

(2011) Ana Ferreira et al.   CELL

Structural analysis of heme proteins: implications for design and prediction

(2011) Ting Li et al.   BMC STRUCTURAL BIOLOGY

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Heme Amplifies the Innate Immune Response to Microbial Molecules through Spleen Tyrosine Kinase (Syk)-dependent Reactive Oxygen Species Generation

(2010) Patricia L. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The therapeutic potential of carbon monoxide

(2010) Roberto Motterlini et al.   NATURE REVIEWS DRUG DISCOVERY

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Trafficking of Heme and Porphyrins in Metazoa

(2009) Scott Severance et al.   CHEMICAL REVIEWS

Heme–Hemopexin Complex Attenuates Neuronal Cell Death and Stroke Damage

(2009) Rung-chi Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Structural analysis of lipocalin-type prostaglandin D synthase complexed with biliverdin by small-angle X-ray scattering and multi-dimensional NMR

(2009) Yuya Miyamoto et al.   JOURNAL OF STRUCTURAL BIOLOGY

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

(2009) E. Seixas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Regulator RcoM-2 fromBurkholderia xenovoransIs a Cysteine-Ligated Hemoprotein That Undergoes a Redox-Mediated Ligand Switch†

(2008) Katherine A. Marvin et al.   BIOCHEMISTRY

Role for copper in the cellular and regulatory effects of heme-hemopexin

(2008) Ann Smith et al.   BIOMETALS

A central role for free heme in the pathogenesis of severe malaria: the missing link?

(2008) Ana Ferreira et al.   JOURNAL OF MOLECULAR MEDICINE-JMM