Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism

(2012) Paul W. Buehler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary Hypertension in Lambs Transfused with Stored Blood Is Prevented by Breathing Nitric Oxide

(2012) David M. Baron et al.   ANESTHESIOLOGY

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

(2012) G. B. Fortes et al.   BLOOD

Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions

(2012) Sambuddha Banerjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

The effect of hemolysis on plasma oxidation and nitration in patients with sickle cell disease

(2012) Alphan Kupesiz et al.   FREE RADICAL RESEARCH

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

(2012) Jin Hyen Baek et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Hemopexin as an Anti-Inflammatory Factor That Inhibits Synergy of Hemoglobin with HMGB1 in Sterile and Infectious Inflammation

(2012) T. Lin et al.   JOURNAL OF IMMUNOLOGY

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

(2012) Sen Lin et al.   Journal of Neuroinflammation

Cationic Porphyrins Are Reversible Proteasome Inhibitors

(2012) Anna Maria Santoro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Increased Expression of Oxidation-Specific Epitopes and Apoptosis Are Associated With Haptoglobin Genotype

(2012) K-Raman Purushothaman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice

(2012) Binglan Yu et al.   TRANSFUSION

Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron

(2011) E. A. Hod et al.   BLOOD

Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction

(2011) Madelyn S. Hanson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

(2011) Chenell Donadee et al.   CIRCULATION

Pulmonary hypertension diagnosed by right heart catheterisation in sickle cell disease

(2011) G. H. H. Fonseca et al.   EUROPEAN RESPIRATORY JOURNAL

A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease

(2011) Florence Parent et al.   NEW ENGLAND JOURNAL OF MEDICINE

An alternative view of the proposed alternative activities of hemopexin

(2011) Marcia R. Mauk et al.   PROTEIN SCIENCE

Transfusion of older stored blood and risk of death: a meta-analysis

(2011) Dong Wang et al.   TRANSFUSION

Reconstructing sickle cell disease: A data-based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence-based medicine

(2010) Robert P. Hebbel   AMERICAN JOURNAL OF HEMATOLOGY

Inhibition of Neutrophil Migration by Hemopexin Leads to Increased Mortality Due to Sepsis in Mice

(2010) Fernando Spiller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Redox Activity of Hemoglobins: From Physiologic Functions to Pathologic Mechanisms

(2010) Brandon J. Reeder   ANTIOXIDANTS & REDOX SIGNALING

Red Cells, Hemoglobin, Heme, Iron, and Atherogenesis

(2010) Emőke Nagy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pulmonary hypertension and nitric oxide depletion in sickle cell disease

(2010) H. F. Bunn et al.   BLOOD

Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity

(2010) F. Vallelian et al.   BLOOD

Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

(2010) E. A. Hod et al.   BLOOD

Is prophylactic haptoglobin infusion in peripheral blood stem cell transplantation clinically useful?

(2010) Hiroyuki Tsuda et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Synergistic Inflammation Is Induced by Blood Degradation Products with Microbial Toll‐Like Receptor Agonists and Is Blocked by Hemopexin

(2010) Tian Lin et al.   JOURNAL OF INFECTIOUS DISEASES

Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease

(2010) John D. Belcher et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Quantitative Mass Spectrometry Defines an Oxidative Hotspot in Hemoglobin that is Specifically Protected by Haptoglobin

(2010) Tatiana Pimenova et al.   JOURNAL OF PROTEOME RESEARCH

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design

(2010) Paul W. Buehler et al.   TRENDS IN MOLECULAR MEDICINE

Heme Scavenging and the Other Facets of Hemopexin

(2009) Emanuela Tolosano et al.   ANTIOXIDANTS & REDOX SIGNALING

Haptoglobin: Basic and Clinical Aspects

(2009) Andrew P. Levy et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme Degradation and Vascular Injury

(2009) John D. Belcher et al.   ANTIOXIDANTS & REDOX SIGNALING

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

(2009) P. W. Buehler et al.   BLOOD

Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages

(2009) Xueya Liang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload

(2008) Francesca Vinchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Structural Stabilization in Tetrameric or Polymeric Hemoglobin Determines Its Interaction with Endogenous Antioxidant Scavenger Pathways

(2008) Paul W. Buehler et al.   ANTIOXIDANTS & REDOX SIGNALING

Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease

(2008) S. Yuditskaya et al.   BLOOD

The reaction of hydrogen peroxide with hemoglobin induces extensive α-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways

(2008) Florence Vallelian et al.   FREE RADICAL BIOLOGY AND MEDICINE