Extracellular hemin crisis triggers acute chest syndrome in sickle mice

Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients

(2013) G. Galarneau et al.   BLOOD

Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease

(2013) Olufolake A. Adisa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Blood gases and energy metabolites in mouse blood before and after cerebral ischemia: the effects of anesthetics

(2013) Tina M Schwarzkopf et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The acute chest syndrome of sickle cell disease

(2013) Payal C Desai et al.   EXPERT OPINION ON PHARMACOTHERAPY

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis study failure highlights need for trial design rethink

(2013) Man Tsuey Tse   NATURE REVIEWS DRUG DISCOVERY

Antisickling fetal hemoglobin reduces hypoxia-inducible factor-1α expression in normoxic sickle mice: microvascular implications

(2012) Dhananjay K. Kaul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease

(2012) C. J. Bean et al.   BLOOD

ShRNA-Targeted COMMD7 Suppresses Hepatocellular Carcinoma Growth

(2012) Lu Zheng et al.   PLoS One

Hospital volume, hospital teaching status, patient socioeconomic status, and outcomes in patients hospitalized with sickle cell disease

(2011) Timothy L. McCavit et al.   AMERICAN JOURNAL OF HEMATOLOGY

Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction

(2011) Madelyn S. Hanson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Global Gene Expression Profiling of Endothelium Exposed to Heme Reveals an Organ-Specific Induction of Cytoprotective Enzymes in Sickle Cell Disease

(2011) Samit Ghosh et al.   PLoS One

Reconstructing sickle cell disease: A data-based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence-based medicine

(2010) Robert P. Hebbel   AMERICAN JOURNAL OF HEMATOLOGY

Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease

(2010) K. L. Wallace et al.   BLOOD

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-  and CXCR3 chemokines

(2009) K. L. Wallace et al.   BLOOD

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

(2009) K Takashima et al.   BRITISH JOURNAL OF PHARMACOLOGY

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury

(2009) Mark R. Looney et al.   JOURNAL OF CLINICAL INVESTIGATION

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

(2009) E. Seixas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection

(2009) David Verhoeven et al.   VIROLOGY

Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload

(2008) Francesca Vinchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Animal models of acute lung injury

(2008) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary Complications of Sickle Cell Disease

(2008) Mark T. Gladwin et al.   NEW ENGLAND JOURNAL OF MEDICINE