P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

Experimental confirmation of the C3 tickover hypothesis by studies with an Ab (S77) that inhibits tickover in whole serum

(2018) Peter J. Lachmann et al.   FASEB JOURNAL

Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis

(2018) Nicolas S. Merle et al.   Frontiers in Immunology

Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

(2018) Olivia May et al.   Frontiers in Immunology

Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease

(2017) Kenneth I. Ataga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia

(2016) Margaret A. Lindorfer et al.   CLINICAL IMMUNOLOGY

Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis

(2016) X. Ariza et al.   JOURNAL OF HEPATOLOGY

Von Willebrand factor regulates complement on endothelial cells

(2016) Damien G. Noone et al.   KIDNEY INTERNATIONAL

Heme: Modulator of Plasma Systems in Hemolytic Diseases

(2016) Lubka T. Roumenina et al.   TRENDS IN MOLECULAR MEDICINE

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

(2015) F. Vinchi et al.   BLOOD

Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity

(2015) Jeremy W. Deuel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6/STAT3

(2015) Ming-Jiang Xu et al.   HEPATOLOGY

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

von Willebrand factor is a cofactor in complement regulation

(2014) S. Feng et al.   BLOOD

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

(2014) G. Chen et al.   BLOOD

Heme on innate immunity and inflammation

(2014) Fabianno F. Dutra et al.   Frontiers in Pharmacology

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

(2013) M. Frimat et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Identification of a Novel Mode of Complement Activation on Stimulated Platelets Mediated by Properdin and C3(H2O)

(2013) G. Saggu et al.   JOURNAL OF IMMUNOLOGY

A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia

(2012) Madelyn S. Hanson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Identification of Hemopexin as an Anti-Inflammatory Factor That Inhibits Synergy of Hemoglobin with HMGB1 in Sterile and Infectious Inflammation

(2012) T. Lin et al.   JOURNAL OF IMMUNOLOGY

The CD46-Jagged1 interaction is critical for human TH1 immunity

(2012) Gaëlle Le Friec et al.   NATURE IMMUNOLOGY

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

(2011) Chenell Donadee et al.   CIRCULATION

Heme Interacts with C1q and Inhibits the Classical Complement Pathway

(2011) Lubka T. Roumenina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular Thrombosis

(2011) M. Morigi et al.   JOURNAL OF IMMUNOLOGY

P-Selectin–Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease

(2010) Renata Polanowska-Grabowska et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver

(2010) Kumaravelu Jagavelu et al.   HEPATOLOGY

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Anemia upregulates lipocalin 2 in the liver and serum

(2008) Wenlei Jiang et al.   BLOOD CELLS MOLECULES AND DISEASES

Regulated complement deposition on the surface of human endothelial cells: Effect of tobacco smoke and shear stress

(2008) Wei Yin et al.   THROMBOSIS RESEARCH