A mechanistic integrative computational model of macrophage polarization: Implications in human pathophysiology

Antiangiogenic VEGF 165 b Regulates Macrophage Polarization via S100A8/S100A9 in Peripheral Artery Disease

(2019) Vijay Chaitanya Ganta et al.   CIRCULATION

Mechanistic Computational Models of MicroRNA-Mediated Signaling Networks in Human Diseases

(2019) Chen Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL-1β and TNFα Differentially Influence NF-κB Activity and FasL-Induced Apoptosis in Primary Murine Hepatocytes During LPS-Induced Inflammation

(2019) Julia Rex et al.   Frontiers in Physiology

Mapping macrophage polarization over the myocardial infarction time continuum

(2018) Alan J. Mouton et al.   BASIC RESEARCH IN CARDIOLOGY

PPARγ is a nexus controlling alternative activation of macrophages via glutamine metabolism

(2018) Victoria L. Nelson et al.   GENES & DEVELOPMENT

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

(2018) Amy T. Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid cell contributions to cardiovascular health and disease

(2018) Matthias Nahrendorf   NATURE MEDICINE

Interventions for lower extremity peripheral artery disease

(2018) Jade S. Hiramoto et al.   Nature Reviews Cardiology

VEGF may contribute to macrophage recruitment and M2 polarization in the decidua

(2018) Karen C. Wheeler et al.   PLoS One

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

(2018) Qirui Wang et al.   Nature Communications

A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens

(2018) Mehdi Bouhaddou et al.   PLoS Computational Biology

Metabolic Modulation in Macrophage Effector Function

(2018) Ciana Diskin et al.   Frontiers in Immunology

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment

(2018) Grace Mahlbacher et al.   Journal for ImmunoTherapy of Cancer

Targeting Macrophages in Cancer: From Bench to Bedside

(2018) Ashleigh R. Poh et al.   Frontiers in Oncology

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Transcriptional profiling identifies novel regulators of macrophage polarization

(2018) Kimberline Y. Gerrick et al.   PLoS One

Gene Regulatory Network Modeling of Macrophage Differentiation Corroborates the Continuum Hypothesis of Polarization States

(2018) Alessandro Palma et al.   Frontiers in Physiology

Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model

(2018) Fabian Fröhlich et al.   Cell Systems

Current prospects of type II interferon γ signaling and autoimmunity

(2017) Daniel S. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells

(2017) Daniel Yee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro

(2017) Hiromi Shiratori et al.   MOLECULAR IMMUNOLOGY

The Encyclopedia of Proteome Dynamics: a big data ecosystem for (prote)omics

(2017) Alejandro Brenes et al.   NUCLEIC ACIDS RESEARCH

Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model

(2017) Chen Zhao et al.   PLoS Computational Biology

PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy

(2017) Sha Gao et al.   Scientific Reports

A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFNγ

(2017) Ji Eun Lim et al.   Scientific Reports

Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarction

(2016) Merry L. Lindsey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Statistical ensemble of gene regulatory networks of macrophage differentiation

(2016) Filippo Castiglione et al.   BMC BIOINFORMATICS

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

(2016) Evanna L. Mills et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Regulation of macrophage polarization and plasticity by complex activation signals

(2016) Tim D. Smith et al.   Integrative Biology

Suppressor of Cytokine Signaling (SOCS)1 Regulates Interleukin-4 (IL-4)-activated Insulin Receptor Substrate (IRS)-2 Tyrosine Phosphorylation in Monocytes and Macrophages via the Proteasome

(2016) Sarah M. McCormick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

(2016) Aravind Tallam et al.   PLoS One

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

(2016) Tetsuya Kimura et al.   Nature Communications

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection

(2016) Ulrike Schleicher et al.   Cell Reports

Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages

(2016) Julia Rex et al.   PLoS Computational Biology

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

(2016) Jan Naujoks et al.   PLoS Pathogens

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

Comparative evaluation ofin vitrohuman macrophage models for mycobacterial infection study

(2016) E. Mendoza-Coronel et al.   Pathogens and Disease

HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development

(2016) Zhaoliang Su et al.   Scientific Reports

Bioanalytical chemistry of cytokines – A review

(2015) Julie A. Stenken et al.   ANALYTICA CHIMICA ACTA

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

(2015) Marie Genin et al.   BMC CANCER

Targeting IL4/IL4R for the treatment of epithelial cancer metastasis

(2015) Katherine Venmar Bankaitis et al.   CLINICAL & EXPERIMENTAL METASTASIS

Essential role of endocytosis for interleukin-4-receptor-mediated JAK/STAT signalling

(2015) K. Kurgonaite et al.   JOURNAL OF CELL SCIENCE

Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons

(2015) Isabella Rauch et al.   MOLECULAR AND CELLULAR BIOLOGY

Synchronous down-modulation of miR-17 family members is an early causative event in the retinal angiogenic switch

(2015) Diana N. Nunes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The synergistic interaction between the calcineurin B subunit and IFN-γ enhances macrophage antitumor activity

(2015) Z Su et al.   Cell Death & Disease

Temporal regulation of HIF-1 and NF-κB in hypoxic hepatocarcinoma cells

(2015) Yuan Jiang et al.   Oncotarget

Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer

(2015) Chen Zhao et al.   PLoS Computational Biology

Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype

(2015) Igor Malyshev et al.   Biomed Research International

Cell-Type-Resolved Quantitative Proteomics of Murine Liver

(2014) S. Babak Azimifar et al.   Cell Metabolism

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization

(2014) Dipali Date et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFN- -Induced TNF-  Expression Is Regulated by Interferon Regulatory Factors 1 and 8 in Mouse Macrophages

(2014) V. Vila-del Sol et al.   JOURNAL OF IMMUNOLOGY

IFN-γ Primes Macrophage Activation by Increasing Phosphatase and Tensin Homolog via Downregulation of miR-3473b

(2014) Cong Wu et al.   JOURNAL OF IMMUNOLOGY

Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease

(2014) Eric Olson et al.   VASCULAR MEDICINE

SOCS Proteins in Macrophage Polarization and Function

(2014) Heather M. Wilson   Frontiers in Immunology

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

“Of Mice and Men”: Arginine Metabolism in Macrophages

(2014) Anita C. Thomas et al.   Frontiers in Immunology

Myeloid Colony-Stimulating Factors as Regulators of Macrophage Polarization

(2014) Thomas A. Hamilton et al.   Frontiers in Immunology

Mathematical Modeling of Pro- and Anti-Inflammatory Signaling in Macrophages

(2014) Shreya Maiti et al.   Processes

Transcriptional Control of Macrophage Polarization

(2013) Derin Tugal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA-93 Controls Perfusion Recovery After Hindlimb Ischemia by Modulating Expression of Multiple Genes in the Cell Cycle Pathway

(2013) Surovi Hazarika et al.   CIRCULATION

Parameter uncertainty in biochemical models described by ordinary differential equations

(2013) J. Vanlier et al.   MATHEMATICAL BIOSCIENCES

Interleukin-4-induced β-catenin regulates the conversion of macrophages to multinucleated giant cells

(2013) Flora Binder et al.   MOLECULAR IMMUNOLOGY

Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD

(2013) D Ortiz-Masiá et al.   Mucosal Immunology

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Mathematical modeling and stability analysis of macrophage activation in left ventricular remodeling post-myocardial infarction

(2012) Yunji Wang et al.   BMC GENOMICS

Tumor Necrosis Factor-α Signaling in Macrophages

(2012) Narayanan Parameswaran et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Hypoxia-mediated regulation of macrophage functions in pathophysiology

(2012) Elena Riboldi et al.   INTERNATIONAL IMMUNOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of JAKs in Macrophages Increases Lipopolysaccharide-Induced Cytokine Production by Blocking IL-10-Mediated Feedback

(2012) M. J. Pattison et al.   JOURNAL OF IMMUNOLOGY

SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation

(2012) H. Qin et al.   JOURNAL OF IMMUNOLOGY

Role of MAP Kinases and PI3K-Akt on the cytokine inflammatory profile of peritoneal macrophages from the ascites of cirrhotic patients

(2012) Ana Tapia-Abellán et al.   LIVER INTERNATIONAL

Effect of Hypoxia-Inducible Factor-1α Gene Therapy on Walking Performance in Patients With Intermittent Claudication

(2011) Mark A. Creager et al.   CIRCULATION

Alternative activation of macrophages by IL-4 requires SHIP degradation

(2011) Shelley B. Weisser et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systems-wide Proteomic Analysis in Mammalian Cells Reveals Conserved, Functional Protein Turnover

(2011) Sidney B. Cambridge et al.   JOURNAL OF PROTEOME RESEARCH

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Molecular mechanisms regulating macrophage response to hypoxia

(2011) Michal A. Rahat   Frontiers in Immunology

Control of Macrophage Activation and Function by PPARs

(2010) Ajay Chawla   CIRCULATION RESEARCH

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

(2010) Attila Szanto et al.   IMMUNITY

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in Macrophages

(2010) S. S. Iyer et al.   JOURNAL OF IMMUNOLOGY

Toward a system-level understanding of microRNA pathway via mathematical modeling

(2009) Xia Wang et al.   BIOSYSTEMS

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

(2009) Xiaoyu Hu et al.   IMMUNOLOGICAL REVIEWS

Lipopolysaccharide-driven Th2 Cytokine Production in Macrophages Is Regulated by Both MyD88 and TRAM

(2009) Sumanta Mukherjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Oxygen Sensing Modulates Antigen Presentation and Phagocytic Functions Involving IFN-  Production through the HIF-1  Transcription Factor

(2009) B. Acosta-Iborra et al.   JOURNAL OF IMMUNOLOGY

Autocrine IL-10 Induces Hallmarks of Alternative Activation in Macrophages and Suppresses Antituberculosis Effector Mechanisms without Compromising T Cell Immunity

(2009) T. Schreiber et al.   JOURNAL OF IMMUNOLOGY

IRF-1 Promotes Inflammation Early after Ischemic Acute Kidney Injury

(2009) Y. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Concerted Kinase Interplay Identifies PPARγ as a Molecular Target of Ghrelin Signaling in Macrophages

(2009) Annie Demers et al.   PLoS One

SOCS1 and SOCS3 in the control of CNS immunity

(2009) Brandi J. Baker et al.   TRENDS IN IMMUNOLOGY

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL

Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells

(2008) L. V. Sharova et al.   DNA RESEARCH

Macrophage roles following myocardial infarction

(2008) Jessica M. Lambert et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

IFN-γ synergizes with LPS to induce nitric oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10

(2008) Chiou-Feng Lin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A methodology for performing global uncertainty and sensitivity analysis in systems biology

(2008) Simeone Marino et al.   JOURNAL OF THEORETICAL BIOLOGY

Reactive Oxygen Species Regulate Hypoxia-Inducible Factor 1  Differentially in Cancer and Ischemia

(2008) A. A. Qutub et al.   MOLECULAR AND CELLULAR BIOLOGY

SOCS regulation of the JAK/STAT signalling pathway

(2008) Ben A. Croker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY