Targeting IL4/IL4R for the treatment of epithelial cancer metastasis

IL4 receptor α mediates enhanced glucose and glutamine metabolism to support breast cancer growth

(2015) Katherine T. Venmar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Dynamics and Interaction of Interleukin-4 Receptor Subunits in Living Cells

(2014) Hetvi Gandhi et al.   BIOPHYSICAL JOURNAL

Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor

(2014) Ann M Leen et al.   MOLECULAR THERAPY

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

(2014) Lisa A. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL4 Limits the Efficacy of Tumor-Targeted Antibody Therapy in a Murine Model

(2014) R. Surana et al.   Cancer Immunology Research

IL-4 Analogues with Site-Specific Chemical Modification at Position 121 Inhibit IL-4 and IL-13 Biological Activities

(2013) Viswanadham Duppatla et al.   BIOCONJUGATE CHEMISTRY

Therapeutic modulators of STAT signalling for human diseases

(2013) Gabriella Miklossy et al.   NATURE REVIEWS DRUG DISCOVERY

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Interleukin-4 in Asthma: Lost in Translation?

(2012) Tania Maes et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Aptamer-Mediated Blockade of IL4R  Triggers Apoptosis of MDSCs and Limits Tumor Progression

(2012) F. Roth et al.   CANCER RESEARCH

Cytokine Stimulation of Epithelial Cancer Cells: The Similar and Divergent Functions of IL-4 and IL-13

(2012) M. A. Hallett et al.   CANCER RESEARCH

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

(2012) Ilkka S Junttila et al.   Nature Chemical Biology

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

Targeting interleukins to treat severe asthma

(2012) David Gibeon et al.   Expert Review of Respiratory Medicine

Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13

(2011) Rachel F. Gabitass et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Alternative activation of tumor-associated macrophages by IL-4

(2011) Hao-Wei Wang et al.   CELL CYCLE

Ruxolitinib: a new JAK1/2 inhibitor that offers promising options for treatment of myelofibrosis

(2011) Alen Ostojic et al.   Future Oncology

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Airway Wall Expression of OX40/OX40L and Interleukin-4 in Asthma

(2010) Salman Siddiqui et al.   CHEST

Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells

(2010) N. I. OBIRI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Distinct Structural Requirements for Interleukin-4 (IL-4) and IL-13 Binding to the Shared IL-13 Receptor Facilitate Cellular Tuning of Cytokine Responsiveness

(2009) Takachika Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells

(2008) Ben Hui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-13 as a therapeutic target for respiratory disease

(2008) Marion T. Kasaian et al.   BIOCHEMICAL PHARMACOLOGY

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4

(2008) M Todaro et al.   CELL DEATH AND DIFFERENTIATION

Interleukin-4, Interleukin-13, Signal Transducer and Activator of Transcription Factor 6, and Allergic Asthma

(2008) Douglas Kuperman et al.   CURRENT MOLECULAR MEDICINE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark