Suppressor of Cytokine Signaling (SOCS)1 Regulates Interleukin-4 (IL-4)-activated Insulin Receptor Substrate (IRS)-2 Tyrosine Phosphorylation in Monocytes and Macrophages via the Proteasome

Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma

(2016) Emma Doran et al.   EUROPEAN RESPIRATORY JOURNAL

SOCS3 is a modulator of human macrophage phagocytosis

(2016) Peter Gordon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gene delivery of suppressors of cytokine signaling (SOCS) inhibits inflammation and atherosclerosis development in mice

(2015) Carlota Recio et al.   BASIC RESEARCH IN CARDIOLOGY

Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons

(2015) Vera Gielen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4

(2015) Faruk Sheikh et al.   Journal of Innate Immunity

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

(2015) Toshiaki Fukushima et al.   Nature Communications

Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins

(2015) Sarah M. McCormick et al.   Frontiers in Immunology

Anti-interleukin 4 and 13 for asthma treatment in the era of endotypes

(2014) Andrew L. Kau et al.   Current Opinion in Allergy and Clinical Immunology

SOCS signaling in autoimmune diseases: Molecular mechanisms and therapeutic implications

(2014) Yan Liang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Efficacy and safety of an anti–IL-13 mAb in patients with severe asthma: A randomized trial

(2014) Erika H. De Boever et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Unique Expression of Suppressor of Cytokine Signaling 3 Is Essential for Classical Macrophage Activation in Rodents In Vitro and In Vivo

(2014) Yu Liu et al.   JOURNAL OF IMMUNOLOGY

Quantitative analysis of the suppressors of cytokine signaling 1 and 3 in peripheral blood leukocytes of patients with multiple sclerosis

(2014) Virginia Sedeño-Monge et al.   JOURNAL OF NEUROIMMUNOLOGY

SOCS Proteins in Macrophage Polarization and Function

(2014) Heather M. Wilson   Frontiers in Immunology

Monoclonal antibodies for the treatment of refractory asthma

(2013) Nathan Hambly et al.   CURRENT OPINION IN PULMONARY MEDICINE

Suppression of cytokine signaling: The SOCS perspective

(2013) Edmond M. Linossi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Therapeutic hope for psoriasis offered by SOCS (suppressor of cytokine signaling) mimetic peptide

(2013) Masato Kubo   EUROPEAN JOURNAL OF IMMUNOLOGY

A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and functionin vitroandin vivo

(2013) Christina E. Arnold et al.   IMMUNOLOGY

An update on biologic-based therapy in asthma

(2013) Garry M Walsh   Immunotherapy

Characterization of Macrophage Phenotypes in Three Murine Models of House-Dust-Mite-Induced Asthma

(2013) Christina Draijer et al.   MEDIATORS OF INFLAMMATION

Expression of SOCSs in human prostate cancer and their association in prognosis

(2013) Jian-guo Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

IL-4/IL-13-Dependent and Independent Expression of miR-124 and Its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and during Allergic Inflammation

(2013) Tatyana Veremeyko et al.   PLoS One

Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation

(2012) Andrew Q Ford et al.   BMC IMMUNOLOGY

Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

(2012) Sebastian Beck Jorgensen et al.   DIABETES

IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

(2012) Ashish Bhattacharjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus

(2012) I S Leikfoss et al.   GENES AND IMMUNITY

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

(2012) Jeffrey J. Babon et al.   IMMUNITY

Expression of SOCS1 and SOCS3 Is Altered in the Nasal Mucosa of Patients with Mild and Moderate/Severe Persistent Allergic Rhinitis

(2012) Tae Hoon Kim et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Phenotypic characterization of lung macrophages in asthmatic patients: Overexpression of CCL17

(2012) Karl J. Staples et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation

(2012) H. Qin et al.   JOURNAL OF IMMUNOLOGY

The alveolar macrophages in asthma: a double-edged sword

(2012) J Balhara et al.   Mucosal Immunology

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

(2012) H. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways

(2011) Taiga Tamiya et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Suppressors of Cytokine Signaling 3 Expression in Eosinophils: Regulation by PGE2and Th2 Cytokines

(2011) Esther López et al.   Clinical & Developmental Immunology

A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis

(2011) K Vandenbroeck et al.   GENES AND IMMUNITY

Regulation of CD4+ T-cell polarization by suppressor of cytokine signalling proteins

(2011) Camille A. Knosp et al.   IMMUNOLOGY

A SOCS-1 Promoter Variant Is Associated with Total Serum IgE Levels

(2011) J. Mostecki et al.   JOURNAL OF IMMUNOLOGY

Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function

(2011) Claire S. Whyte et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity

(2011) Hong-Erh Liang et al.   NATURE IMMUNOLOGY

High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1β and suppressor of cytokine signalling-1 in mouse pancreatic beta cells

(2010) Panagiotis D. Venieratos et al.   CELLULAR SIGNALLING

A new look at the pathogenesis of asthma

(2010) Stephen T. Holgate et al.   CLINICAL SCIENCE

More alternative activation of macrophages in lungs of asthmatic patients

(2010) Barbro N. Melgert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The IFN- -Dependent Suppressor of Cytokine Signaling 1 Promoter Activity Is Positively Regulated by IFN Regulatory Factor-1 and Sp1 but Repressed by Growth Factor Independence-1b and Kruppel-Like Factor-4, and It Is Dysregulated in Psoriatic Keratinocytes

(2010) S. Madonna et al.   JOURNAL OF IMMUNOLOGY

The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis

(2010) Lindsey D. Jager et al.   JOURNAL OF NEUROIMMUNOLOGY

Pulmonary Suppressor of Cytokine Signaling-1 Induced by IL-13 Regulates Allergic Asthma Phenotype

(2009) Satoru Fukuyama et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interactions between Innate Antiviral and Atopic Immunoinflammatory Pathways Precipitate and Sustain Asthma Exacerbations in Children

(2009) L. S. Subrata et al.   JOURNAL OF IMMUNOLOGY

The SOCS Box Encodes a Hierarchy of Affinities for Cullin5: Implications for Ubiquitin Ligase Formation and Cytokine Signalling Suppression

(2009) Jeffrey J. Babon et al.   JOURNAL OF MOLECULAR BIOLOGY

Suppressor of cytokine signalling-3 inhibits tumor necrosis factor-alpha induced apoptosis and signalling in beta cells

(2009) Christine Bruun et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

(2009) Douglas C. Palmer et al.   TRENDS IN IMMUNOLOGY

The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients

(2008) Jeng-Ting Tsao et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins

(2008) Ioannis D. Dimitriou et al.   IMMUNOLOGICAL REVIEWS

Interaction and Functional Interference of Glucocorticoid Receptor and SOCS1

(2008) Michael C. Haffner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cytokine network in asthma and chronic obstructive pulmonary disease

(2008) Peter J. Barnes   JOURNAL OF CLINICAL INVESTIGATION

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

(2008) Edy Y Kim et al.   NATURE MEDICINE

Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages

(2008) N. M. Heller et al.   Science Signaling