Article
Nutrition & Dietetics
Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Chiara Graziadio, Maria Maisto, Francesca Pivari, Andrea Falco, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano
Summary: Individual differences in chronotype are associated with cardiometabolic risk and gut dysbiosis. Morning chronotype is linked to lower BMI, better metabolic profile, higher adherence to the Mediterranean diet, and lower circulating TMAO concentrations. Higher chronotype scores are mainly associated with lower TMAO concentrations.
Article
Nutrition & Dietetics
Jose L. Flores-Guerrero, Maryse C. J. Oste, Paula B. Baraldi, Margery A. Connelly, Erwin Garcia, Gerjan Navis, Stephan J. L. Bakker, Robin P. F. Dullaart
Summary: This study revealed that trimethylamine-N-oxide (TMAO) and its dietary determinants are associated with an increased risk of graft failure in renal transplant recipients (RTRs). A predictive model enriched with TMAO and dietary factors showed a higher Net Benefit compared to a previously validated model.
Review
Nutrition & Dietetics
Edoardo Tacconi, Giuseppe Palma, Davide De Biase, Antonio Luciano, Massimiliano Barbieri, Filomena de Nigris, Francesca Bruzzese
Summary: TMAO is a microbial metabolite that is closely related to gut microbiota and has implications for gastrointestinal cancers, cardiovascular disease, and systemic inflammation. The composition of gut microbiota plays a crucial role in the production of pro-inflammatory TMAO, and the culprits may be certain food sources such as high fat meat, offal, egg yolk, whole dairy products, and fatty fish.
Article
Nutrition & Dietetics
Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Giulia de Alteriis, Maria Maisto, Marianna Donnarumma, Gian Carlo Tenore, Annamaria Colao, Gabriella Fabbrocini, Silvia Savastano
Summary: In this study, circulating TMAO levels were higher and adherence to the Mediterranean diet was lower in HS patients, with HS patients of higher severity showing higher BMI, waist circumference, and energy intake but lower PhA and MD adherence. Circulating TMAO levels were positively correlated with HS severity, and both circulating TMAO levels and PhA were main predictors of HS clinical severity.
Review
Physiology
Katongo H. Mutengo, Sepiso K. Masenga, Aggrey Mweemba, Wilbroad Mutale, Annet Kirabo
Summary: The human gut microbiota and its dependant metabolite, trimethylamine N-oxide, play significant roles in the development of hypertension. This review examines the impact of the gut microbiota and trimethylamine N-oxide on hypertension pathogenesis, providing evidence from both human and animal studies. New insights into potential therapies for managing hypertension by altering the gut microbiota are also discussed.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Nutrition & Dietetics
Mauro Lombardo, Giovanni Aulisa, Daniele Marcon, Gianluca Rizzo, Maria Grazia Tarsisano, Laura Di Renzo, Massimo Federici, Massimiliano Caprio, Antonino De Lorenzo
Summary: There is a strong correlation between TMAO and fish consumption, particularly saltwater fish and shellfish, while the associations of TMAO with eggs, dairy, and meat are less clear. Plant-based foods do not seem to influence TMAO levels significantly, but this area requires further investigation.
Article
Chemistry, Multidisciplinary
Xiangyu Sun, Yiruo Wang, Ruzhen Zhao, Qifeng Wei, Xiulian Ren
Summary: A method to recover proteins from discarded shrimp shells using deep eutectic solvents (DESs) formed by trimethylamine oxide (TMAO) and proteins as hydrogen bond acceptor and donor, respectively, is reported. The optimal conditions for protein extraction were determined as 7% TMAO concentration, 50°C extraction temperature, and 16 hours extraction time. TMAO achieves extraction by forming hydrogen bonds with amino hydrogen, peptide-bonded hydrogen, and carboxyl hydrogen atoms of proteins. This environmentally friendly method has great potential for protein extraction and resource recycling.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Biochemistry & Molecular Biology
Navdeep Kaur, Geneva LaForce, Deepthi P. Mallela, Prasenjit Prasad Saha, Jennifer Buffa, Xinmin S. S. Li, Naseer Sangwan, Kasia Rothenberg, Weifei Zhu
Summary: Stroke is a common cause of cognitive impairment and dementia. The gut microbe-dependent TMAO pathway has been found to impact stroke severity, but the molecular mechanisms of the microbiome in vascular dementia are still not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Ruxandra Florentina Ionescu, Robert Mihai Enache, Sanda Maria Cretoiu, Dragos Cretoiu
Summary: The human microbiota consists of microorganisms found on the skin, mucosal surfaces, and other tissues, with the gut microbiota being the major component. Changes in the gut microbiota can lead to pathophysiological changes that influence the progression of various diseases, including cardiovascular diseases. miRNAs are small non-coding RNAs that play a role in regulating gene expression. The interactions between gut microbiota, miRNAs, and cardiovascular diseases have been explored.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Qiqi Wang, Yue Sun, Tianyu Zhou, Cong Jiang, A. Lan, Wenzhou Xu
Summary: This study found that intestinal inflammation and periodontitis influence each other through a bidirectional relationship. The intestinal microbiome metabolite, TMAO, may contribute to chronic inflammation in the gut by influencing the gut microbial composition and intestinal immunity. The results suggest that TMAO may influence periodontal immunity and promote periodontal inflammation by affecting the intestinal microenvironment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jose L. Flores-Guerrero, Adrian Post, Peter R. van Dijk, Margery A. Connelly, Erwin Garcia, Gerjan Navis, Stephan J. L. Bakker, Robin P. F. Dullaart
Summary: This study revealed that plasma concentrations of TMAO were associated with all-cause mortality in subjects with NAFLD, independently of traditional risk factors. However, such an association was not present in subjects without NAFLD.
LIVER INTERNATIONAL
(2021)
Article
Chemistry, Physical
Bailang Liu, Toshiko Ichiye
Summary: Organic cosolutes can significantly affect protein stability, and their behavior in aqueous solutions provides insights into their molecular effects. Molecular dynamics simulations were used to study the differences between urea, methylureas, and trimethylamine N-oxide (TMAO) in aqueous solutions. The simulations revealed slower diffusion of cosolutes with increasing concentration, as well as with larger size. TMAO showed even slower diffusion due to greater hydration, leading to stronger hydrogen bonding and slower diffusion.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Medicine, General & Internal
Jose L. Flores-Guerrero, Peter R. van Dijk, Margery A. Connelly, Erwin Garcia, Henk J. G. Bilo, Gerjan Navis, Stephan J. L. Bakker, Robin P. F. Dullaart
Summary: Research showed that high plasma TMAO concentrations in patients with T2D are associated with an increased risk of cardiovascular mortality, while BCAA concentrations are not.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: TMAO may be involved in impairing the endothelial-dependent vasodilatory mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Carolina Baraldi A. Restini, Gregory D. Fink, Stephanie W. Watts
Summary: Trimethylamine and Trimethylamine-N-Oxide may directly affect vascular tone, with the former causing greater arterial constriction than the latter. Perivascular adipose tissue and endothelium play regulatory roles in this process.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Courtney A. Deck, Abigail B. Bockus, Brad A. Seibel, Patrick J. Walsh
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2016)
Article
Geochemistry & Geophysics
Steven Carey, Rene Olsen, Katherine L. C. Bell, Robert Ballard, Frederic Dondin, Chris Roman, Clara Smart, Marvin Lilley, John Lupton, Brad Seibel, Winton Cornell, Craig Moyer
GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS
(2016)
Article
Zoology
Brad A. Seibel, Jillian L. Schneider, Stein Kaartvedt, Karen F. Wishner, Kendra L. Daly
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2016)
Article
Biodiversity Conservation
Matthew A. Birk, Christopher Paight, Brad A. Seibel
JOURNAL OF NATURAL HISTORY
(2017)
Correction
Marine & Freshwater Biology
Danna J. Staaf, Susana Camarillo-Coop, Steven H. D. Haddock, Al C. Nyack, John Payne, Cesar A. Salinas-Zavala, Brad A. Seibel, Lloyd Trueblood, Chad Widmer, William F. Gilly
JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM
(2017)
Review
Physiology
Brad A. Seibel
Article
Oceanography
Steven H. D. Haddock, Lynne M. Christianson, Warren R. Francis, Severine Martini, Casey W. Dunn, Philip R. Pugh, Claudia E. Mills, Karen J. Osborn, Brad A. Seibel, C. Anela Choy, Christine E. Schnitzler, George I. Matsumoto, Monique Messie, Darrin T. Schultz, Jacob R. Winnikoff, Meghan L. Powers, Rebeca Gasca, William E. Browne, Sonke Johnsen, Kyra L. Schlining, Susan von Thun, Benjamin E. Erwin, Joseph F. Ryan, Erik V. Thuesen
Article
Biochemistry & Molecular Biology
Hanane Hadj-Moussa, Samantha M. Logan, Brad A. Seibel, Kenneth B. Storey
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2018)
Article
Biochemistry & Molecular Biology
Brad A. Seibel, Bryan E. Luu, Shannon N. Tessier, Trisha Towanda, Kenneth B. Storey
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2018)
Article
Biology
Matthew A. Birk, Erin L. McLean, Brad A. Seibel
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Article
Biology
Matthew A. Birk, Agnieszka K. Dymowska, Brad A. Seibel
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Article
Oceanography
Brenna Meath, Ernst B. Peebles, Brad A. Seibel, Heather Judkins
CONTINENTAL SHELF RESEARCH
(2019)
Article
Multidisciplinary Sciences
K. F. Wishner, B. A. Seibel, C. Roman, C. Deutsch, D. Outram, C. T. Shaw, M. A. Birk, K. A. S. Mislan, T. J. Adams, D. Moore, S. Riley
Article
Oceanography
Israel Ambriz-Arreola, Jaime Gomez-Gutierrez, Maria del Carmen Franco-Gordo, Ricardo J. Palomares-Garcia, Laura Sanchez-Velasco, Carlos J. Robinson, Brad A. Seibel
DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS
(2017)
Article
Biochemistry & Molecular Biology
Sang Hyuck Lee, Mi Ae Kim, Young Chang Sohn
Summary: This study characterized the CCAP signaling system in Pacific abalone and revealed its relationship with the calcium/PKC and cAMP/PKA signal transduction pathways. It provides new insights into the evolutionary origins of the NPS and OT/VP signaling systems in protostomes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Hanna Scheuffele, Erica V. Todd, John A. Donald, Timothy D. Clark
Summary: Global warming is causing an increase in extreme weather events, affecting ecosystems and the behavior of ectotherms. More research is needed to understand the impact of diurnal thermal variability and improve climate change predictions.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jaakko Haverinen, Ahmed Badr, Markus Eskelinen, Matti Vornanen
Summary: The acclimatization of certain ectothermic vertebrates to winter conditions involves reduced energy consumption, achieved through decreased movement activity, depression of cellular functions, or switching to anaerobic energy production. This study on crucian carp showed that winter-acclimatized fish exhibited lower metabolic rates and a shift to anaerobic energy production during anoxia. Winter dormancy in crucian carp is achieved through active reduction of energy consumption, a slowed metabolic rate, and a direct response to oxygen absence.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Maria Cruz Sueiro, Cynthia A. Awruch, Gustavo M. Somoza, Walter S. Svagelj, Maria G. Palacios
Summary: According to life-history theory, there might be different immunological strategies between reproductive and non-reproductive periods due to limited resources. Our study on two sympatric marine fish species, rockfish and sandperch, found that reproductive individuals showed lower immune function, but higher levels of natural antibodies in rockfish females, compared to their non-reproductive counterparts. On the other hand, reproductively active sandperch males showed lower levels of natural antibodies and higher neutrophil to lymphocyte ratio and spleen index compared to non-reproductive males. The study highlights the species-specific patterns of immunity and the potential influence of resource limitation and abiotic factors on immune trade-offs in fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
James B. Cummins, Dane A. Crossley II
Summary: This study focuses on cardiovascular development in altricial bird species, which has been less studied compared to precocial species. The researchers investigated the cholinergic and adrenergic receptor mediated control of arterial blood pressure and heart rate in the neotropic cormorant. The findings suggest that both cholinergic and adrenergic tone play a role in cardiovascular regulation in embryonic birds.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ru Xia, Hong-Kang Liu, Xi-Feng Liu, Xin Deng, Chuan-Jie Qin, Yuan-Fa He, Shi-Mei Lin, Yong-Jun Chen
Summary: This study cloned the genes encoding glucokinase and glucose-6-phosphatase catalytic subunit in largemouth bass, revealing their distribution and transcriptional regulation. The results showed that the functions of G6pc and Gck in LMB were highly conserved in evolution, and the interconversion of glucose and G6P in the liver was well regulated at the transcript level under high starch diet, but a futile cycle was induced after a glucose load.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)