Mapping pathogenesis of arthritis through small animal models

Animal models for arthritis: innovative tools for prevention and treatment

(2011) G. Kollias et al.   ANNALS OF THE RHEUMATIC DISEASES

Matrix metalloproteinase 17 is necessary for cartilage aggrecan degradation in an inflammatory environment

(2011) K. M. Clements et al.   ANNALS OF THE RHEUMATIC DISEASES

T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ

(2011) P.-C. Shen et al.   OSTEOARTHRITIS AND CARTILAGE

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes

(2010) M. Daans et al.   ANNALS OF THE RHEUMATIC DISEASES

Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis

(2010) W. R. Ferrell et al.   ANNALS OF THE RHEUMATIC DISEASES

Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice

(2010) Lin Xu et al.   ARTHRITIS AND RHEUMATISM

Analysis of meniscal degeneration and meniscal gene expression

(2010) Yubo Sun et al.   BMC MUSCULOSKELETAL DISORDERS

Bone marrow lesions in the knee: the clinical conundrum

(2010) Hassan M. BASSIOUNI   International Journal of Rheumatic Diseases

The Aging Stress Response

(2010) Marcia C. Haigis et al.   MOLECULAR CELL

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain

(2010) Kay E. McNamee et al.   PAIN

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

(2010) S. Otsuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis

(2009) Shi-Lu Chia et al.   ARTHRITIS AND RHEUMATISM

Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice

(2009) Yuichiro Matsui et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis

(2009) Natalia Wegner et al.   IMMUNOLOGICAL REVIEWS

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

(2009) Soumya Raychaudhuri et al.   NATURE GENETICS

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Deficiency of tenascin-C delays articular cartilage repair in mice

(2009) N. Okamura et al.   OSTEOARTHRITIS AND CARTILAGE

Commentary: Is It Useful to Subset “Primary” Osteoarthritis? A Critique Based on Evidence Regarding the Etiopathogenesis of Osteoarthritis

(2009) Kenneth D. Brandt et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance

(2009) Balint Farkas et al.   ARTHRITIS RESEARCH & THERAPY

Lessons from animal models of arthritis over the past decade

(2009) Wim Berg   ARTHRITIS RESEARCH & THERAPY

Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system

(2008) Julia J. Inglis et al.   ARTHRITIS AND RHEUMATISM

Protocol for the induction of arthritis in C57BL/6 mice

(2008) Julia J Inglis et al.   Nature Protocols

A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury

(2008) N.M. Eltawil et al.   OSTEOARTHRITIS AND CARTILAGE

Unravelling the relationship between age, nociception and joint destruction in naturally occurring osteoarthritis of Dunkin Hartley guinea pigs

(2008) Jason J. McDougall et al.   PAIN