Impact of Altered Intestinal Microbiota on Chronic Kidney Disease Progression

AGE Content of a Protein Load Is Responsible for Renal Performances: A Pilot Study

(2018) Gabrielle Normand et al.   DIABETES CARE

Albumin downregulates Klotho in tubular cells

(2018) Beatriz Fernandez-Fernandez et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Targeting epigenetic DNA and histone modifications to treat kidney disease

(2018) Miguel Fontecha-Barriuso et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Calciphylaxis

(2018) Sagar U. Nigwekar et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Gut Microbiota and Diet on Uremic Retention Solutes Production in the Context of Chronic Kidney Disease

(2018) Laetitia Koppe et al.   Toxins

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota

(2018) Lesley Hoyles et al.   Microbiome

Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO)

(2018) A. Gessner et al.   Scientific Reports

Short-Chain Fatty Acids Inhibit Oxidative Stress and Inflammation in Mesangial Cells Induced by High Glucose and Lipopolysaccharide

(2017) Wei Huang et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide

(2017) Takeshi Miyake et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Renal Outcomes in Anticoagulated Patients With Atrial Fibrillation

(2017) Xiaoxi Yao et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease

(2017) James A.P. Tomlinson et al.   KIDNEY INTERNATIONAL

The systemic nature of CKD

(2017) Carmine Zoccali et al.   Nature Reviews Nephrology

Resistant starch as a novel dietary strategy to maintain kidney health in diabetes mellitus

(2017) Gar Yee Koh et al.   NUTRITION REVIEWS

Gut microbiome in chronic kidney disease: challenges and opportunities

(2017) Anitha Nallu et al.   Translational Research

Nutrients Turned into Toxins: Microbiota Modulation of Nutrient Properties in Chronic Kidney Disease

(2017) et al.   Nutrients

p-Cresyl Sulfate

(2017) Tessa Gryp et al.   Toxins

Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques

(2017) Emiko Sato et al.   Toxins

Inflammatory Cytokines as Uremic Toxins: “Ni Son Todos Los Que Estan, Ni Estan Todos Los Que Son”

(2017) Esmeralda Castillo-Rodríguez et al.   Toxins

Postprandial gut microbiota-driven choline metabolism links dietary cues to adipose tissue dysfunction

(2017) Rebecca C. Schugar et al.   Adipocyte

Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial

(2017) Rabi Yacoub et al.   PLoS One

Alteration of the gut microbiota in Chinese population with chronic kidney disease

(2017) Shuanghong Jiang et al.   Scientific Reports

TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function

(2017) Eke G. Gruppen et al.   Scientific Reports

Role of the Gut Microbiome in Uremia: A Potential Therapeutic Target

(2016) Ali Ramezani et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Future Avenues to Decrease Uremic Toxin Concentration

(2016) Raymond C. Vanholder et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Vitamin K Deficiency in Chronic Kidney Disease: Evidence Is Building Up

(2016) Maria Fusaro et al.   AMERICAN JOURNAL OF NEPHROLOGY

A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression

(2016) Shuanghong Jiang et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota

(2016) A. Sloan Devlin et al.   Cell Host & Microbe

Metabolism, Protein Binding, and Renal Clearance of Microbiota-Derived p-Cresol in Patients with CKD

(2016) R. Poesen et al.   Clinical Journal of the American Society of Nephrology

Histone lysine crotonylation during acute kidney injury in mice

(2016) Olga Ruiz-Andres et al.   Disease Models & Mechanisms

Targeting inflammation in diabetic kidney disease: early clinical trials

(2016) Maria Vanessa Perez-Gomez et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events

(2016) Richard B. Kim et al.   KIDNEY INTERNATIONAL

Identification and Characterization of Trimethylamine-N-oxide Uptake and Efflux Transporters

(2016) Wendy A. Teft et al.   MOLECULAR PHARMACEUTICS

Clinical management of the uraemic syndrome in chronic kidney disease

(2016) Raymond Vanholder et al.   Lancet Diabetes & Endocrinology

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease

(2016) Catharina Missailidis et al.   PLoS One

The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial

(2016) Ruben Poesen et al.   PLoS One

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

(2015) Michael E. Walsh et al.   AGING CELL

Trimethylamine N-Oxide From Gut Microbiota in Chronic Kidney Disease Patients: Focus on Diet

(2015) Cristiane Moraes et al.   JOURNAL OF RENAL NUTRITION

The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia

(2015) S. Shivanna et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Patiromer in Patients with Kidney Disease and Hyperkalemia Receiving RAAS Inhibitors

(2015) Matthew R. Weir et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sodium Zirconium Cyclosilicate in Hyperkalemia

(2015) David K. Packham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology

(2015) Henricus A.M. Mutsaers et al.   TOXICOLOGY IN VITRO

Albumin-induced apoptosis of tubular cells is modulated by BASP1

(2015) M D Sanchez-Niño et al.   Cell Death & Disease

Meta-Analysis of the Associations of p-Cresyl Sulfate (PCS) and Indoxyl Sulfate (IS) with Cardiovascular Events and All-Cause Mortality in Patients with Chronic Renal Failure

(2015) Cheng-Jui Lin et al.   PLoS One

Expansion of Urease- and Uricase-Containing, Indole- and p-Cresol-Forming and Contraction of Short-Chain Fatty Acid-Producing Intestinal Microbiota in ESRD

(2014) Jakk Wong et al.   AMERICAN JOURNAL OF NEPHROLOGY

Gut Bacterial Translocation May Aggravate Microinflammation in Hemodialysis Patients

(2014) Kehui Shi et al.   DIGESTIVE DISEASES AND SCIENCES

The contributory role of gut microbiota in cardiovascular disease

(2014) W.H. Wilson Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRPs, microbiota, and gut homeostasis: unravelling the connection

(2014) Lia Paola Zambetti et al.   JOURNAL OF PATHOLOGY

The Cardiovascular Effect of the Uremic Solute Indole-3 Acetic Acid

(2014) L. Dou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Uremic Toxicity of Indoxyl Sulfate and p-Cresyl Sulfate: A Systematic Review

(2014) R. Vanholder et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD

(2014) G. Schulman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation

(2014) Nadine Kaesler et al.   KIDNEY INTERNATIONAL

Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure

(2014) Alberto Ortiz et al.   LANCET

Alterations of intestinal barrier and microbiota in chronic kidney disease

(2014) A. Sabatino et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Indoxyl Sulfate Downregulates Expression of Mas Receptor via OAT3/AhR/Stat3 Pathway in Proximal Tubular Cells

(2014) Hwee-Yeong Ng et al.   PLoS One

Podocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand

(2014) Osamu Ichii et al.   PLoS One

Hepatic Sulfotransferase as a Nephropreventing Target by Suppression of the Uremic Toxin Indoxyl Sulfate Accumulation in Ischemic Acute Kidney Injury

(2014) Hideyuki Saito et al.   TOXICOLOGICAL SCIENCES

Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters

(2014) Hideyuki Saito et al.   Drug Design Development and Therapy

The role of menaquinones (vitamin K2) in human health

(2013) Joline W. J. Beulens et al.   BRITISH JOURNAL OF NUTRITION

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

Histone deacetylase inhibitor, sodium butyrate, attenuates gentamicin-induced nephrotoxicity by increasing prohibitin protein expression in rats

(2013) Xuefeng Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction

(2013) E. P. Rhee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase

(2013) Hiroshi Watanabe et al.   KIDNEY INTERNATIONAL

Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway

(2013) Bertrand Gondouin et al.   KIDNEY INTERNATIONAL

The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease

(2013) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

p-Cresyl sulphate has pro-inflammatory and cytotoxic actions on human proximal tubular epithelial cells

(2013) Jonay Poveda et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Indoxyl Sulfate Down-Regulates SLCO4C1 Transporter through Up-Regulation of GATA3

(2013) Yasutoshi Akiyama et al.   PLoS One

Uremic Plasma Impairs Barrier Function and Depletes the Tight Junction Protein Constituents of Intestinal Epithelium

(2012) Nosratola D. Vaziri et al.   AMERICAN JOURNAL OF NEPHROLOGY

Phylloquinone and Vitamin D Status: Associations with Incident Chronic Kidney Disease in the Framingham Offspring Cohort

(2012) Conall M. O’Seaghdha et al.   AMERICAN JOURNAL OF NEPHROLOGY

Role of Urea in Intestinal Barrier Dysfunction and Disruption of Epithelial Tight Junction in Chronic Kidney Disease

(2012) Nosratola D. Vaziri et al.   AMERICAN JOURNAL OF NEPHROLOGY

Uremic Serum and Solutes Increase Post–Vascular Interventional Thrombotic Risk Through Altered Stability of Smooth Muscle Cell Tissue Factor

(2012) Vipul C. Chitalia et al.   CIRCULATION

Normal and Pathologic Concentrations of Uremic Toxins

(2012) F. Duranton et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cilastatin protects against cisplatin-induced nephrotoxicity without compromising its anticancer efficiency in rats

(2012) Blanca Humanes et al.   KIDNEY INTERNATIONAL

Gut bacterial translocation is associated with microinflammation in end-stage renal disease patients

(2012) FEIQIAN WANG et al.   NEPHROLOGY

Sodium butyrate decreases the activation of NF- B reducing inflammation and oxidative damage in the kidney of rats subjected to contrast-induced nephropathy

(2012) R. A. Machado et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells

(2012) C.-Y. Sun et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

(2012) Chiao-Yin Sun et al.   PLoS One

Indoxyl Sulfate Induces Epithelial-to-Mesenchymal Transition in Rat Kidneys and Human Proximal Tubular Cells

(2011) Dilinaer Bolati et al.   AMERICAN JOURNAL OF NEPHROLOGY

Alleviation of cisplatin-induced acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats

(2011) Masahiro Kusumoto et al.   Clinical and Experimental Nephrology

AKI Associated with Macroscopic Glomerular Hematuria: Clinical and Pathophysiologic Consequences

(2011) J. A. Moreno et al.   Clinical Journal of the American Society of Nephrology

Transcriptional Regulation of Organic Anion Transporting Polypeptide SLCO4C1 as a New Therapeutic Modality to Prevent Chronic Kidney Disease

(2011) Takehiro Suzuki et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Examining Associations of Circulating Endotoxin With Nutritional Status, Inflammation, and Mortality in Hemodialysis Patients

(2011) Usama Feroze et al.   JOURNAL OF RENAL NUTRITION

The Inflammatory Cytokines TWEAK and TNF  Reduce Renal Klotho Expression through NF B

(2011) J. A. Moreno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Warfarin-Related Nephropathy Modeled by Nephron Reduction and Excessive Anticoagulation

(2011) K. Ware et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Novel method for simultaneous determination of p-cresylsulphate and p-cresylglucuronide: clinical data and pathophysiological implications

(2011) N. Meert et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Full loss of residual renal function causes higher mortality in dialysis patients; findings from a marginal structural model

(2011) W. M. van der Wal et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

(2011) V. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Endotoxemia: A Novel Factor in Systemic Inflammation and Cardiovascular Disease in Chronic Kidney Disease

(2010) C. W. McIntyre et al.   Clinical Journal of the American Society of Nephrology

Vitamins K and D Status in Stages 3-5 Chronic Kidney Disease

(2010) R. M. Holden et al.   Clinical Journal of the American Society of Nephrology

p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease

(2010) I.-W. Wu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Acute Kidney Injury During Warfarin Therapy Associated With Obstructive Tubular Red Blood Cell Casts: A Report of 9 Cases

(2009) Sergey V. Brodsky et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

SLCO4C1 Transporter Eliminates Uremic Toxins and Attenuates Hypertension and Renal Inflammation

(2009) T. Toyohara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Endotoxemia is Related to Systemic Inflammation and Atherosclerosis in Peritoneal Dialysis Patients

(2008) C.-C. Szeto et al.   Clinical Journal of the American Society of Nephrology

Benefits of preserving residual renal function in peritoneal dialysis

(2008) B. Marrón et al.   KIDNEY INTERNATIONAL